(Q37512907)

1 July 2019

review article

1 reference

title

Cytotoxicity mediated by histone deacetylase inhibitors in cancer cells: mechanisms and potential clinical implications (English)

1 reference

1 July 2019

0 references

David S Schrump

1

1 reference

1 July 2019

language of work or name

English

0 references

publication date

9 June 2009

1 reference

1 July 2019

published in

Clinical Cancer Research

1 reference

1 July 2019

volume

15

1 reference

1 July 2019

issue

12

1 reference

1 July 2019

page(s)

3947-3957

1 reference

1 July 2019

Sequential 5-Aza-2 deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1.

cites work

1 reference

12 December 2020

The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.

1 reference

12 December 2020

Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines

1 reference

12 December 2020

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

1 reference

12 December 2020

The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor alpha-negative breast cancer cells to tamoxifen

1 reference

12 December 2020

Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications

1 reference

12 December 2020

Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1

1 reference

12 December 2020

Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines.

1 reference

12 December 2020

Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells

1 reference

12 December 2020

Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients.

1 reference

12 December 2020

Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells

1 reference

12 December 2020

Histone deacetylase 1 mRNA expression in lung cancer.

1 reference

12 December 2020

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

1 reference

12 December 2020

HDAC6 expression is correlated with better survival in breast cancer.

1 reference

12 December 2020

Apoptotic and autophagic cell death induced by histone deacetylase inhibitors

1 reference

12 December 2020

Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.

1 reference

12 December 2020

Marker genes to predict sensitivity to FK228, a histone deacetylase inhibitor.

1 reference

12 December 2020

Sequential 5-Aza 2'-deoxycytidine/depsipeptide FK228 treatment induces tissue factor pathway inhibitor 2 (TFPI-2) expression in cancer cells.

1 reference

12 December 2020

Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors

1 reference

12 December 2020

Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents

1 reference

12 December 2020

Histone deacetylase-1 and -3 protein expression in human breast cancer: a tissue microarray analysis

1 reference

12 December 2020

Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells

1 reference

12 December 2020

Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin.

1 reference

12 December 2020

Epigenetic modulation of retinoic acid receptor beta2 by the histone deacetylase inhibitor MS-275 in human renal cell carcinoma

1 reference

12 December 2020

Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

1 reference

12 December 2020

Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation

1 reference

12 December 2020

The two faces of NFkappaB in cell survival responses

1 reference

12 December 2020

Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells

1 reference

12 December 2020

Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*.

1 reference

12 December 2020

The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling

1 reference

12 December 2020

Unexpected roles for deacetylation in interferon- and cytokine-induced transcription

1 reference

12 December 2020

Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A.

1 reference

12 December 2020

Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176).

1 reference

12 December 2020

Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).

1 reference

12 December 2020

Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation

1 reference

12 December 2020

Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells

1 reference

12 December 2020

Differential expression of selected histone modifier genes in human solid cancers

1 reference

12 December 2020

Aberrant expression of histone deacetylase 6 in oral squamous cell carcinoma

1 reference

12 December 2020

Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation

1 reference

12 December 2020

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

1 reference

12 December 2020

Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity

1 reference

12 December 2020

A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity

1 reference

12 December 2020

Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function.

1 reference

12 December 2020

Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade

1 reference

12 December 2020

Suberoylanilide hydroxamic acid (vorinostat) represses androgen receptor expression and acts synergistically with an androgen receptor antagonist to inhibit prostate cancer cell proliferation.

1 reference

12 December 2020

p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death

1 reference

12 December 2020

The mammalian epigenome

1 reference

12 December 2020

Chromatin modifications and their function

1 reference

12 December 2020

NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells

1 reference

12 December 2020

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance

1 reference

12 December 2020

Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity

1 reference

12 December 2020

Utilization of chromatin remodeling agents for lung cancer therapy

1 reference

12 December 2020

Role for histone deacetylase 1 in human tumor cell proliferation

1 reference

12 December 2020

HDAC inhibitors: clinical update and mechanism-based potential.

1 reference

12 December 2020

The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells

1 reference

12 December 2020

NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs

1 reference

12 December 2020

Histone deacetylase inhibitors: molecular mechanisms of action

1 reference

12 December 2020

Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90.

1 reference

12 December 2020

Expression profile of class I histone deacetylases in human cancer tissues.

1 reference

12 December 2020

Inhibition of histone deacetylation: a strategy for tumor radiosensitization

1 reference

12 December 2020

Histone deacetylase inhibitor apicidin downregulates DNA methyltransferase 1 expression and induces repressive histone modifications via recruitment of corepressor complex to promoter region in human cervix cancer cells

1 reference

12 December 2020

Inhibitors of histone deacetylases induce tumor-selective cytotoxicity through modulating Aurora-A kinase

1 reference

12 December 2020

Deacetylase inhibition promotes the generation and function of regulatory T cells.

1 reference

12 December 2020

A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors

1 reference

12 December 2020

Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors

1 reference

12 December 2020

NKG2D ligand expression in AML increases in response to HDAC inhibitor valproic acid and contributes to allorecognition by NK-cell lines with single KIR-HLA class I specificities

1 reference

12 December 2020

Modulation of death receptors by cancer therapeutic agents

1 reference

12 December 2020

Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells.

1 reference

12 December 2020

Clinical and molecular responses in lung cancer patients receiving Romidepsin

1 reference

12 December 2020

Histone acetylation is not an accurate predictor of gene expression following treatment with histone deacetylase inhibitors

1 reference

12 December 2020

Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis.

1 reference

12 December 2020

Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors

1 reference

12 December 2020

Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy

1 reference

12 December 2020

Histone deacetylase regulation of immune gene expression in tumor cells

1 reference

12 December 2020

Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells

1 reference

12 December 2020

Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells

1 reference

12 December 2020

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

1 reference

12 December 2020

ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor

1 reference

12 December 2020

Histone deacetylase inhibitor apicidin-mediated drug resistance: involvement of P-glycoprotein

1 reference

12 December 2020

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

1 reference

12 December 2020

Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling

1 reference

12 December 2020

Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter.

1 reference

12 December 2020

Modulation of TRAIL-induced apoptosis by HDAC inhibitors

1 reference

12 December 2020

Inhibition of histone deacetylase1 induces autophagy

1 reference

12 December 2020

Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo

1 reference

12 December 2020

Expression of hypoxia-inducible factor-1alpha, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma: correlation with poor prognosis with possible regulation

1 reference

12 December 2020

Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control

1 reference

12 December 2020

Role of the aggresome pathway in cancer: targeting histone deacetylase 6-dependent protein degradation

1 reference

12 December 2020

Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma

1 reference

12 December 2020

Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition.

1 reference

12 December 2020

Identification of predictive biomarkers for the histone deacetylase inhibitor belinostat in a panel of human cancer cell lines.

1 reference

12 December 2020

Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells

1 reference

12 December 2020

Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model

1 reference

12 December 2020

Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation

1 reference

12 December 2020

Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A.

1 reference

12 December 2020

HDAC4 promotes growth of colon cancer cells via repression of p21.

1 reference

12 December 2020

Modulation of the cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by Zac1 through the antagonistic regulators p53 and histone deacetylase 1 in HeLa Cells

1 reference

12 December 2020

Histone deacetylase inhibitor-induced cellular apoptosis involves stanniocalcin-1 activation.

1 reference

12 December 2020

Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells.

1 reference

12 December 2020

Recognition of NY-ESO-1+ tumor cells by engineered lymphocytes is enhanced by improved vector design and epigenetic modulation of tumor antigen expression

1 reference

12 December 2020

A gene signature-based approach identifies mTOR as a regulator of p73.

1 reference

12 December 2020

Sp1-mediated TRAIL induction in chemosensitization

1 reference

12 December 2020

Aurora A, Aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer

1 reference

12 December 2020

Inhibition of protein deacetylation by trichostatin A impairs microtubule-kinetochore attachment

1 reference

12 December 2020

Molecular basis of the anti-cancer effects of histone deacetylase inhibitors

1 reference

12 December 2020

Postradiation sensitization of the histone deacetylase inhibitor valproic acid

1 reference

12 December 2020

SIRTUIN 1: regulating the regulator

1 reference

12 December 2020

Chromatin-modifying enzymes as therapeutic targets--Part 1

1 reference

12 December 2020

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

1 reference

12 December 2020

Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer

1 reference

12 December 2020

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

1 reference

12 December 2020

Histone deacetylase inhibitors: apoptotic effects and clinical implications (Review).

1 reference

12 December 2020

Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation.

1 reference

12 December 2020

HDAC family: What are the cancer relevant targets?

1 reference

12 December 2020

Histone deacetylase inhibitors in cancer therapy

1 reference

12 December 2020

SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway

1 reference

12 December 2020

Chromatin-modifying enzymes as therapeutic targets--Part 2

1 reference

12 December 2020

Histone deacetylase 2 expression predicts poorer prognosis in oral cancer patients

1 reference

12 December 2020

mTOR regulates autophagy-associated genes downstream of p73.

1 reference

12 December 2020

The role of histone deacetylases in prostate cancer.

1 reference

12 December 2020

Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells

1 reference

12 December 2020

Heat shock protein 90 as a drug target: some like it hot.

1 reference

12 December 2020

Histone deacetylase 8 in neuroblastoma tumorigenesis

1 reference

12 December 2020

The paradox of autophagy and its implication in cancer etiology and therapy

1 reference

12 December 2020

Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer

1 reference

12 December 2020

Histone deacetylase inhibitor induced modulation of anti-estrogen therapy

1 reference

12 December 2020

Dual degradation of aurora A and B kinases by the histone deacetylase inhibitor LBH589 induces G2-M arrest and apoptosis of renal cancer cells.

1 reference

12 December 2020

Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

1 reference

12 December 2020

p62 degradation by autophagy: another way for cancer cells to survive under hypoxia.

1 reference

12 December 2020

Histone deacetylases: salesmen and customers in the post-translational modification market.

1 reference

12 December 2020

Autophagy facilitates the progression of ERalpha-positive breast cancer cells to antiestrogen resistance

1 reference

12 December 2020

Histone modifications dictate specific biological readouts

1 reference

12 December 2020

Histone acetylation: truth of consequences?

1 reference

12 December 2020

The critical role of the class III histone deacetylase SIRT1 in cancer

1 reference

12 December 2020

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

12 December 2020

10.1158/1078-0432.CCR-08-2787

Identifiers

DOI

1 reference

1 July 2019

PMCID

6354580

1 reference

1 July 2019

PubMed ID

19509170

1 reference

1 July 2019