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MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.
scientific article published on 17 January 2017
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Europe PubMed Central
PMC publication ID
5241118
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28095293%20AND%20SRC:MED&resulttype=core&format=json
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10 April 2020
title
MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2
(English)
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PMC publication ID
5241118
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28095293%20AND%20SRC:MED&resulttype=core&format=json
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10 April 2020
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Lauren J Walker
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1
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Europe PubMed Central
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5241118
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10 April 2020
Yo Sasaki
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3
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PMC publication ID
5241118
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28095293%20AND%20SRC:MED&resulttype=core&format=json
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10 April 2020
Jeffrey Milbrandt
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5
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5241118
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10 April 2020
Aaron DiAntonio
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6
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10 April 2020
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Daniel W Summers
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2
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5241118
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28095293%20AND%20SRC:MED&resulttype=core&format=json
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10 April 2020
E J Brace
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4
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5241118
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10 April 2020
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17 January 2017
1 reference
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5241118
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retrieved
10 April 2020
published in
eLife
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5241118
reference URL
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10 April 2020
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6
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Europe PubMed Central
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retrieved
10 April 2020
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NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
retrieved
23 August 2017
Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
SARM1 activation triggers axon degeneration locally via NAD⁺ destruction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
retrieved
23 August 2017
Absence of SARM1 rescues development and survival of NMNAT2-deficient axons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
retrieved
23 August 2017
Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
CRISPR-Cas9 knockin mice for genome editing and cancer modeling
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
retrieved
23 August 2017
Sarm1-mediated axon degeneration requires both SAM and TIR interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
retrieved
23 August 2017
Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
retrieved
23 August 2017
The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
retrieved
23 August 2017
SCG10 is a JNK target in the axonal degeneration pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
A conditioning lesion protects axons from degeneration via the Wallenda/DLK MAP kinase signaling cascade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
Axon degeneration: Molecular mechanisms of a self-destruction pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis
1 reference
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PubMed Central
reference URL
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23 August 2017
Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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23 August 2017
Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5241118
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Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade
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PubMed Central
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Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity
1 reference
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PubMed Central
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A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling.
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PubMed Central
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Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
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PubMed Central
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PubMed Central
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Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism
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PubMed Central
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PubMed Central
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1 reference
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PubMed Central
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1 reference
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PubMed Central
reference URL
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1 reference
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PubMed Central
reference URL
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Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.
1 reference
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1 reference
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1 September 2018
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1 reference
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PubMed Central
reference URL
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retrieved
1 September 2018
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1 reference
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1 September 2018
wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila
1 reference
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PubMed Central
reference URL
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retrieved
1 September 2018
Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye.
1 reference
stated in
PubMed Central
reference URL
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retrieved
1 September 2018
Identifiers
DOI
10.7554/ELIFE.22540
1 reference
stated in
Europe PubMed Central
PMC publication ID
5241118
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28095293%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
PMC publication ID
5241118
1 reference
stated in
Europe PubMed Central
PMC publication ID
5241118
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28095293%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
PubMed publication ID
28095293
1 reference
stated in
Europe PubMed Central
PMC publication ID
5241118
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28095293%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
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