(Q37578319)

21 August 2017

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title

Ectodomain shedding of the receptor for advanced glycation end products: a novel therapeutic target for Alzheimer's disease (English)

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21 August 2017

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3

Yingqun Wang

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21 August 2017

Ling Zhang

1

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21 August 2017

Rolf Postina

series ordinal

2

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21 August 2017

publication date

1 December 2009

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Cellular and Molecular Life Sciences

21 August 2017

published in

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21 August 2017

volume

66

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21 August 2017

issue

24

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21 August 2017

page(s)

3923-3935

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https://scigraph.springernature.com/pub.10.1007/s00018-009-0121-4

21 August 2017

exact match

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cites work

Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0121-4

Central role of RAGE-dependent neointimal expansion in arterial restenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0121-4

Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0121-4

Blockade of receptor for advanced glycation end-products restores effective wound healing in diabetic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0121-4

Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0121-4

Membrane protein secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0121-4

Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0121-4

Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ

21 January 2018

1 reference

12 December 2020

Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases

1 reference

12 December 2020

Plasma levels of soluble receptor for advanced glycation end products and coronary artery disease in nondiabetic men.

1 reference

12 December 2020

An essential role for ectodomain shedding in mammalian development

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12 December 2020

Yeast expression of the cytokine receptor domain of the soluble interleukin-6 receptor

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12 December 2020

Identification, classification, and expression of RAGE gene splice variants

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12 December 2020

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

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12 December 2020

Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia.

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12 December 2020

Calcium-regulated intramembrane proteolysis of the RAGE receptor

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12 December 2020

An oxidative stress mechanism mediates chelerythrine-induced heparin-binding EGF-like growth factor ectodomain shedding

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12 December 2020

A novel role of metalloproteinase in cancer-mediated immunosuppression.

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12 December 2020

Matrix metalloproteinases and bone

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12 December 2020

Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products

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12 December 2020

Shedding light on ADAM metalloproteinases

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12 December 2020

Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.

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12 December 2020

RAGE-Abeta interactions in the pathophysiology of Alzheimer's disease

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12 December 2020

Membrane localization of membrane type 5 matrix metalloproteinase by AMPA receptor binding protein and cleavage of cadherins.

1 reference

12 December 2020

Purification and characterization of mouse soluble receptor for advanced glycation end products (sRAGE)

1 reference

12 December 2020

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers

1 reference

12 December 2020

ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha

1 reference

12 December 2020

Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42

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12 December 2020

The blood-brain barrier in health and chronic neurodegenerative disorders

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12 December 2020

Receptors for advanced glycosylation endproducts in human brain: role in brain homeostasis

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12 December 2020

Alzheimer's disease: the amyloid cascade hypothesis

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12 December 2020

Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease

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12 December 2020

Splice variants of the receptor for advanced glycosylation end products (RAGE) in human brain

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12 December 2020

Bryostatin-1: pharmacology and therapeutic potential as a CNS drug.

1 reference

12 December 2020

Cloning and characterization of a naturally occurring soluble form of TGF-beta type I receptor.

1 reference

12 December 2020

Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption

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12 December 2020

Protein ectodomain shedding

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12 December 2020

The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity

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12 December 2020

Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment.

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12 December 2020

The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts

1 reference

12 December 2020

N -Glycans on the receptor for advanced glycation end products influence amphoterin binding and neurite outgrowth

1 reference

12 December 2020

RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation.

1 reference

12 December 2020

Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells

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12 December 2020

Soluble forms of RAGE in human diseases: clinical and therapeutical implications

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12 December 2020

A closer look at alpha-secretase

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12 December 2020

Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

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12 December 2020

Evaluation of rage isoforms, ligands, and signaling in the brain.

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12 December 2020

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

1 reference

12 December 2020

A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis

1 reference

12 December 2020

Decreased plasma levels of soluble receptor for advanced glycation end-products in patients with essential hypertension.

1 reference

12 December 2020

Recombinant advanced glycation end product receptor pharmacokinetics in normal and diabetic rats.

1 reference

12 December 2020

The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein

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12 December 2020

Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases

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12 December 2020

A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders

1 reference

12 December 2020

The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system

1 reference

12 December 2020

Hydrogen peroxide mediates amyloid beta protein toxicity

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12 December 2020

The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions

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12 December 2020

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

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12 December 2020

The role of matrix metalloproteinases in autoimmune damage to the central and peripheral nervous system

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12 December 2020

RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model.

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12 December 2020

A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts

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12 December 2020

ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx

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12 December 2020

Biological activity and clinical implications of the matrix metalloproteinases.

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12 December 2020

Identification of serum factor inducing ectodomain shedding of proHB-EGF and sStudies of noncleavable mutants of proHB-EGF.

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12 December 2020

Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17.

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12 December 2020

Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead

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12 December 2020

Activation of macrophages by Alzheimer beta amyloid peptide.

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12 December 2020

Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration

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12 December 2020

Clearing the brain's amyloid cobwebs

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12 December 2020

A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis

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12 December 2020

Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C

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12 December 2020

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

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12 December 2020

Antagonism of RAGE suppresses peripheral nerve regeneration

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12 December 2020

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis

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12 December 2020

Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control

1 reference

12 December 2020

Tempering the wrath of RAGE: an emerging therapeutic strategy against diabetic complications, neurodegeneration, and inflammation

1 reference

12 December 2020

What's the RAGE? The receptor for advanced glycation end products (RAGE) and the dark side of glucose

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12 December 2020

Down-regulation of the receptor for advanced glycation end-products (RAGE) supports non-small cell lung carcinoma

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

Metabolic regulation of brain Abeta by neprilysin.

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12 December 2020

Proteolytic remodeling of extracellular matrix

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12 December 2020

Regulated proteolysis of RAGE and AbetaPP as possible link between type 2 diabetes mellitus and Alzheimer's disease

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12 December 2020

Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer.

1 reference

12 December 2020

The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein

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12 December 2020

Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease.

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12 December 2020

Expression of the receptor for advanced glycation end products in oligodendrocytes in response to oxidative stress

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12 December 2020

Matrix metalloproteinases and their endogenous inhibitors in neuronal physiology of the adult brain

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12 December 2020

Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer

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12 December 2020

IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways

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12 December 2020

Calcium-induced ERK activation in human T lymphocytes occurs via p56(Lck) and CaM-kinase.

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12 December 2020

Receptor for advanced glycation end products (RAGE) signaling induces CREB-dependent chromogranin expression during neuronal differentiation

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12 December 2020

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins

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12 December 2020

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

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12 December 2020

Advanced glycation endproducts stimulate the MAP-kinase pathway in tubulus cell line LLC-PK1.

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12 December 2020

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

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12 December 2020

Understanding RAGE, the receptor for advanced glycation end products

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12 December 2020

Activity of alpha-secretase as the common final effector of protein kinase C-dependent and -independent modulation of amyloid precursor protein metabolism

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12 December 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

12 December 2020

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

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12 December 2020

Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta.

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12 December 2020

Clearing amyloid through the blood-brain barrier

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12 December 2020

Constitutive and induced CD44 shedding by ADAM-like proteases and membrane-type 1 matrix metalloproteinase.

1 reference

12 December 2020

Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells

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12 December 2020

Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease

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12 December 2020

Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins

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12 December 2020

[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients

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12 December 2020

Can blood-brain barrier play a role in the development of cerebral amyloidosis and Alzheimer's disease pathology.

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12 December 2020

RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

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12 December 2020

The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease

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12 December 2020

The ADAM metalloproteinases

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12 December 2020

Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity.

1 reference

12 December 2020

Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).

1 reference

12 December 2020

Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts

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12 December 2020

A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)

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12 December 2020

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

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12 December 2020

Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3

1 reference

12 December 2020

10.1007/S00018-009-0121-4

Identifiers

DOI

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21 August 2017

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