(Q37496596)

English

Production of stable bispecific IgG1 by controlled Fab-arm exchange: scalability from bench to large-scale manufacturing by application of standard approaches.

scientific article published on 22 August 2013

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scholarly article

1 reference

Europe PubMed Central

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8 March 2020

Production of stable bispecific IgG1 by controlled Fab-arm exchange: scalability from bench to large-scale manufacturing by application of standard approaches (English)

1 reference

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8 March 2020

12

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8 March 2020

Paul Whi Parren

15

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8 March 2020

author name string

Michael J Gramer

1

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8 March 2020

Ewald T J van den Bremer

2

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8 March 2020

Muriel D van Kampen

3

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8 March 2020

Amitava Kundu

4

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8 March 2020

Peter Kopfmann

5

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8 March 2020

Eric Etter

6

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8 March 2020

David Stinehelfer

7

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8 March 2020

Justin Long

8

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8 March 2020

Tom Lannom

9

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8 March 2020

Esther H Noordergraaf

10

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8 March 2020

Jolanda Gerritsen

11

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8 March 2020

Janine Schuurman

13

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8 March 2020

Patrick H C van Berkel

14

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8 March 2020

publication date

22 August 2013

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8 March 2020

Monoclonal Antibodies

1 reference

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8 March 2020

5

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8 March 2020

6

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8 March 2020

962-973

1 reference

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8 March 2020

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896610

23 August 2017

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

1 reference

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23 August 2017

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896610

23 August 2017

A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity

1 reference

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23 August 2017

Therapeutic antibodies for autoimmunity and inflammation

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23 August 2017

Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.

1 reference

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23 August 2017

Recent advances in large-scale production of monoclonal antibodies and related proteins

1 reference

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Industrialization of mAb production technology: the bioprocessing industry at a crossroads

1 reference

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23 August 2017

Engineering of stable bispecific antibodies targeting IL-17A and IL-23.

1 reference

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23 August 2017

Bispecific T-cell engaging antibodies for cancer therapy

1 reference

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23 August 2017

Bispecific antibodies for cancer therapy

1 reference

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23 August 2017

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

1 reference

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23 August 2017

Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis

1 reference

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23 August 2017

A revival of bispecific antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896610

23 August 2017

Bispecific human IgG by design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896610

23 August 2017

An efficient route to human bispecific IgG.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896610

23 August 2017

Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896610

23 August 2017

Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896610

6 September 2017

Dual targeting strategies with bispecific antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896610

6 September 2017

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896610

14 September 2017

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896610

14 September 2017

Single variable domain antibody as a versatile building block for the construction of IgG-like bispecific antibodies

1 reference

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14 September 2017

Dual mode of action of a human anti-epidermal growth factor receptor monoclonal antibody for cancer therapy

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14 September 2017

Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

1 reference

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14 September 2017

SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies

1 reference

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2 September 2018

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain.

1 reference

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2 September 2018

Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.

1 reference

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2 September 2018

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

1 reference

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2 September 2018

Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3-CH3 Interaction Strength

1 reference

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21 January 2018

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

1 reference

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Hybrid hybridomas and their use in immunohistochemistry

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23995617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The design and characterization of oligospecific antibodies for simultaneous targeting of multiple disease mediators

1 reference

https://pubmed.ncbi.nlm.nih.gov/23995617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/MABS.26233

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995617%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

Europe PubMed Central

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8 March 2020

1 reference

Europe PubMed Central

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8 March 2020

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