(Q37424883)

20 August 2017

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title

DNA hypomethylation in the origin and pathogenesis of human diseases (English)

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20 August 2017

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Frederick A Beland

2

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author name string

Igor P Pogribny

series ordinal

1

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20 August 2017

publication date

27 March 2009

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Cellular and Molecular Life Sciences

20 August 2017

published in

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20 August 2017

volume

66

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20 August 2017

issue

14

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20 August 2017

page(s)

2249-2261

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Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

20 August 2017

cites work

1 reference

12 December 2020

Loss of methylation at chromosome 11p15.5 is common in human adult tumors

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12 December 2020

Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1

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12 December 2020

Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis

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12 December 2020

Methyl groups in carcinogenesis: effects on DNA methylation and gene expression

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12 December 2020

DNA hypomethylation and methyltransferase expression in atherosclerotic lesions

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12 December 2020

Hypomethylation of DNA: a possible nongenotoxic mechanism underlying the role of cell proliferation in carcinogenesis

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12 December 2020

Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma

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12 December 2020

Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs

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12 December 2020

A mammalian protein with specific demethylase activity for mCpG DNA.

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12 December 2020

DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage

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12 December 2020

DNMT cooperativity--the developing links between methylation, chromatin structure and cancer.

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12 December 2020

Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation

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12 December 2020

Promoter hypomethylation regulates CD133 expression in human gliomas

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12 December 2020

DNA hypomethylation and ovarian cancer biology.

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12 December 2020

FGFR1 over-expression in primary rhabdomyosarcoma tumors is associated with hypomethylation of a 5' CpG island and abnormal expression of the AKT1, NOG, and BMP4 genes

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12 December 2020

Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease

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12 December 2020

Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells

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12 December 2020

Cytosine methylation and the ecology of intragenomic parasites

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12 December 2020

Chemical-induced DNA damage and human cancer risk

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12 December 2020

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

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12 December 2020

A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice

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12 December 2020

Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient.

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12 December 2020

DNA methylation: its contribution to systemic lupus erythematosus

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12 December 2020

Potential link between estrogen receptor-alpha gene hypomethylation and uterine fibroid formation

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12 December 2020

DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E.

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12 December 2020

DNA methylation and human disease

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12 December 2020

Reduced genomic 5-methylcytosine content in human colonic neoplasia

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12 December 2020

S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production.

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12 December 2020

DNA hypomethylation on pericentromeric satellite regions significantly correlates with loss of heterozygosity on chromosome 9 in urothelial carcinomas

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12 December 2020

Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline

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12 December 2020

Hypomethylated P4 promoter induces expression of the insulin-like growth factor-II gene in hepatocellular carcinoma in a Chinese population

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12 December 2020

Age-related macular degeneration

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12 December 2020

Changes in DNA repair during aging.

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

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12 December 2020

Genome-wide hypomethylation in hepatocellular carcinogenesis.

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12 December 2020

Cytosine methylation profiling of cancer cell lines.

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12 December 2020

The epigenomics of cancer

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12 December 2020

Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder

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12 December 2020

Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer

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12 December 2020

Cell-Type-Specific Repression of the Maspin Gene Is Disrupted Frequently by Demethylation at the Promoter Region in Gastric Intestinal Metaplasia and Cancer Cells

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12 December 2020

Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene

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12 December 2020

Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers

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12 December 2020

Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.

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12 December 2020

Long term low-dose arsenic exposure induces loss of DNA methylation

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12 December 2020

Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer

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12 December 2020

DNA methylation, smooth muscle cells, and atherogenesis

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12 December 2020

Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex

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12 December 2020

Diethanolamine induces hepatic choline deficiency in mice

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12 December 2020

The role of CpG islands hypomethylation and abnormal expression of neuronal protein synuclein-gamma (SNCG) in ovarian cancer

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12 December 2020

Tumorigenesis: the adaptation of mammalian cells to sustained stress environment by epigenetic alterations and succeeding matched mutations

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12 December 2020

Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study

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12 December 2020

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

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12 December 2020

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

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12 December 2020

Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).

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12 December 2020

Lipotrope deficiency and persistent changes in DNA methylation. Lipotrope deficiency and DNA methylation.

