(Q37349652)

19 August 2017

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title

The biology of Hodgkin's lymphoma (English)

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19 August 2017

1

Ralf Küppers

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language of work or name

English

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publication date

11 December 2008

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19 August 2017

published in

Nature Reviews Cancer

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19 August 2017

volume

9

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19 August 2017

issue

1

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19 August 2017

page(s)

15-27

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On some Morbid Appearances of the Absorbent Glands and Spleen

19 August 2017

cites work

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Part II: Hodgkin's lymphoma--diagnosis and treatment

31 March 2020

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Clonal selection and learning in the antibody system

31 March 2020

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Germinal-center organization and cellular dynamics

31 March 2020

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Differential expression of activation-induced cytidine deaminase (AID) in nodular lymphocyte-predominant and classical Hodgkin lymphoma.

31 March 2020

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Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells

31 March 2020

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Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development

31 March 2020

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Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells

31 March 2020

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Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis

31 March 2020

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Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

31 March 2020

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THE ORIGIN OF HODGKIN AND REED/STERNBERG CELLS IN HODGKIN'S DISEASE

31 March 2020

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Somatic hypermutation in normal and transformed human B cells

31 March 2020

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Class switch recombination was specifically targeted to immunoglobulin (Ig)G4 or IgA in Hodgkin's disease-derived cell lines

31 March 2020

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Chromosomal Breakpoints Affecting Immunoglobulin Loci Are Recurrent in Hodgkin and Reed-Sternberg Cells of Classical Hodgkin Lymphoma

31 March 2020

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Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma

31 March 2020

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Classical Hodgkin's disease and follicular lymphoma originating from the same germinal center B cell

31 March 2020

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Rare occurrence of classical Hodgkin's disease as a T cell lymphoma

31 March 2020

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Rare expression of T-cell markers in classical Hodgkin's lymphoma

31 March 2020

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T-cell variant of classical Hodgkin's lymphoma with nodal and cutaneous manifestations demonstrated by single-cell polymerase chain reaction

31 March 2020

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Peripheral T-cell lymphomas expressing CD30 and CD15.

31 March 2020

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Mechanisms of B-cell lymphoma pathogenesis

31 March 2020

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Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

31 March 2020

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Expression of B7-2 (CD86) molecules by Reed-Sternberg cells of Hodgkin's disease

31 March 2020

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Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

31 March 2020

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Immunophenotypes of Reed-Sternberg cells and their variants: a study of 68 cases of Hodgkin's disease

31 March 2020

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Recent results on the biology of Hodgkin and Reed-Sternberg cells. I. Biopsy material

31 March 2020

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High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltratein Hodgkin's lymphoma

31 March 2020

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Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription

31 March 2020

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The transcription factor PU.1, necessary for B-cell development is expressed in lymphocyte predominance, but not classical Hodgkin's disease

31 March 2020

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Patterned CpG methylation of silenced B cell gene promoters in classical Hodgkin lymphoma-derived and primary effusion lymphoma cell lines.

31 March 2020

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Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma

31 March 2020

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Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma.

31 March 2020

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Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5.

31 March 2020

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Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling

31 March 2020

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Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma

31 March 2020

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Transcriptional profiling identifies Id2 function in dendritic cell development

31 March 2020

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Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2.

31 March 2020

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Pax5: the guardian of B cell identity and function

31 March 2020

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Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

31 March 2020

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Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma.

31 March 2020

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IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis

31 March 2020

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The early transcription factor GATA-2 is expressed in classical Hodgkin's lymphoma

31 March 2020

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Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression

31 March 2020

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Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma-derived cell lines

31 March 2020

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Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease

31 March 2020

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Abnormal PcG protein expression in Hodgkin's lymphoma. Relation with E2F6 and NFkappaB transcription factors.

31 March 2020

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Multilineage gene expression precedes commitment in the hemopoietic system

31 March 2020

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Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment.

