(Q37359000)

19 August 2017

1 reference

title

Dysrulation of T cell peripheral tolerance in type 1 diabetes (English)

1 reference

19 August 2017

0 references

R Tisch

1

1 reference

19 August 2017

B Wang

series ordinal

2

1 reference

19 August 2017

publication date

1 January 2008

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19 August 2017

published in

Advances in Immunology

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19 August 2017

volume

100

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19 August 2017

page(s)

125-149

1 reference

Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4+CD25+ T-cell-mediated regulation and type 1 diabetes development in NOD mice.

19 August 2017

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The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice

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Deficient activation and resistance to activation-induced apoptosis of CD8+ T cells is associated with defective peripheral tolerance in nonobese diabetic mice.

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Role of PTPN22 in type 1 diabetes and other autoimmune diseases

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7 January 2021

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes

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7 January 2021

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Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

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7 January 2021

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

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7 January 2021

Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

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7 January 2021

Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21.

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7 January 2021

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

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7 January 2021

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

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7 January 2021

Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells

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7 January 2021

The kinetic-segregation model: TCR triggering and beyond

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7 January 2021

Defect in activation-induced cell death in non-obese diabetic (NOD) T lymphocytes.

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7 January 2021

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

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7 January 2021

The dichotomous role of IL-2: tolerance versus immunity.

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7 January 2021

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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7 January 2021

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

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7 January 2021

A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes.

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7 January 2021

Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice

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7 January 2021

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

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7 January 2021

A closer look at homeostatic proliferation of CD4+ T cells: costimulatory requirements and role in memory formation.

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7 January 2021

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion

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7 January 2021

Phenotypic and functional analysis of CD8(+) T cells undergoing peripheral deletion in response to cross-presentation of self-antigen.

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7 January 2021

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

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7 January 2021

Kinetics of costimulatory molecule expression by T cells and dendritic cells during the induction of tolerance versus immunity in vivo

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7 January 2021

Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes

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7 January 2021

The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice

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7 January 2021

Control of regulatory T cell development by the transcription factor Foxp3

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7 January 2021

CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects

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7 January 2021

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

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7 January 2021

Tissue expression of PD-L1 mediates peripheral T cell tolerance.

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7 January 2021

An essential role for Scurfin in CD4+CD25+ T regulatory cells

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7 January 2021

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

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7 January 2021

Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

1 reference

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7 January 2021

Increased nonobese diabetic Th1:Th2 (IFN-gamma:IL-4) ratio is CD4+ T cell intrinsic and independent of APC genetic background

1 reference

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7 January 2021

Checkpoint blockade in cancer immunotherapy

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7 January 2021

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

CTLA-4 in autoimmune diseases--a general susceptibility gene to autoimmunity?

1 reference

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7 January 2021

Toward an understanding of NKT cell biology: progress and paradoxes

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7 January 2021

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

1 reference

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7 January 2021

IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes

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7 January 2021

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Aire regulates negative selection of organ-specific T cells

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7 January 2021

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

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7 January 2021

Distinct pathways for NF-kappa B regulation are associated with aberrant macrophage IL-12 production in lupus- and diabetes-prone mouse strains

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7 January 2021

Lymphopenia-driven CD8(+) T cells are resistant to antigen-induced tolerance in NOD.scid mice.

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7 January 2021

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

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7 January 2021

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes

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7 January 2021

A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells

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7 January 2021

Genetic susceptibility to type 1 diabetes

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7 January 2021

T cell homeostasis in tolerance and immunity

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7 January 2021

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7 January 2021

Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4+ CD25+ Foxp3+ regulatory T cells.

1 reference

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7 January 2021

IDO expression by dendritic cells: tolerance and tryptophan catabolism

1 reference

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7 January 2021

Abnormal NF-kappa B function characterizes human type 1 diabetes dendritic cells and monocytes

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7 January 2021

Interleukin-10 and the interleukin-10 receptor

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7 January 2021

E3 ubiquitin ligases as T cell anergy factors.

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7 January 2021

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

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7 January 2021

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

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7 January 2021

Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity

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7 January 2021

Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets

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7 January 2021

Dendritic cells and macrophages are essential for the retention of lymphocytes in (peri)-insulitis of the nonobese diabetic mouse: a phagocyte depletion study

1 reference

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7 January 2021

Regulation of type 1 diabetes by NKT cells.

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7 January 2021

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

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7 January 2021

PD-1 and PD-1 ligands: from discovery to clinical application

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7 January 2021

Recent advances in the immunogenetics of human type 1 diabetes

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7 January 2021

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

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7 January 2021

IL-21 modulates CD4+ CD25+ regulatory T-cell homeostasis in experimental autoimmune encephalomyelitis

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7 January 2021

Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function

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7 January 2021

Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes

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7 January 2021

Lymphoid organs contain diverse cells expressing self-molecules

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7 January 2021

Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

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7 January 2021

Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.

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7 January 2021

Tolerogenic dendritic cells: cytokine modulation comes of age.

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7 January 2021

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

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7 January 2021

Etiology of autoimmunity

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7 January 2021

Soluble CTLA-4 in autoimmune thyroid diseases: relationship with clinical status and possible role in the immune response dysregulation.

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7 January 2021

The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse.

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7 January 2021

NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages.

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7 January 2021

Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells

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7 January 2021

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

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7 January 2021

Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

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7 January 2021

From vanilla to 28 flavors: multiple varieties of T regulatory cells

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7 January 2021

Prevention of diabetes in NOD mice by a mutated I-Ab transgene.

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7 January 2021

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

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7 January 2021

Positive and negative selection of T cells

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7 January 2021

Dendritic cells: understanding immunogenicity

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7 January 2021

The innate functions of dendritic cells in peripheral lymphoid tissues.

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7 January 2021

In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket

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7 January 2021

Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition

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7 January 2021

Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?

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7 January 2021

The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model.

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7 January 2021

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

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7 January 2021

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

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7 January 2021

Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse

1 reference

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7 January 2021

B cells are crucial for determinant spreading of T cell autoimmunity among beta cell antigens in diabetes-prone nonobese diabetic mice

1 reference

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7 January 2021

Insulin-dependent diabetes mellitus

1 reference

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7 January 2021

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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7 January 2021

Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models

1 reference

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7 January 2021

Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.

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7 January 2021

Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?

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7 January 2021

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

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7 January 2021

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

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7 January 2021

Good riddance: Thymocyte clonal deletion prevents autoimmunity

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7 January 2021

IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells

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7 January 2021

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

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7 January 2021

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

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7 January 2021

IL-1beta, IFN-gamma and TNF-alpha increase vulnerability of pancreatic beta cells to autoimmune destruction

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7 January 2021

Immunoregulation of dendritic cells

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7 January 2021

CTLA-4 ligation blocks CD28-dependent T cell activation

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7 January 2021

Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Increased NF-kappa B activity in B cells and bone marrow-derived dendritic cells from NOD mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Genetic control of autoimmune diabetes in the NOD mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Type 1 diabetes genes and pathways shared by humans and NOD mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Homeostatic proliferation is a barrier to transplantation tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Presence of diabetes-inhibiting, glutamic acid decarboxylase-specific, IL-10-dependent, regulatory T cells in naive nonobese diabetic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Characterization of monocyte-derived dendritic cells in recent-onset diabetes mellitus type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

Defective central tolerance induction in NOD mice: genomics and genetics

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900805-5

7 January 2021

10.1016/S0065-2776(08)00805-5

Identifiers

DOI

1 reference

19 August 2017

1 reference