(Q37551939)

21 August 2017

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title

Interleukin-1 beta targeted therapy for type 2 diabetes (English)

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21 August 2017

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Desiree M Schumann

3

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Joachim Størling

object named as

Joachim Størling

series ordinal

4

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Kathrin Maedler

object named as

Kathrin Maedler

series ordinal

1

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author name string

Gitanjali Dharmadhikari

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

1 September 2009

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Expert Opinion on Biological Therapy

21 August 2017

published in

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21 August 2017

volume

9

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21 August 2017

issue

9

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21 August 2017

page(s)

1177-1188

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Nucleotide sequence of human monocyte interleukin 1 precursor cDNA

21 August 2017

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The interleukin-1 receptor family

21 January 2018

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Evidence for the presence of type I IL-1 receptors on beta-cells of islets of Langerhans

21 January 2018

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Human interleukin 1 induces interleukin 1 gene expression in human vascular smooth muscle cells

21 January 2018

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The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death

21 January 2018

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Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I.

21 January 2018

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NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice

21 January 2018

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Protein kinase Cdelta activation by interleukin-1beta stabilizes inducible nitric-oxide synthase mRNA in pancreatic beta-cells

21 January 2018

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Inhibition of protein kinase C delta protects rat INS-1 cells against interleukin-1beta and streptozotocin-induced apoptosis

21 January 2018

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Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-γ expression in splenic T cells

21 January 2018

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Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

21 January 2018

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Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

21 January 2018

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Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells

21 January 2018

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Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

21 January 2018

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Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases

21 January 2018

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Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans

21 January 2018

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Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

21 January 2018

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The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells.

21 January 2018

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Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.

21 January 2018

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Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets

21 January 2018

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Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity

21 January 2018

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Diabetes and suppressors of cytokine signaling proteins

21 January 2018

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Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

21 January 2018

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The cytokine IL-1beta transiently enhances P2X7 receptor expression and function in human astrocytes.

21 January 2018

1 reference

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IL-1 produced and released endogenously within human islets inhibits beta cell function

21 January 2018

1 reference

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Pancreatic beta-cell damage mediated by beta-cell production of interleukin-1. A novel mechanism for virus-induced diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

21 January 2018

1 reference

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Mechanisms of beta-cell death in type 2 diabetes.

21 January 2018

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Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

21 January 2018

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High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB.

21 January 2018

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Beta cell death in hyperglycaemic Psammomys obesus is not cytokine-mediated

21 January 2018

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Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

21 January 2018

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Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

21 January 2018

1 reference

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Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

21 January 2018

1 reference

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Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic beta-cell destruction in insulin-dependent diabetes mellitus

21 January 2018

1 reference

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Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus

21 January 2018

1 reference

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The Fas pathway is involved in pancreatic beta cell secretory function

21 January 2018

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Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets

21 January 2018

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Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

21 January 2018

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The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1.

21 January 2018

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Biological role of interleukin 1 receptor antagonist isoforms

21 January 2018

1 reference

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Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets

21 January 2018

1 reference

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Adenoviral overexpression of interleukin-1 receptor antagonist protein increases beta-cell replication in rat pancreatic islets

21 January 2018

1 reference

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Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation

21 January 2018

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Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly

21 January 2018

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Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome

21 January 2018

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The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia

21 January 2018

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Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Insulin sensitivity: modulation by nutrients and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Increased number of islet-associated macrophages in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Impaired glucose-stimulated insulin secretion is coupled with exocrine pancreatic lesions in the Cohen diabetic rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Critical nodes in signalling pathways: insights into insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Obesity is associated with macrophage accumulation in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Adipocytokines: leptin--the classical, resistin--the controversical, adiponectin--the promising, and more to come

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Adipocytokines: mediators linking adipose tissue, inflammation and immunity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712590903136688

Adipocytokines and the metabolic complications of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Making insulin-deficient type 1 diabetic rodents thrive without insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Differential roles of Mac-1+ cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

IKK-beta links inflammation to obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Interleukin-1 and neuronal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Potential mechanisms of interleukin-1 involvement in cerebral ischaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Interleukin 1 in the brain: biology, pathology and therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Molecular basis of fever in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: genetic, pharmacological and developmental aspects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

The role of endogenous interleukin-1 in stress-induced adrenal activation and adrenalectomy-induced adrenocorticotropic hormone hypersecretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

A neuromodulatory role of interleukin-1beta in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Interleukin-1 beta: a common cause of Alzheimer's disease and diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Plasma cytokines profile in older subjects with late onset Alzheimer's disease or vascular dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

JNK signalling: a possible target to prevent neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Neuronal PTP1B regulates body weight, adiposity and leptin action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Nuclear factor-kappaB regulates beta-cell death: a critical role for A20 in beta-cell protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Caspase-1 is not required for type 1 diabetes in the NOD mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

The anti-interleukin-1 in type 1 diabetes action trial--background and rationale

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

The c-Jun N-terminal kinase JNK participates in cytokine- and isolation stress-induced rat pancreatic islet apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Adenoviral overproduction of interleukin-1 receptor antagonist increases beta cell replication and mass in syngeneically transplanted islets, and improves metabolic outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

Inhibition of glucose-induced insulin secretion by long-term preexposure of pancreatic islets to leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712590903136688

10.1517/14712590903136688

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference