(Q37346216)

19 August 2017

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title

Pharmacoepigenomics in colorectal cancer: a step forward in predicting prognosis and treatment response (English)

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19 August 2017

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7

Manon van Engeland

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19 August 2017

Kim M Smits

1

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19 August 2017

Arjen H G Cleven

2

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19 August 2017

Matty P Weijenberg

3

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19 August 2017

Laura A E Hughes

4

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19 August 2017

James G Herman

5

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19 August 2017

Adriaan P de Bruïne

6

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19 August 2017

1 December 2008

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19 August 2017

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19 August 2017

9

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19 August 2017

12

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19 August 2017

1903-1916

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Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature

19 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Tumour markers of prognosis in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Estimates of the cancer incidence and mortality in Europe in 2006.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Prospective evaluation of screening colonoscopy: who is being screened?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Enhanced retrieval of DNA from human fecal samples results in improved performance of colorectal cancer screening test

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Hypermethylation of SFRP2 as a potential marker for stool-based detection of colorectal cancer and precancerous lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Hypermethylated SFRP2 gene in fecal DNA is a high potential biomarker for colorectal cancer noninvasive screening

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

The staging of colorectal cancer: 2004 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Genetic alterations during colorectal-tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

A genetic model for colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

APC mutations occur early during colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Identification and characterization of the familial adenomatous polyposis coli gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Molecular genetics of colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

The APC gene in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Genetic prognostic markers in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Identification of a chromosome 18q gene that is altered in colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Microsatellite instability in cancer of the proximal colon

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Methylation profile of the MLH1 promoter region and their relationship to colorectal carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

The colorectal adenoma-carcinoma sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

The consensus coding sequences of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

The genomic landscapes of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Cancer genes and the pathways they control

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Lessons from hereditary colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Systematic review of genetic influences on the prognosis of colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Genetic alterations in locally advanced stage II/III colon cancer: a search for prognostic markers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Chromosome 18q allelic loss and prognosis in stage II and III colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Transforming growth factor beta 1 expression in human colorectal tumours: an independent prognostic marker in a subgroup of poor prognosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Potential predictive markers of response to EGFR-targeted therapies in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Hypermethylation of tumor suppressor genes in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Gene silencing in cancer in association with promoter hypermethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

The epigenomics of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Comparing the DNA hypermethylome with gene mutations in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

CpG island methylator phenotype in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Molecular classification and correlates in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Systematic review of microsatellite instability and colorectal cancer prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Low microsatellite instability is associated with poor prognosis in stage C colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Management of advanced colorectal cancer: state of the art.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Guidelines 2000 for colon and rectal cancer surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

First-line chemotherapy in metastatic colorectal cancer: new approaches and therapeutic algorithms. Always hit hard first?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Cetuximab plus FOLFOX-4 for fully resected stage III colon carcinoma: scientific background and the ongoing PETACC-8 trial

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Thymidylate synthase pharmacogenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Pharmacogenomics in colorectal cancer: the first step for individualized-therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Pharmacogenetics in colorectal cancer: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

The power and the promise of DNA methylation markers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Targeting aberrant chromatin structure in colorectal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Histone deacetylase inhibitors in programmed cell death and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

HDAC2 deficiency and histone acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Profiling markers of prognosis in colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Epigenetic inactivation of CHFR in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Aberrant hypermethylation of the promoter region of the CHFR gene is rare in primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Chromosomal instability, colorectal cancer and taxane resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

High sensitivity mapping of methylated cytosines

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

21 January 2018

The mammalian epigenome

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Epigenomics: mapping the methylome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

The methylome: approaches for global DNA methylation profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

MIRA-assisted microarray analysis, a new technology for the determination of DNA methylation patterns, identifies frequent methylation of homeodomain-containing genes in lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Predicting aberrant CpG island methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

High-resolution profiling of histone methylations in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Reporting recommendations for tumor marker prognostic studies (REMARK).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Is molecular profiling ready for use in clinical decision making?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Why most published research findings are false

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Molecular markers for diagnosis and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Moving AHEAD with an international human epigenome project.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite Instability

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

Tumor Thymidylate Synthase 1494del6 Genotype As a Prognostic Factor in Colorectal Cancer Patients Receiving Fluorouracil-Based Adjuvant Treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.12.1903

10.2217/14622416.9.12.1903

21 January 2018

Identifiers

DOI

1 reference

19 August 2017

1 reference