(Q37569003)

English

Saturation mutagenesis of selected residues of the α-peptide of the lantibiotic lacticin 3147 yields a derivative with enhanced antimicrobial activity

scientific article published on 25 February 2013

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24 February 2020

Saturation mutagenesis of selected residues of the α-peptide of the lantibiotic lacticin 3147 yields a derivative with enhanced antimicrobial activity (English)

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24 February 2020

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24 February 2020

Evelyn M Molloy

2

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24 February 2020

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24 February 2020

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24 February 2020

Reynolds Paul Ross

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24 February 2020

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Catalin Iancu

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24 February 2020

Lorraine A Draper

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24 February 2020

Paula M O' Connor

5

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24 February 2020

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25 February 2013

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24 February 2020

Microbial Biotechnology

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24 February 2020

6

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24 February 2020

5

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24 February 2020

564-575

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24 February 2020

Bioengineered nisin A derivatives with enhanced activity against both Gram positive and Gram negative pathogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Homologues and bioengineered derivatives of LtnJ vary in ability to form D-alanine in the lantibiotic lacticin 3147.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Studies with bioengineered Nisin peptides highlight the broad-spectrum potency of Nisin V.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Manipulation of charged residues within the two-peptide lantibiotic lacticin 3147.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13

1 reference

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23 August 2017

Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Dissecting structural and functional diversity of the lantibiotic mersacidin

1 reference

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23 August 2017

Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system

1 reference

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23 August 2017

Discovery of medically significant lantibiotics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Lantibiotics: mode of action, biosynthesis and bioengineering

1 reference

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23 August 2017

Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America

1 reference

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23 August 2017

Structure-activity relationship studies of the two-component lantibiotic haloduracin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Two-peptide lantibiotics: a medical perspective.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Bacteriocin-based strategies for food biopreservation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Lantibiotics: peptides of diverse structure and function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Relatedness between the two-component lantibiotics lacticin 3147 and staphylococcin C55 based on structure, genetics and biological activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Lipid II as a target for antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Posttranslational conversion of L-serines to D-alanines is vital for optimal production and activity of the lantibiotic lacticin 3147

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Bacteriocins: developing innate immunity for food

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Streptococcus rattus strain BHT produces both a class I two-component lantibiotic and a class II bacteriocin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Sequential actions of the two component peptides of the lantibiotic lacticin 3147 explain its antimicrobial activity at nanomolar concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Enterococcal cytolysin: a novel two component peptide system that serves as a bacterial defense against eukaryotic and prokaryotic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Bacterial lantibiotics: strategies to improve therapeutic potential.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

The structure of the antimicrobial peptide Ac-RRWWRF-NH2 bound to micelles and its interactions with phospholipid bilayers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Plantaricin W from Lactobacillus plantarum belongs to a new family of two-peptide lantibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Peptides on phage: a vast library of peptides for identifying ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

Searching for Peptide Ligands with an Epitope Library

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

23 August 2017

The dawning of a 'Golden era' in lantibiotic bioengineering.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

6 September 2017

Identification of genes encoding two-component lantibiotic production in Staphylococcus aureus C55 and other phage group II S. aureus strains and demonstration of an association with the exfoliative toxin B gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

6 September 2017

Structure-activity study of the lantibiotic mutacin II from Streptococcus mutans T8 by a gene replacement strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

14 September 2017

Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

14 September 2017

Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

14 September 2017

Construction of an expression system for site-directed mutagenesis of the lantibiotic mersacidin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

14 September 2017

Improvement of solubility and stability of the antimicrobial peptide nisin by protein engineering.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

14 September 2017

Protein engineering of lantibiotics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

28 September 2017

Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

25 June 2018

Bioengineered nisin derivatives with enhanced activity in complex matrices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

1 September 2018

Comparison of the activities of the lantibiotics nisin and lacticin 3147 against clinically significant mycobacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

1 September 2018

A comparison of the activities of lacticin 3147 and nisin against drug-resistant Staphylococcus aureus and Enterococcus species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

1 September 2018

Evaluation of essential and variable residues of nukacin ISK-1 by NNK scanning.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

1 September 2018

The generation of nisin variants with enhanced activity against specific gram-positive pathogens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

1 September 2018

Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

1 September 2018

Site-directed mutagenesis of the hinge region of nisinZ and properties of nisinZ mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

1 September 2018

In vivo conversion of L-serine to D-alanine in a ribosomally synthesized polypeptide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

1 September 2018

Enhancement of the chemical and antimicrobial properties of subtilin by site-directed mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918158

1 September 2018

Structure-activity relationships in the peptide antibiotic nisin: antibacterial activity of fragments of nisin

1 reference

https://api.crossref.org/works/10.1111%2F1751-7915.12041

21 January 2018

Engineering a disulfide bond and free thiols in the lantibiotic nisin Z

1 reference

https://pubmed.ncbi.nlm.nih.gov/23433070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of charge differences in the C-terminal part of nisin on antimicrobial activity and signaling capacity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23433070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mode of action of the lantibiotic lacticin 3147--a complex mechanism involving specific interaction of two peptides and the cell wall precursor lipid II

1 reference

https://pubmed.ncbi.nlm.nih.gov/23433070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel two-peptide lantibiotic, haloduracin, produced by the alkaliphile Bacillus halodurans C-125

1 reference

https://pubmed.ncbi.nlm.nih.gov/23433070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A system for the random mutagenesis of the two-peptide lantibiotic lacticin 3147: analysis of mutants producing reduced antibacterial activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/23433070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/1751-7915.12041

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23433070%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23433070%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23433070%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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