(Q37310211)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18955977%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

review article

1 reference

title

Nucleoside analogs: molecular mechanisms signaling cell death (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18955977%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18955977%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

author name string

B Ewald

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18955977%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

W Plunkett

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18955977%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

language of work or name

English

0 references

publication date

1 October 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18955977%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18955977%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

volume

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18955977%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

page(s)

6522-6537

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18955977%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

issue

50

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18955977%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/onc.2008.316

25 December 2019

exact match

0 references

cites work

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Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells

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Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis

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Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia

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Chk1 in the DNA damage response: conserved roles from yeasts to mammals

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Inhibition of DNA methylation and reactivation of silenced genes by zebularine

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Human claspin is required for replication checkpoint control

31 March 2020

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A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA.

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S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

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ATR and ATRIP: partners in checkpoint signaling

31 March 2020

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Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

31 March 2020

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Interim comparison of a continuous infusion versus a short daily infusion of cytarabine given in combination with cladribine for pediatric acute myeloid leukemia

31 March 2020

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

31 March 2020

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

31 March 2020

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Molecular mechanism of nucleotide excision repair.

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ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation

31 March 2020

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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

31 March 2020

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Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.

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Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia

31 March 2020

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H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation

31 March 2020

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ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance

31 March 2020

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Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997.

31 March 2020

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31 March 2020

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Increased DNA synthesis and repair-enzyme expression in lymphocytes from patients with chronic lymphocytic leukemia resistant to nitrogen mustards.

31 March 2020

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Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway

31 March 2020

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Extended follow-up of patients with hairy cell leukemia after treatment with cladribine

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Comparative study of a novel nucleoside analogue (Troxatyl, troxacitabine, BCH-4556) and AraC against leukemic human tumor xenografts expressing high or low cytidine deaminase activity

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DNA repair pathways as targets for cancer therapy

31 March 2020

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

31 March 2020

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Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study

31 March 2020

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31 March 2020

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

31 March 2020

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Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation

31 March 2020

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p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.

31 March 2020

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Nucleoside analogues in the treatment of haematological malignancies

31 March 2020

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The epigenomics of cancer

31 March 2020

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Relationships between chromatin organization and DNA methylation in determining gene expression

31 March 2020

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Inhibition of the 3' --> 5' exonuclease of human DNA polymerase epsilon by fludarabine-terminated DNA

31 March 2020

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Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

31 March 2020

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Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes

31 March 2020

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Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.

31 March 2020

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Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.

31 March 2020

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Involvement of novel autophosphorylation sites in ATM activation

31 March 2020

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Phosphorylation of pyrimidine deoxynucleoside analog diphosphates: selective phosphorylation of L-nucleoside analog diphosphates by 3-phosphoglycerate kinase

31 March 2020

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Novel role of 3-phosphoglycerate kinase, a glycolytic enzyme, in the activation of L-nucleoside analogs, a new class of anticancer and antiviral agents

31 March 2020

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L- and D-enantiomers of 2',3'-dideoxycytidine 5'-triphosphate analogs as substrates for human DNA polymerases. Implications for the mechanism of toxicity

31 March 2020

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TopBP1 activates the ATR-ATRIP complex

31 March 2020

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DNA damage-induced activation of ATM and ATM-dependent signaling pathways

31 March 2020

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The cyclin-dependent kinase inhibitor UCN-01 plus cisplatin in advanced solid tumors: a California cancer consortium phase I pharmacokinetic and molecular correlative trial

31 March 2020

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The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

31 March 2020

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Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c

31 March 2020

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Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation

31 March 2020

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Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine

31 March 2020

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Characterization of decomposition products and preclinical and low dose clinical pharmacokinetics of decitabine (5-aza-2'-deoxycytidine) by a new liquid chromatography/tandem mass spectrometry quantification method

31 March 2020

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The DNA replication checkpoint response stabilizes stalled replication forks

31 March 2020

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Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

31 March 2020

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CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis

31 March 2020

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Nucleosides and nucleotides. 100. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosyl-cytosine (CNDAC): design of a potential mechanism-based DNA-strand-breaking antineoplastic nucleoside

31 March 2020

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

31 March 2020

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Positional cloning of the gene for Nijmegen breakage syndrome

31 March 2020

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Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo

31 March 2020

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p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells

31 March 2020

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Allelic silencing at the tumor-suppressor locus 13q14.3 suggests an epigenetic tumor-suppressor mechanism

31 March 2020

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DNA damage-dependent nuclear dynamics of the Mre11 complex

31 March 2020

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Synthesis and biological activity of 2'-fluoro-2-halo derivatives of 9-.beta.-D-arabinofuranosyladenine

31 March 2020

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Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

31 March 2020

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The synergistic effect of 5-aza-2'-deoxycytidine and 5-fluorouracil on drug-resistant tumors

31 March 2020

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Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal

31 March 2020

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

31 March 2020

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Hypermethylation of death‐associated protein (DAP) kinase CpG island is frequent not only in B‐cell but also in T‐ and natural killer (NK)/T‐cell malignancies

31 March 2020

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

31 March 2020

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Review: recent clinical trials in epigenetic therapy

31 March 2020

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The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.

31 March 2020

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DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.

31 March 2020

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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

31 March 2020

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The ATR pathway: fine-tuning the fork

31 March 2020

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Modulation of cell cycle progression in human tumors: a pharmacokinetic and tumor molecular pharmacodynamic study of cisplatin plus the Chk1 inhibitor UCN-01 (NSC 638850)

31 March 2020

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Four-dimensional control of the cell cycle

31 March 2020

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Reduction of p53 gene expression in human primary hepatocellular carcinoma is associated with promoter region methylation without coding region mutation

31 March 2020

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CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine

31 March 2020

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Histone methylation versus histone acetylation: new insights into epigenetic regulation

31 March 2020

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The apoptosome: signalling platform of cell death

31 March 2020

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Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil.

31 March 2020

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Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks

31 March 2020

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DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci.

31 March 2020

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Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

31 March 2020

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Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.316

Inhibition of cyclin-dependent kinase 2 by the Chk1-Cdc25A pathway during the S-phase checkpoint activated by fludarabine: dysregulation by 7-hydroxystaurosporine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.316

Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.316

31 March 2020

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The ATM-mediated DNA-damage response: taking shape.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.316

The inhibition of ultraviolet radiation-induced DNA repair in human diploid fibroblasts by arabinofuranosyl nucleosides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.316

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.316

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.316

DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity

31 March 2020

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Comprehensive analysis of CpG islands in human chromosomes 21 and 22

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.316

A role for ATR in the DNA damage-induced phosphorylation of p53

31 March 2020

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miRNAs and their potential for use against cancer and other diseases

31 March 2020

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ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

31 March 2020

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Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Targeting checkpoint kinase 1 in cancer therapeutics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter's syndrome or fludarabine-refractory chronic lymphocytic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

The MRN complex: coordinating and mediating the response to broken chromosomes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5'-diphosphate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Repair of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: a study of the Princess Margaret Hospital Phase II consortium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Turning the replication checkpoint on and off.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Quantification of 5-azacytidine in plasma by electrospray tandem mass spectrometry coupled with high-performance liquid chromatography.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.316

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ONC.2008.316

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18955977%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference