(Q37329175)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19018727%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

review article

1 reference

title

CYP2A6 polymorphisms and risk for tobacco-related cancers (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19018727%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19018727%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Ana Rossini

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19018727%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Tatiana de Almeida Simão

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19018727%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Luis Felipe Ribeiro Pinto

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19018727%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

publication date

1 November 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19018727%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19018727%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19018727%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19018727%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

1737-1752

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19018727%20AND%20SRC:MED&resulttype=core&format=json

Cancer burden in the year 2000. The global picture

17 January 2020

cites work

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Determination of 14 polycyclic aromatic hydrocarbons in mainstream smoke from U.S. brand and non-U.S. brand cigarettes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Levels of toxins in oral tobacco products in the UK.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Tobacco carcinogens, their biomarkers and tobacco-induced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Determination of carcinogenic tobacco-specific nitrosamines in mainstream smoke from U.S.-brand and non-U.S.-brand cigarettes from 14 countries

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Expression of CYP2A genes in human liver and extrahepatic tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Nicotine 5'-oxidation and methyl oxidation by P450 2A enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Metabolism of nicotine and cotinine by human cytochrome P450 2A13.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Regulation of the cytochrome P450 2A genes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Human CYP2A6 is induced by estrogen via estrogen receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Kinetics and enzyme involvement in the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in microsomes of rat lung and nasal mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Identification of novel CYP2A6*1B variants: the CYP2A6*1B allele is associated with faster in vivo nicotine metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

3'-UTR polymorphism in the human CYP2A6 gene affects mRNA stability and enzyme expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

CYP2A6*6, a novel polymorphism in cytochrome p450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

CYP2A6 polymorphisms in Malays, Chinese and Indians.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Comparison of cytochrome P450 2A6 polymorphism frequencies in Caucasians and African-Americans using a new one-step PCR-RFLP genotyping method

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

CYP2A6 genetic polymorphisms and correlation with smoking status in Brazilians.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

CYP2A6 and CYP2E1 polymorphisms in a Brazilian population living in Rio de Janeiro

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

High prevalence of cytochrome P450 2A6*1A alleles in a black African population of Ghana

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Genetic polymorphism of CYP2A6 in the German population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Homologous unequal cross-over within the human CYP2A gene cluster as a mechanism for the deletion of the entire CYP2A6 gene associated with the poor metabolizer phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Structural characterization of a new variant of the CYP2A6 gene (CYP2A6*1B) apparently diagnosed as heterozygotes of CYP2A6*1A and CYP2A6*4C.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Identification of deletion-junction site of CYP2A6*4B allele lacking entire coding region of CYP2A6 in Japanese

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Inter-gene correlation on oligonucleotide arrays: how much does normalization matter?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Genetic polymorphisms of cytochrome P450 in patients with hepatitis C virus-associated hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Cytochrome P450 2A6 polymorphism in nasopharyngeal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Characterization of novel CYP2A6 polymorphic alleles (CYP2A6*18 and CYP2A6*19) that affect enzymatic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

A novel polymorphism of human CYP2A6 gene CYP2A6*17 has an amino acid substitution (V365M) that decreases enzymatic activity in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

A nicotine C-oxidase gene (CYP2A6) polymorphism important for promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Polymorphic NF-Y dependent regulation of human nicotine C-oxidase (CYP2A6).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: impairment of its promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Effects of polymorphism in promoter region of human CYP2A6 gene (CYP2A6*9) on expression level of messenger ribonucleic acid and enzymatic activity in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Three haplotypes associated with CYP2A6 phenotypes in Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

The significance of the homozygous CYP2A6 deletion on nicotine metabolism: a new genotyping method of CYP2A6 using a single PCR-RFLP

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Nicotine metabolism defect reduces smoking.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

The genetics of smoking persistence in men and women: a multicultural study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Molecular and cellular aspects of nicotine abuse

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

CYP2A6 genetic variation and potential consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Genetic variability in CYP2A6 and the pharmacokinetics of nicotine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Nicotine metabolism and CYP2A6 allele frequencies in Koreans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Metabolism and disposition kinetics of nicotine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Decreasing smoking behaviour and risk through CYP2A6 inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Effects of cytochrome P450 (CYP) 2A6 gene deletion and CYP2E1 genotypes on gastric adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Genetic polymorphism of CYP2A6 in relation to cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737

In vivo Evaluation of Coumarin and Nicotine as Probe Drugs to Predict the Metabolic Capacity of CYP2A6 Due to Genetic Polymorphism in Thais

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.11.1737