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12 December 2020

Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues

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12 December 2020

Reelin promoter hypermethylation in schizophrenia

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12 December 2020

Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults

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12 December 2020

DNA hypomethylation of CAGE promotors in squamous cell carcinoma of uterine cervix.

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12 December 2020

Large-scale structure of genomic methylation patterns

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12 December 2020

Hyperhomocysteinemia, DNA methylation and vascular disease

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12 December 2020

The Hallmarks of Cancer

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12 December 2020

The 5-methylcytosine content of DNA from human tumors

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12 December 2020

Can reduced folic acid and vitamin B12 levels cause deficient DNA methylation producing mutations which initiate atherosclerosis?

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12 December 2020

The colorful history of active DNA demethylation.

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12 December 2020

Promoter methylation of cyclin D2 gene in gastric carcinoma

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12 December 2020

Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine

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12 December 2020

Epigenetics and cancer: implications for drug discovery and safety assessment

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12 December 2020

The 5-methylcytosine content of highly repeated sequences in human DNA.

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12 December 2020

Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice.

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12 December 2020

Transient cyclical methylation of promoter DNA.

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12 December 2020

The 5-lipoxygenase promoter is regulated by DNA methylation

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12 December 2020

DNA damage, cellular senescence and organismal ageing: causal or correlative?

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12 December 2020

Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma.

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12 December 2020

An overview of cardiovascular disease burden in the United States

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12 December 2020

Mechanisms of DNA Damage, DNA Hypomethylation, and Tumor Progression in the Folate/Methyl-Deficient Rat Model of Hepatocarcinogenesis

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12 December 2020

DNA hypomethylation and human diseases.

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12 December 2020

Analysis of putative RNase sensitivity and protease insensitivity of demethylation activity in extracts from rat myoblasts

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12 December 2020

Role for DNA methylation in genomic imprinting

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12 December 2020

Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric carcinomas

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12 December 2020

Lsh is involved in de novo methylation of DNA

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12 December 2020

A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters

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12 December 2020

Emerging role of epigenetics in the actions of alcohol

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12 December 2020

Environmental exposure measurement in cancer epidemiology

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12 December 2020

5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C mutations are associated with DNA hypomethylation

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12 December 2020

DNA methylation and autoimmune disease

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12 December 2020

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

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12 December 2020

Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays.

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12 December 2020

Free radical adducts induce alterations in DNA cytosine methylation

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12 December 2020

Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression

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12 December 2020

Lipoxygenase pathways in atherogenesis

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12 December 2020

Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells

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12 December 2020

Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation

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12 December 2020

Hypomethylation of hepatocyte nuclear factor-1beta (HNF-1beta) CpG island in clear cell carcinoma of the ovary

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12 December 2020

Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases

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12 December 2020

Epigenetic gene silencing in cancer: the DNA hypermethylome

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12 December 2020

Molecular mechanisms of alcohol-mediated carcinogenesis

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12 December 2020

Epigenetic mechanisms in mammals

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12 December 2020

DNA methylation landscapes: provocative insights from epigenomics

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12 December 2020

Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia

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12 December 2020

Hypomethylation and aberrant expression of the glioma pathogenesis-related 1 gene in Wilms tumors

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12 December 2020

Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements

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12 December 2020

Epigenetic drivers and genetic passengers on the road to cancer.

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12 December 2020

TCL1 is activated by chromosomal rearrangement or by hypomethylation

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12 December 2020

Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxin

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12 December 2020

Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models

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12 December 2020

NGALR is overexpressed and regulated by hypomethylation in esophageal squamous cell carcinoma

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12 December 2020

Hypomethylation of urokinase (uPA) promoter in breast and prostate cancer: prognostic and therapeutic implications.

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12 December 2020

BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection

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12 December 2020

A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer

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12 December 2020

Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis.

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12 December 2020

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

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12 December 2020

DNA methylation-dependent regulation of BORIS/CTCFL expression in ovarian cancer

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12 December 2020

Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit

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12 December 2020

Roles for nutrients in epigenetic events.

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12 December 2020

Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases

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12 December 2020

The impact of metabolism on DNA methylation

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12 December 2020

Biology of atherosclerotic plaque formation: possible role of growth factors in lesion development and the potential impact of soy.

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12 December 2020

Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2

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12 December 2020

Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression

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12 December 2020

LSH cooperates with DNA methyltransferases to repress transcription

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12 December 2020

bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia

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12 December 2020

Transcriptional regulation of 15-lipoxygenase expression by promoter methylation.

