(Q37600068)

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Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer

scientific article published on 08 July 2016

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scholarly article

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18 March 2020

Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer (English)

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18 March 2020

pancreatic cancer

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Gregory L Beatty

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18 March 2020

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Yaqing Zhang

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18 March 2020

Ashley Velez-Delgado

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18 March 2020

Esha Mathew

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18 March 2020

Dongjun Li

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18 March 2020

Flor M Mendez

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18 March 2020

Kevin Flannagan

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18 March 2020

Andrew D Rhim

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18 March 2020

Diane M Simeone

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18 March 2020

Marina Pasca di Magliano

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18 March 2020

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8 July 2016

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18 March 2020

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18 March 2020

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18 March 2020

1

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18 March 2020

124-136

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18 March 2020

From bench to bedside a comprehensive review of pancreatic cancer immunotherapy

1 reference

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Characterization of myeloid leukocytes and soluble mediators in pancreatic cancer: importance of myeloid-derived suppressor cells.

1 reference

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Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma

1 reference

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23 August 2017

Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma

1 reference

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23 August 2017

Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions

1 reference

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CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.

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23 August 2017

Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia

1 reference

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23 August 2017

Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity.

1 reference

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23 August 2017

MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice

1 reference

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23 August 2017

Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance

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Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs.

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Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma

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Metastatic pancreatic cancer is dependent on oncogenic Kras in mice

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Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses

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23 August 2017

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma

1 reference

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23 August 2017

EGF receptor is required for KRAS-induced pancreatic tumorigenesis

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23 August 2017

Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia

1 reference

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23 August 2017

Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.

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23 August 2017

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

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23 August 2017

A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma.

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Ras history: The saga continues

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23 August 2017

Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.

1 reference

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CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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12 December 2020

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1 reference

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inferred from PubMed ID database lookup

Identifiers

10.1136/GUTJNL-2016-312078

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27402485%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27402485%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27402485%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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