31 March 2020

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Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells

31 March 2020

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Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma

31 March 2020

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TP53 gene mutations in Hodgkin lymphoma are infrequent and not associated with absence of Epstein-Barr virus

31 March 2020

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XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells

31 March 2020

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Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death

31 March 2020

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c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis

31 March 2020

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Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma

31 March 2020

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Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation

31 March 2020

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Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6

31 March 2020

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Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma

31 March 2020

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Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2.

31 March 2020

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Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma.

31 March 2020

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Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma

31 March 2020

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Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas

31 March 2020

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Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

31 March 2020

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Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma

31 March 2020

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Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells

31 March 2020

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Specific function of STAT3, SOCS1, and SOCS3 in the regulation of proliferation and survival of classical Hodgkin lymphoma cells

31 March 2020

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STAT3 is constitutively activated in Hodgkin cell lines

31 March 2020

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Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

31 March 2020

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Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells

31 March 2020

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Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity

31 March 2020

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Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha

31 March 2020

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Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL

31 March 2020

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Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines.

31 March 2020

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Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells

31 March 2020

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Mast cells express functional CD30 ligand and are the predominant CD30L-positive cells in Hodgkin's disease.

31 March 2020

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CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells

31 March 2020

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Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells

31 March 2020

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Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3

31 March 2020

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Paracrine promotion of tumor development by the TNF ligand APRIL in Hodgkin's Disease

31 March 2020

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Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells

31 March 2020

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TRAF1 expression and c-Rel activation are useful adjuncts in distinguishing classical Hodgkin lymphoma from a subset of morphologically or immunophenotypically similar lymphomas

31 March 2020

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Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR.

31 March 2020

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Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.

31 March 2020

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Autocrine- and paracrine-activated receptor tyrosine kinases in classic Hodgkin lymphoma

31 March 2020

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MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival

31 March 2020

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The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma

31 March 2020

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AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells

31 March 2020

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High expression of several tyrosine kinases and activation of the PI3K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma

31 March 2020

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Epstein-Barr virus is associated with all histological subtypes of Hodgkin lymphoma in Vietnamese children with special emphasis on the entity of lymphocyte predominance subtype

31 March 2020

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Pathogenetic and histogenetic features of HIV-associated Hodgkin's disease.

31 March 2020

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Spectrum of Epstein-Barr virus-associated diseases

31 March 2020

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Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells

31 March 2020

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Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells.

31 March 2020

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Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice

31 March 2020

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Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor

31 March 2020

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Epstein-Barr virus and oncogenesis: from latent genes to tumours

31 March 2020

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Molecular mimicry of the antigen receptor signalling motif by transmembrane proteins of the Epstein-Barr virus and the bovine leukaemia virus.

31 March 2020

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Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals

31 March 2020

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Mechanism of antigen-driven selection in germinal centres

31 March 2020

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Epstein-Barr Virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphoma

31 March 2020

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The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype.

31 March 2020

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The aberrant coexpression of several receptor tyrosine kinases is largely restricted to EBV-negative cases of classical Hodgkin's lymphoma

31 March 2020

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Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas

31 March 2020

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Rescue of "crippled" germinal center B cells from apoptosis by Epstein-Barr virus

31 March 2020

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Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes

31 March 2020

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Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival

31 March 2020

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Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma

31 March 2020

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Cancer stem cells: at the headwaters of tumor development

31 March 2020

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Formation of multinucleated cells in a Hodgkin's-disease-derived cell line

31 March 2020

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L-428 Reed-Sternberg cells and mononuclear Hodgkin's cells arise from a single cloned mononuclear cell

31 March 2020

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Morphologically normal, CD30-negative B-lymphocytes with chromosome aberrations in classical Hodgkin's disease: the progenitor cell of the malignant clone?

31 March 2020

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Chromosome abnormalities in peripheral blood lymphocytes from untreated Hodgkin's patients. A possible evidence for chromosome instability

31 March 2020

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Baseline and treatment-induced chromosomal abnormalities in peripheral blood lymphocytes of Hodgkin's lymphoma patients

31 March 2020

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The role of cytokines in classical Hodgkin lymphoma

31 March 2020

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Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions.

31 March 2020

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Expression of CCL5/RANTES by Hodgkin and Reed-Sternberg cells and its possible role in the recruitment of mast cells into lymphomatous tissue

31 March 2020

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Disseminated growth of Hodgkin's-derived cell lines L540 and L540cy in immune-deficient SCID mice

31 March 2020

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Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS

31 March 2020

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Expression of functional interleukin-3 receptors on Hodgkin and Reed-Sternberg cells

31 March 2020

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Interactions between tissue fibroblasts in lymph nodes and Hodgkin/Reed-Sternberg cells.

31 March 2020

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Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients.

31 March 2020

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Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma

31 March 2020

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Hodgkin's reed-sternberg cell line (KM-H2) promotes a bidirectional differentiation of CD4+CD25+Foxp3+ T cells and CD4+ cytotoxic T lymphocytes from CD4+ naive T cells

31 March 2020

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Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells

31 March 2020

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The ratio of FOXP3+ regulatory T cells to granzyme B+ cytotoxic T/NK cells predicts prognosis in classical Hodgkin lymphoma and is independent of bcl-2 and MAL expression

31 March 2020

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Humoral immunity, inflammation and cancer

31 March 2020

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Galectin-1 mediated suppression of Epstein-Barr virus specific T-cell immunity in classic Hodgkin lymphoma.

31 March 2020

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Transforming growth factor beta 1 messenger RNA in Reed-Sternberg cells in nodular sclerosing Hodgkin's disease

31 March 2020

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Prostaglandin E2 impairs CD4+ T cell activation by inhibition of lck: implications in Hodgkin's lymphoma

31 March 2020

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RNA fingerprints provide direct evidence for the inhibitory role of TGF and PD-1 on CD4+ T cells in Hodgkin lymphoma

31 March 2020

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PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma.

31 March 2020

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Infectious Mononucleosis, Childhood Social Environment, and Risk of Hodgkin Lymphoma

31 March 2020

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Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction

31 March 2020

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EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency

31 March 2020

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Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines

31 March 2020

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Detection of genomic imbalances in microdissected Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma by array-based comparative genomic hybridization.

31 March 2020

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BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas

31 March 2020

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MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg cells: a potential pathogenetic lesion in Hodgkin lymphomas

31 March 2020

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Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells

31 March 2020

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12 December 2020

Common features and differences in the transcriptome of large cell anaplastic lymphoma and classical Hodgkin's lymphoma.

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12 December 2020

Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils

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12 December 2020

Gene rearrangement and comparative genomic hybridization studies of classic Hodgkin lymphoma expressing T-cell antigens

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12 December 2020

Detection of clonal T-cell receptor gamma-chain gene rearrangements in Reed-Sternberg cells of classic Hodgkin disease

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12 December 2020

Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma

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12 December 2020

Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma.

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12 December 2020

Molecular single-cell analysis of the clonal relationship of small Epstein-Barr virus-infected cells and Epstein-Barr virus-harboring Hodgkin and Reed/Sternberg cells in Hodgkin disease

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12 December 2020

Pathogenesis of classical and lymphocyte-predominant Hodgkin lymphoma

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12 December 2020

Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines

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12 December 2020

Frequent expression of the B-cell-specific activator protein in Reed-Sternberg cells of classical Hodgkin's disease provides further evidence for its B-cell origin

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12 December 2020

Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells.

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12 December 2020

Expression status of BCL-6 and syndecan-1 identifies distinct histogenetic subtypes of Hodgkin's disease.

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12 December 2020

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections

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12 December 2020

Comprehensive analysis of homeobox genes in Hodgkin lymphoma cell lines identifies dysregulated expression of HOXB9 mediated via ERK5 signaling and BMI1.

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12 December 2020

Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease

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12 December 2020

Epidemiology of Hodgkin's disease

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12 December 2020

Human eosinophils express functional CD30 ligand and stimulate proliferation of a Hodgkin's disease cell line

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12 December 2020

Oct-2 and Bob-1 deficiency in Hodgkin and Reed Sternberg cells.

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12 December 2020

European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes

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12 December 2020

CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease.

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12 December 2020

Identifiers

DOI

10.1038/NRC2542

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19 August 2017

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