(Q37391029)

20 August 2017

1 reference

title

Targeting the tumour stroma to increase efficacy of chemo- and radiotherapy (English)

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Adaptive radiation therapy

20 August 2017

main subject

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author name string

Chometon G

series ordinal

1

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20 August 2017

Jendrossek V

series ordinal

2

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20 August 2017

publication date

1 February 2009

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Clinical and Translational Oncology

20 August 2017

published in

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20 August 2017

volume

11

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20 August 2017

issue

2

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20 August 2017

page(s)

75-81

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https://scigraph.springernature.com/pub.10.1007/s12094-009-0317-y

20 August 2017

exact match

0 references

cites work

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Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression

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Abnormalities of Basement Membrane on Blood Vessels and Endothelial Sprouts in Tumors

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Radiosensitization of human vascular endothelial cells through Hsp90 inhibition with 17-N-allilamino-17-demethoxygeldanamycin

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Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition

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12 December 2020

Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model

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12 December 2020

Social controls on cell survival and cell death

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12 December 2020

Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium

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12 December 2020

Tumor induction of VEGF promoter activity in stromal cells

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Structure and biological activity of the extracellular matrix

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Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation

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Supramolecular assembly of basement membranes

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Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model.

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Friends or foes - bipolar effects of the tumour stroma in cancer

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A microenvironmental model of carcinogenesis.

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Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis.

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Death and anti-death: tumour resistance to apoptosis

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Promoting apoptosis as a strategy for cancer drug discovery

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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Efficacy of a triple treatment with irradiation, agonistic TRAIL receptor antibodies and EGFR blockade

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Integrin connections map: to infinity and beyond

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Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions

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The Hallmarks of Cancer

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12 December 2020

Fibroblasts in cancer

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12 December 2020

Function and interactions of integrins

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12 December 2020

Basement membranes: structure, assembly and role in tumour angiogenesis

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12 December 2020

Immunology for the next generation.

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12 December 2020

Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?

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12 December 2020

Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo

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12 December 2020

The role of apoptosis in cancer development and treatment response

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12 December 2020

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12 December 2020

Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines

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12 December 2020

Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells

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12 December 2020

Cell adhesion-mediated drug resistance (CAM-DR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR/ABL inhibition, cytotoxic drugs, and gamma-irradiation

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12 December 2020

HIF-1 and tumour radiosensitivity

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Integrin agonists as adjuvants in chemotherapy for melanoma.

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Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

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Disruption of endothelial cell interactions with the novel HU177 cryptic collagen epitope inhibits angiogenesis.

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The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis

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Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors.

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beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury.

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12 December 2020

Intrinsic tumour suppression

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12 December 2020

Engaging the vascular component of the tumor response

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12 December 2020

A genetic model for colorectal tumorigenesis

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12 December 2020

The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

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12 December 2020

Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells

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12 December 2020

The microenvironment of the tumour-host interface

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12 December 2020

Integrins: bidirectional, allosteric signaling machines

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12 December 2020

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Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

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12 December 2020

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12 December 2020

Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo

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12 December 2020

Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake

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12 December 2020

Targeting a tumor-specific laminin domain critical for human carcinogenesis

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12 December 2020

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

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12 December 2020

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

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12 December 2020

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12 December 2020

Fibronectin Protects Prostate Cancer Cells from Tumor Necrosis Factor-α-induced Apoptosis via the AKT/Survivin Pathway

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12 December 2020

Disruption of epithelial cell-matrix interactions induces apoptosis

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12 December 2020

Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells

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12 December 2020

The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1.

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12 December 2020

The myofibroblast: one function, multiple origins

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12 December 2020

Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases

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12 December 2020

XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer

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12 December 2020

Direct targeting of alphavbeta3 integrin on tumor cells with a monoclonal antibody, Abegrin

1 reference

12 December 2020

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

1 reference

12 December 2020

Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis

1 reference

12 December 2020

Blockade of the Stromal Cell–Derived Factor-1/CXCR4 Axis AttenuatesIn vivoTumor Growth by Inhibiting Angiogenesis in a Vascular Endothelial Growth Factor–Independent Manner

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12 December 2020

Stromal fibroblasts in cancer initiation and progression

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12 December 2020

Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death.

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12 December 2020

Reprogramming metastatic tumour cells with embryonic microenvironments

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12 December 2020

Direct involvement of breast tumor fibroblasts in the modulation of tamoxifen sensitivity

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12 December 2020

Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways

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12 December 2020

Integrins and anoikis

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12 December 2020

Integrin alphavbeta3-targeted radioimmunotherapy of glioblastoma multiforme

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12 December 2020

Role of the tumor microenvironment in mediating de novo resistance to drugs and physiological mediators of cell death

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12 December 2020

A function blocking anti-mouse integrin alpha5beta1 antibody inhibits angiogenesis and impedes tumor growth in vivo

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12 December 2020

A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer

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12 December 2020

PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment

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12 December 2020

Components of cell-matrix adhesions

1 reference

12 December 2020

Proliferation, cell cycle and apoptosis in cancer

1 reference

12 December 2020

Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors

1 reference

12 December 2020

Integrin signalling during tumour progression

1 reference

12 December 2020

Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells.

1 reference

12 December 2020

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

1 reference

12 December 2020

Role of integrins in regulating epidermal adhesion, growth and differentiation

1 reference

12 December 2020

Integrin regulation of growth factor receptors

1 reference

12 December 2020

1 reference

12 December 2020

Host acid sphingomyelinase regulates microvascular function not tumor immunity.

1 reference

12 December 2020

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

1 reference

12 December 2020

Type VII collagen is required for Ras-driven human epidermal tumorigenesis.

1 reference

12 December 2020

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

1 reference

12 December 2020

A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription

1 reference

12 December 2020

Fibronectin alters cell survival and intracellular signaling of confluent A549 cultures after irradiation

1 reference

12 December 2020

10.1007/S12094-009-0317-Y

Identifiers

DOI

1 reference

20 August 2017

1 reference