(Q37373364)

20 August 2017

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title

Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease (English)

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20 August 2017

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Laura Bica

1

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20 August 2017

Peter J Crouch

series ordinal

2

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20 August 2017

Roberto Cappai

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3

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20 August 2017

Anthony R White

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4

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20 August 2017

12 December 2008

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20 August 2017

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20 August 2017

5

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20 August 2017

2

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20 August 2017

134-142

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The public health impact of Alzheimer's disease, 2000-2050: potential implication of treatment advances

20 August 2017

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

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Different processing of Alzheimer's beta-protein precursor in the vessel wall of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type.

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

21 January 2018

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Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

21 January 2018

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

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The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.

21 January 2018

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

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Correlations of synaptic and pathological markers with cognition of the elderly

21 January 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

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Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization

21 January 2018

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

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Rapid induction of Alzheimer A beta amyloid formation by zinc.

21 January 2018

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

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Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

21 January 2018

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Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

21 January 2018

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Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

21 January 2018

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Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.

21 January 2018

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Beta-amyloid, neuronal death and Alzheimer's disease

21 January 2018

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Neurodegenerative tauopathies

21 January 2018

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Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

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Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.

21 January 2018

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The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation.

21 January 2018

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

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Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5.

21 January 2018

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The role and mechanism of metal ions and their complexes in enhancing damage in biological systems or in protecting these systems from the toxicity of O2-.

21 January 2018

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

21 January 2018

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Metals, toxicity and oxidative stress

21 January 2018

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Therapeutic treatments for Alzheimer's disease based on metal bioavailability

21 January 2018

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Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

21 January 2018

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Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease

21 January 2018

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Amyloid beta protein enhances the survival of hippocampal neurons in vitro

21 January 2018

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Beta-amyloid protein promotes neuritic branching in hippocampal cultures

21 January 2018

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Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

21 January 2018

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Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth

21 January 2018

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Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

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Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

21 January 2018

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Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta

21 January 2018

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Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

21 January 2018

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Metals in Alzheimer's and Parkinson's diseases

21 January 2018

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Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders

21 January 2018

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Ctr1 and its role in body copper homeostasis.

21 January 2018

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Metallochaperones, an intracellular shuttle service for metal ions

21 January 2018

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The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene

21 January 2018

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Isolation of a partial candidate gene for Menkes disease by positional cloning

21 January 2018

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Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

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Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

21 January 2018

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Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.

21 January 2018

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Correlations of regional postmortem enzyme activities with premortem local glucose metabolic rates in Alzheimer's disease.

21 January 2018

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Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

21 January 2018

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Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

21 January 2018

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Copper-Zinc Superoxide Dismutase Affects Akt Activation After Transient Focal Cerebral Ischemia in Mice

21 January 2018

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Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease

21 January 2018

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Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype.

21 January 2018

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Increased levels of superoxide in brains from old female rats

21 January 2018

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Copper selectively triggers beta-sheet assembly of an N-terminally truncated amyloid beta-peptide beginning with Glu3.

21 January 2018

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Metals and amyloid-beta in Alzheimer's disease

21 January 2018

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Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability

21 January 2018

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Zinc-specific autometallographic in vivo selenium methods: tracing of zinc-enriched (ZEN) terminals, ZEN pathways, and pools of zinc ions in a multitude of other ZEN cells

21 January 2018

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

21 January 2018

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Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

21 January 2018

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The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

21 January 2018

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Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

21 January 2018

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Increased nigral iron content in postmortem parkinsonian brain.

21 January 2018

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Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

21 January 2018

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Iron in the basal ganglia in Parkinson's disease. An in vitro study using extended X-ray absorption fine structure and cryo-electron microscopy

21 January 2018

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Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex

21 January 2018

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Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol

21 January 2018

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Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

21 January 2018

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Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

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Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

21 January 2018

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Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model

21 January 2018

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Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

21 January 2018

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Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species

21 January 2018

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Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: the lack of effect of ERK in p53 mediated copper induced apoptosis

21 January 2018

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Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation

21 January 2018

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Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor

21 January 2018

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Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation

21 January 2018

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Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

21 January 2018

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Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity

21 January 2018

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Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis).

21 January 2018

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Neuronal life and death: an essential role for the p53 family

21 January 2018

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Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships

21 January 2018

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Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

21 January 2018

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Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

21 January 2018

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Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide

21 January 2018

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Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden.

21 January 2018

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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

21 January 2018

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Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β

21 January 2018

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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

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Obligate anaerobe or not?

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B816577G

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20 August 2017

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