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Ubiquitin-independent p53 proteasomal degradation.
scientific article published on January 2010
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PubMed publication ID
19557012
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review article
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title
Ubiquitin-independent p53 proteasomal degradation
(English)
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PubMed publication ID
19557012
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1 February 2020
author
Peter Tsvetkov
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1
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19557012
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N Reuven
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2
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19557012
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Y Shaul
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3
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19557012
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publication date
1 January 2010
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published in
Cell Death & Differentiation
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PubMed publication ID
19557012
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17
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19557012
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1
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19557012
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103-108
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1 February 2020
exact match
https://scigraph.springernature.com/pub.10.1038/cdd.2009.67
0 references
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Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors
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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction
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Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase).
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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
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Regulation of p53 stability by Mdm2
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7 January 2021
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Mdm2 promotes the rapid degradation of p53
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The ubiquitin ligase COP1 is a critical negative regulator of p53
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20S proteasomes and protein degradation "by default".
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DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation
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Studies on the reaction mechanism of DT diaphorase. Intermediary plateau and trough regions in the initial velocity vs substrate concentration curves
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Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogens
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7 January 2021
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Regulation of genes encoding NAD(P)H:quinone oxidoreductases
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7 January 2021
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NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms
1 reference
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7 January 2021
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NQO1 stabilizes p53 through a distinct pathway
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7 January 2021
based on heuristic
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Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.
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Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems
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P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1
1 reference
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A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73
1 reference
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7 January 2021
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p53-dependent apoptosis and NAD(P)H:quinone oxidoreductase 1.
1 reference
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Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.
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The ubiquitin system
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Subcellular localization of proteasomes and their regulatory complexes in mammalian cells.
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The proteasome: a macromolecular assembly designed for controlled proteolysis
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Proteasomes can degrade a significant proportion of cellular proteins independent of ubiquitination
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https://api.crossref.org/works/10.1038%2FCDD.2009.67
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7 January 2021
based on heuristic
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Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.
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Crossref
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https://api.crossref.org/works/10.1038%2FCDD.2009.67
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7 January 2021
based on heuristic
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p53 contains large unstructured regions in its native state
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Crossref
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https://api.crossref.org/works/10.1038%2FCDD.2009.67
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7 January 2021
based on heuristic
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20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1
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Quinone reductase acts as a redox switch of the 20S yeast proteasome
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Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification
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Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity
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Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins.
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The importance of intrinsic disorder for protein phosphorylation
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Some p53-binding proteins that can function as arbiters of life and death.
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E2F-1 induces the stabilization of p53 but blocks p53-mediated transactivation.
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The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis
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Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
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The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation
1 reference
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Crossref
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Thermodynamic stability of wild-type and mutant p53 core domain
1 reference
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7 January 2021
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p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.
1 reference
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Crossref
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Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain
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Effect of Zn2+on DNA Recognition and Stability of the p53 DNA-Binding Domain†
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Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc.
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Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown
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Crossref
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Mechanism of coupled folding and binding of an intrinsically disordered protein
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7 January 2021
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Post-translational modification of p53 in tumorigenesis
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7 January 2021
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Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6.
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Surfing the p53 network
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7 January 2021
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NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin
1 reference
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7 January 2021
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Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FCDD.2009.67
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7 January 2021
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p53 regulates mitochondrial respiration
1 reference
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Crossref
reference URL
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7 January 2021
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Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene
1 reference
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7 January 2021
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On the Origin of Cancer Cells
1 reference
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7 January 2021
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Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.67
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7 January 2021
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TIGAR, a p53-inducible regulator of glycolysis and apoptosis
1 reference
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reference URL
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7 January 2021
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inferred from DOI database lookup
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.67
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7 January 2021
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inferred from DOI database lookup
NAD+ modulates p53 DNA binding specificity and function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.67
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53, the cellular gatekeeper for growth and division
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.67
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7 January 2021
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inferred from DOI database lookup
The p53 tumor suppressor gene: from molecular biology to clinical investigation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.67
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7 January 2021
based on heuristic
inferred from DOI database lookup
Genome wide identification of recessive cancer genes by combinatorial mutation analysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.67
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypermethylation of NAD(P)H: quinone oxidoreductase 1 (NQO1) gene in human hepatocellular carcinoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.67
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H:quinone oxidoreductase 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.67
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.67
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.67
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/CDD.2009.67
1 reference
stated in
Europe PubMed Central
PubMed publication ID
19557012
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19557012%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
PubMed publication ID
19557012
1 reference
stated in
Europe PubMed Central
PubMed publication ID
19557012
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19557012%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
ResearchGate publication ID
26321274
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