(Q37379919)

English

Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine

scientific article published on 10 October 2016

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scholarly article

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Europe PubMed Central

PMC publication ID

20 August 2017

Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

crystal structure

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

9

object named as

Jan Tytgat

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

author name string

Mieke Nys

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Eveline Wijckmans

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Ana Farinha

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Özge Yoluk

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Magnus Andersson

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Marijke Brams

6

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Radovan Spurny

7

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Steve Peigneur

8

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Erik Lindahl

10

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Chris Ulens

11

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

language of work or name

0 references

publication date

10 October 2016

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

113

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

43

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

E6696-E6703

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels.

1 reference

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6 September 2017

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

1 reference

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6 September 2017

Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel

1 reference

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6 September 2017

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine

1 reference

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6 September 2017

Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.

1 reference

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6 September 2017

Glycine receptor mechanism elucidated by electron cryo-microscopy

1 reference

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6 September 2017

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.

1 reference

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6 September 2017

Genuine open form of the pentameric ligand-gated ion channel GLIC.

1 reference

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6 September 2017

The prokaryote ligand-gated ion channel ELIC captured in a pore blocker-bound conformation by the Alzheimer's disease drug memantine

1 reference

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6 September 2017

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.

1 reference

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6 September 2017

X-ray structure of the mouse serotonin 5-HT3 receptor

1 reference

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6 September 2017

Crystal structure of a human GABAA receptor

1 reference

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6 September 2017

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera

1 reference

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6 September 2017

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

A locally closed conformation of a bacterial pentameric proton-gated ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Principles of activation and permeation in an anion-selective Cys-loop receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Overview of the CCP4 suite and current developments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

The structural basis of function in Cys-loop receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Improved side-chain torsion potentials for the Amber ff99SB protein force field

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Features and development of Coot

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Binding, activation and modulation of Cys-loop receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

MolProbity: all-atom structure validation for macromolecular crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Fpocket: an open source platform for ligand pocket detection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Fifty years chlorpromazine: a historical perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Protein structure modeling with MODELLER

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Canonical sampling through velocity rescaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Structure and gating mechanism of the acetylcholine receptor pore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Inhibition of human alpha1E subunit-mediated ca2+ channels by the antipsychotic agent chlorpromazine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

VMD: visual molecular dynamics

1 reference

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6 September 2017

Characterization of inhibition by haloperidol and chlorpromazine of a voltage-activated K+ current in rat phaeochromocytoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Ultraviolet light-induced labeling by noncompetitive blockers of the acetylcholine receptor from Torpedo marmorata

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Quaternary structure of the acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes

1 reference

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6 September 2017

The TiPS lecture. The nicotinic acetylcholine receptor: an allosteric protein prototype of ligand-gated ion channels

1 reference

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6 September 2017

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

6 September 2017

Brain dopamine receptors

1 reference

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14 September 2017

[(3)H]chlorpromazine photolabeling of the torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

28 September 2017

Binding sites for exogenous and endogenous non-competitive inhibitors of the nicotinic acetylcholine receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

26 June 2018

Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

26 June 2018

The effects of neuroleptic and tricyclic compounds on BKCa channel activity in rat isolated cortical neurones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

26 June 2018

Radioligand binding and photoaffinity labelling studies show a direct interaction of phenothiazines at 5-HT3 receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

26 June 2018

Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature

1 reference

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26 June 2018

Non-competitive inhibition of GABA currents by phenothiazines in cultured chick spinal cord and rat hippocampal neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

26 June 2018

Neuroleptics decrease calcium-activated potassium conductance in hippocampal pyramidal cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

26 June 2018

The noncompetitive blocker [(3)H]chlorpromazine labels segment M2 but not segment M1 of the nicotinic acetylcholine receptor alpha-subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

26 June 2018

The chlorpromazine enigma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

2 September 2018

Chlorpromazine and QX222 block 5-HT3 receptors in N1E-115 neuroblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

2 September 2018

Inhibition of the GABA receptor-gated chloride ion channel in brain by noncompetitive inhibitors of the nicotinic receptor-gated cation channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5087063

2 September 2018

Preservation and staining of myelinated nerve fibers.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1603101113

21 January 2018

Acetylcholine receptor channel imaged in the open state

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1603101113

21 January 2018

Substituted-cysteine accessibility method

1 reference

https://pubmed.ncbi.nlm.nih.gov/27791038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chlorpromazine inhibits miniature GABAergic currents by reducing the binding and by increasing the unbinding rate of GABAA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27791038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drugs, neurotransmitters, and schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/27791038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Automatic GROMACS topology generation and comparisons of force fields for solvation free energy calculations

1 reference

https://pubmed.ncbi.nlm.nih.gov/27791038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocking of the nicotinic acetylcholine receptor ion channel by chlorpromazine, a noncompetitive inhibitor: A molecular dynamics simulation study

1 reference

https://pubmed.ncbi.nlm.nih.gov/27791038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the beta and delta chains

1 reference

https://pubmed.ncbi.nlm.nih.gov/27791038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of chlorpromazine and phencyclidine on mouse C2 acetylcholine receptor kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/27791038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1603101113

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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