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12 December 2020

X chromosome inactivation and DNA methylation

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12 December 2020

Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.

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12 December 2020

Loss of imprinting of IGF2 as an epigenetic marker for the risk of human cancer

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12 December 2020

Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia.

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12 December 2020

Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancer

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12 December 2020

Induction of Tumors in Mice by Genomic Hypomethylation

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12 December 2020

Cyclical DNA methylation of a transcriptionally active promoter

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12 December 2020

Epigenetics in human disease and prospects for epigenetic therapy

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12 December 2020

Epigenetics and aging: the targets and the marks

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12 December 2020

Active cytosine demethylation triggered by a nuclear receptor involves DNA strand breaks.

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12 December 2020

Nutrition and aberrant DNA methylation patterns in atherosclerosis: more than just hyperhomocysteinemia?

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12 December 2020

Methylation-induced repression--belts, braces, and chromatin

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12 December 2020

DNA methylation profile at the DNMT3L promoter: a potential biomarker for cervical cancer

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12 December 2020

Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: prevention by methionine

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12 December 2020

Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L.

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12 December 2020

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

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12 December 2020

DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development.

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12 December 2020

Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope

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12 December 2020

Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters

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12 December 2020

DNA Methylation and Gene Function

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12 December 2020

Hypomethylation-induced expression of S100A4 in endometrial carcinoma

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12 December 2020

Accumulation of small murine minor satellite transcripts leads to impaired centromeric architecture and function

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12 December 2020

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

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12 December 2020

Perturbation of maintenance and de novo DNA methylation in vitro by UVB (280-340 nm)-induced pyrimidine photodimers

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12 December 2020

Translating the Histone Code

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12 December 2020

When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease

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12 December 2020

Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines

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12 December 2020

The mammalian epigenome

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12 December 2020

Epigenetics at the epicenter of modern medicine

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12 December 2020

Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids

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12 December 2020

Comprehensive analysis of CpG islands in human chromosomes 21 and 22

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12 December 2020

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

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12 December 2020

Hypomethylation of PRAME is responsible for its aberrant overexpression in human malignancies

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12 December 2020

Loss of imprinting and cancer

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12 December 2020

Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine

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12 December 2020

Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma

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12 December 2020

Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions

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12 December 2020

Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers

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12 December 2020

Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia

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12 December 2020

Disruption of cell-type-specific methylation at the Maspin gene promoter is frequently involved in undifferentiated thyroid cancers

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12 December 2020

Promoter hypomethylation of the N-acetyltransferase 1 gene in breast cancer.

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12 December 2020

P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation.

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12 December 2020

High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer

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12 December 2020

Expression of CYP2W1 in colon tumors: regulation by gene methylation.

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12 December 2020

The essentials of DNA methylation

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12 December 2020

Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis

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12 December 2020

Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer

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12 December 2020

Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage

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12 December 2020

Hypomethylation of the decorin proteoglycan gene in human colon cancer

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12 December 2020

Rapid DNA methylation changes after exposure to traffic particles

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12 December 2020

Cigarette smoke induces demethylation of prometastatic oncogene synuclein-gamma in lung cancer cells by downregulation of DNMT3B.

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12 December 2020

Variable 5-methylcytosine levels in human tumor cell lines and fresh pediatric tumor explants.

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12 December 2020

S-Adenosylmethionine and methylation

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12 December 2020

Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma

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12 December 2020

Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas

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12 December 2020

Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma

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12 December 2020

Hypomethylation: One Side of a Larger Picture

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12 December 2020

Cancer genes and the pathways they control

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12 December 2020

Epigenetic regulation of telomeres in human cancer.

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12 December 2020

Environmental epigenomics and disease susceptibility

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12 December 2020

Homocysteinemia as a risk factor for atherosclerosis: a review

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12 December 2020

Breast cancer epigenetics: normal human mammary epithelial cells as a model system

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12 December 2020

Expression of family A melanoma antigen in human gastric carcinoma.

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12 December 2020

DNA methylation and atherosclerosis

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12 December 2020

DNA hypomethylation is prevalent even in low-grade breast cancers

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12 December 2020

10.1007/S00018-009-0015-5

Identifiers

DOI

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20 August 2017

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