(Q37327316)

19 August 2017

Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding (English)

1 reference

19 August 2017

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Emma Davé

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Ralph Adams

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Oliver Zaccheo

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Bruce Carrington

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Joanne E Compson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Sarah Dugdale

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Michael Airey

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Sarah Malcolm

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Hanna Hailu

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Gavin Wild

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Alison Turner

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

James Heads

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Andrew Ventom

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Diane Marshall

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Mark Jairaj

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Tim Kopotsha

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Louis Christodoulou

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Miren Zamacona

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Alastair D Lawson

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Sam Heywood

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

David P Humphreys

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

publication date

17 August 2016

1 reference

19 August 2017

Monoclonal Antibodies

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

1319-1335

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 3.0 Unported

12 June 2020

copyright license

start time

17 August 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

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6 September 2017

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Albumin as a versatile platform for drug half-life extension

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A CHO cell line engineered to express XBP1 and ERO1-Lα has increased levels of transient protein expression

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6 September 2017

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Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3.

6 September 2017

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Impact of albumin on drug delivery--new applications on the horizon.

6 September 2017

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Strategies for extended serum half-life of protein therapeutics

6 September 2017

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Extending half-life by indirect targeting of the neonatal Fc receptor (FcRn) using a minimal albumin binding domain

6 September 2017

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Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?

6 September 2017

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Tuning the serum persistence of human serum albumin domain III:diabody fusion proteins

6 September 2017

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Anti-CD40L immune complexes potently activate platelets in vitro and cause thrombosis in FCGR2A transgenic mice

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Strategies to extend plasma half-lives of recombinant antibodies

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Practical aspects of the ligand-binding and enzymatic properties of human serum albumin.

6 September 2017

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PEGylated antibodies and antibody fragments for improved therapy: a review

6 September 2017

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Stability engineering of antibody single-chain Fv fragments

6 September 2017

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The three recombinant domains of human serum albumin. Structural characterization and ligand binding properties

6 September 2017

1 reference

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Pharmacokinetics and biodistribution of genetically-engineered antibodies

6 September 2017

1 reference

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A recombinant immunotoxin containing a disulfide-stabilized Fv fragment

6 September 2017

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Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors

6 September 2017

1 reference

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Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life

6 September 2017

1 reference

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Fusions of elastin-like polypeptides to pharmaceutical proteins.

14 September 2017

1 reference

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The effects of affinity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein

14 September 2017

1 reference

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Plasma and tissue protein binding of drugs in pharmacokinetics

14 September 2017

1 reference

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Plasma half-life extension of small recombinant antibodies by fusion to immunoglobulin-binding domains

28 September 2017

1 reference

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A fully automated primary screening system for the discovery of therapeutic antibodies directly from B cells

28 September 2017

1 reference

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Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn).

26 June 2018

1 reference

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The binding of sodium dodecyl sulphate to various proteins

26 June 2018

1 reference

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Mobility of sodium dodecyl sulphate - protein complexes

26 June 2018

1 reference

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Nonclinical safety of mavrilimumab, an anti-GMCSF receptor alpha monoclonal antibody, in cynomolgus monkeys: relevance for human safety

26 June 2018

1 reference

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Extending the serum half-life of G-CSF via fusion with the domain III of human serum albumin

2 September 2018

1 reference

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Single-chain variable fragment albumin fusions bind the neonatal Fc receptor (FcRn) in a species-dependent manner: implications for in vivo half-life evaluation of albumin fusion therapeutics

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058625

Immunogenicity assays for antibody-drug conjugates: case study with ado-trastuzumab emtansine.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058625

A multiple-dose toxicity study of tanezumab in cynomolgus monkeys.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058625

The production, characterisation and enhanced pharmacokinetics of scFv-albumin fusions expressed in Saccharomyces cerevisiae

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058625

Relevant shaking stress conditions for antibody preformulation development

2 September 2018

1 reference

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New strategy for the extension of the serum half-life of antibody fragments

2 September 2018

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Immunogenicity of biologically-derived therapeutics: assessment and interpretation of nonclinical safety studies

2 September 2018

1 reference

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Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058625

A broad range of Fab stabilities within a host of therapeutic IgGs.

2 September 2018

1 reference

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Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058625

The pharmacokinetics of an albumin-binding Fab (AB.Fab) can be modulated as a function of affinity for albumin.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058625

Albumin binding to FcRn: distinct from the FcRn-IgG interaction.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058625

Albumin binding as a general strategy for improving the pharmacokinetics of proteins

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058625

Prolonged in vivo residence times of antibody fragments associated with albumin

2 September 2018

1 reference

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An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability.

2 September 2018

1 reference

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Therapeutic antibody fragments with prolonged in vivo half-lives

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058625

Production of Monoclonal Antibodies

20 October 2018

1 reference

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Removal of the conserved disulfide bridges from the scfv fragment of an antibody: effects on folding kinetics and aggregation

21 January 2018

1 reference

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Further characterization of specific drug binding sites on human serum albumin

21 January 2018

1 reference

12 December 2020

Thermodynamic features of the thermal unfolding of human serum albumin

1 reference

12 December 2020

Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin

1 reference

12 December 2020

GSK2374697, a novel albumin-binding domain antibody (AlbudAb), extends systemic exposure of exendin-4: first study in humans--PK/PD and safety

1 reference

12 December 2020

Thermodynamic aspects of the thermal stability of human serum albumin

1 reference

12 December 2020

The characterization of two specific drug binding sites on human serum albumin

1 reference

12 December 2020

The role of CD40 in CD40L- and antibody-mediated platelet activation

1 reference

12 December 2020

Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand

1 reference

12 December 2020

Interhelical hydrogen bonds in the CFTR membrane domain

1 reference

12 December 2020

10.1080/19420862.2016.1210747

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532598%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference