(Q37546119)

20 August 2017

1 reference

title

An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease (English)

1 reference

20 August 2017

0 references

0 references

Bruno P Imbimbo

1

1 reference

ORCID Public Data File 2021

language of work or name

English

0 references

publication date

1 August 2009

1 reference

Expert Opinion on Investigational Drugs

20 August 2017

published in

1 reference

20 August 2017

volume

18

1 reference

20 August 2017

issue

8

1 reference

20 August 2017

page(s)

1147-1168

1 reference

Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis

20 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Molecular recycling within amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Mixed results for disease-modification strategies for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Inflammation in neurodegenerative disease--a double-edged sword

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Cyclooxygenase-1 and -2 in the different stages of Alzheimer's disease pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Colon cancer--understanding how NSAIDs work

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Coxibs and cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Clinical trials. Nail-biting time for trials of COX-2 drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Comparative cardiovascular safety of traditional nonsteroidal anti-inflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Protective effects of NSAIDs on the development of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Does NSAID use modify cognitive trajectories in the elderly? The Cache County study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Aspirin, NSAIDs, risk of dementia, and influence of the apolipoprotein E epsilon 4 allele in an elderly population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Postmortem studies of the effect of anti-inflammatory drugs on Alzheimer-type pathology and associated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Selective inhibition of Abeta42 production by NSAID R-enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Long-term efficacy and safety of celecoxib in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Substrate-targeting gamma-secretase modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Purification and characterization of the human gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Inflammatory mechanisms in Alzheimer's disease: implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Clinical trial of indomethacin in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

No effect of one-year treatment with indomethacin on Alzheimer's disease progression: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Randomized pilot study of nimesulide treatment in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

The role of the immune system in clearance of Abeta from the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Brain inflammation and adult neurogenesis: the dual role of microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

The potential role of non-steroidal anti-inflammatory drugs in treating Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

A novel phospholipid derivative of indomethacin, DP-155 [mixture of 1-steroyl and 1-palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl [corrected] choline], shows superior safety and simil

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Behavioural and histopathological analyses of ibuprofen treatment on the effect of aggregated Abeta(1-42) injections in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Dexibuprofen (S(+)-isomer ibuprofen) reduces microglial activation and impairments of spatial working memory induced by chronic lipopolysaccharide infusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Sulindac improves memory and increases NMDA receptor subunits in aged Fischer 344 rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

The effects of a novel NSAID on chronic neuroinflammation are age dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066780

10.1517/13543780903066780

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference