(Q37575518)

21 August 2017

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title

The effect of oral lipids and circulating lipoproteins on the metabolism of drugs (English)

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21 August 2017

Jigar P Patel

1

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21 August 2017

Dion R Brocks

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

1 November 2009

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Expert Opinion on Drug Metabolism & Toxicology

21 August 2017

published in

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21 August 2017

volume

5

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21 August 2017

issue

11

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21 August 2017

page(s)

1385-1398

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The evolving role of drug metabolism in drug discovery and development

21 August 2017

cites work

1 reference

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The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans

21 January 2018

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Cytochrome P450s and cholesterol homeostasis

21 January 2018

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The influence of lipids on stereoselective pharmacokinetics of halofantrine: Important implications in food-effect studies involving drugs that bind to lipoproteins

21 January 2018

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The effect of increased lipoprotein levels on the pharmacokinetics of cyclosporine A in the laboratory rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Pharmacokinetics of Amiodarone in hyperlipidemic and simulated high fat-meal rat models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Effects of intestinal constituents and lipids on intestinal formation and pharmacokinetics of desethylamiodarone formed from amiodarone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Lipid-based formulations for oral administration: opportunities for bioavailability enhancement and lipoprotein targeting of lipophilic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

From interaction of lipidic vehicles with intestinal epithelial cell membranes to the formation and secretion of chylomicrons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Lipophilicity in PK design: methyl, ethyl, futile

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903176439

Plasma lipoproteins: genetic influences and clinical implications

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903176439

Genetic determinants of plasma lipoproteins

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903176439

A controlled trial of the effects of pattern of alcohol intake on serum lipid levels in regular drinkers

21 January 2018

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Dyslipidemia and renal disease: pathogenesis and clinical consequences

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903176439

Uremia-specific alterations in lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Lipid metabolism in cognitive decline and dementia

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903176439

Cardiovascular risk and subclinical hypothyroidism: focus on lipids and new emerging risk factors. What is the evidence?

21 January 2018

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Altered lipid metabolism in brain injury and disorders

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903176439

Drug-Induced lipid changes: a review of the unintended effects of some commonly used drugs on serum lipid levels

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903176439

Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903176439

Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250903176439

Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk

21 January 2018

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The fatty acid transport function of fatty acid-binding proteins

21 January 2018

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An examination of the factors affecting intestinal lymphatic transport of dietary lipids

21 January 2018

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The small intestine as a xenobiotic-metabolizing organ

21 January 2018

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Enhancing drug absorption using lipids: a case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections

21 January 2018

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Effects of monoglycerides on P-glycoprotein: modulation of the activity and expression in Caco-2 cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Lipid-based formulations for danazol containing a digestible surfactant, Labrafil M2125CS: in vivo bioavailability and dynamic in vitro lipolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Pharmacokinetics of halofantrine in man: effects of food and dose size

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

An examination of the interplay between enterocyte-based metabolism and lymphatic drug transport in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Effect of dietary oil intake on hepatic cytochrome P450 activity in the rat.

21 January 2018

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The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes

21 January 2018

1 reference

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Intestinal cholesterol transport proteins: an update and beyond

21 January 2018

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Cholesterol interaction with the daunorubicin binding site of P-glycoprotein

21 January 2018

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Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin

21 January 2018

1 reference

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Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Prescribing amiodarone: an evidence-based review of clinical indications

21 January 2018

1 reference

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Bioavailability of amiodarone tablets administered with and without food in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Demonstration of docosahexaenoic acid as a bioavailability enhancer for CYP3A substrates: in vitro and in vivo evidence using cyclosporin in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Health benefits of docosahexaenoic acid (DHA)

21 January 2018

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Saquinavir. A review of its pharmacology and clinical potential in the management of HIV infection

21 January 2018

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High-fat meals increase the clearance of cyclosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration

21 January 2018

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Study of the pharmacokinetic interaction between simvastatin and prescription omega-3-acid ethyl esters

21 January 2018

1 reference

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Development and validation of a sensitive and rapid non-aqueous LC-ESI-MS/MS method for measurement of diosgenin in the plasma of normal and hyperlipidemic rats: a comparative study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Inhibitory effects of saturated and polyunsaturated fatty acids on the cytochrome P450 3A activity in rat liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Modulation of the levels of cytochromes P450 in rat liver and lung by dietary lipid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

n-6 and n-3 polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

The effect of experimental hyperlipidemia on the stereoselective tissue distribution, lipoprotein association and microsomal metabolism of (+/-)-halofantrine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

The stereoselective distribution of halofantrine enantiomers within human, dog, and rat plasma lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Pharmacokinetics of human immunodeficiency virus protease inhibitor, nelfinavir, in poloxamer 407-induced hyperlipidemic model rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Effect of a high-fat meal on absorption and disposition of lipophilic compounds: the importance of degree of association with triglyceride-rich lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

The mammalian low-density lipoprotein receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Functional activities of hepatic lipoprotein receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Strain differences in hepatic cytochrome P450 1A and 3A expression between Sprague-Dawley and Wistar rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Association of halofantrine with postprandially derived plasma lipoproteins decreases its clearance relative to administration in the fasted state

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Transport and metabolism of cyclosporine in isolated rat hepatocytes. The effects of lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Insights into the effects of hyperlipoproteinemia on cyclosporine A biodistribution and relationship to renal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903176439

10.1517/17425250903176439

21 January 2018

Identifiers

DOI

1 reference

release_2lbm5oz3hnfqxfhu4zmqbhiwem

21 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2lbm5oz3hnfqxfhu4zmqbhiwem

mapped directly with Wikidata item

24 November 2022

based on heuristic

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