(Q37618653)

21 August 2017

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title

The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures (English)

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21 August 2017

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Erik De Clercq

1

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language of work or name

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1 January 2011

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Medicinal Research Reviews

21 August 2017

published in

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21 August 2017

volume

31

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21 August 2017

issue

1

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21 August 2017

page(s)

118-160

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Broad-spectrum antiviral activity and mechanism of antiviral action of the fluoroquinolone derivative K-12.

21 August 2017

cites work

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Reduced sensitivity of influenza A (H5N1) to oseltamivir

21 January 2018

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Efficient synthesis of highly active phospha-isosteres of the influenza neuraminidase inhibitor oseltamivir

21 January 2018

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Association between respiratory syncytial virus outbreaks and lower respiratory tract deaths of infants and young children

21 January 2018

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Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis

21 January 2018

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Synthesis, and cytotoxic activity of N(ind)-alkoxy derivatives of antibiotic arcyriarubin and dechloro-rebeccamycin aglycon

21 January 2018

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21 January 2018

12 December 2020

Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants

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12 December 2020

Respiratory syncytial virus escape mutant derived in vitro resists palivizumab prophylaxis in cotton rats

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12 December 2020

Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings

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12 December 2020

In vivo selection of respiratory syncytial viruses resistant to palivizumab

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12 December 2020

Isolation and transmission of human retrovirus (human t-cell leukemia virus).

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12 December 2020

Synthesis and mode of action of hydrophobic derivatives of the glycopeptide antibiotic eremomycin and des-(N-methyl-D-leucyl)eremomycin against glycopeptide-sensitive and -resistant bacteria

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12 December 2020

Antiherpesvirus activities of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine (A-5021) in cell culture

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12 December 2020

D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75.

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12 December 2020

Chemical modification of antibiotic streptonigrin; synthesis and properties of 2'-decarboxy-2'-aminostreptonigrin (streptonigrone-2'-imine).

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12 December 2020

Human infection with highly pathogenic avian influenza virus (H5N1) in northern Vietnam, 2004-2005.

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12 December 2020

Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1.

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12 December 2020

Aurintricarboxylic acid inhibits the early stage of vaccinia virus replication by targeting both cellular and viral factors

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12 December 2020

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

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12 December 2020

Probable limited person-to-person transmission of highly pathogenic avian influenza A (H5N1) virus in China

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12 December 2020

Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations

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12 December 2020

Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma

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12 December 2020

Modification of the antibiotic olivomycin I at the 2'-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity

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12 December 2020

Design, synthesis, and enzymatic evaluation of multisubstrate analogue inhibitors of Escherichia coli thymidine phosphorylase

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12 December 2020

Influenza A H5N1 clade 2.3.4 virus with a different antiviral susceptibility profile replaced clade 1 virus in humans in northern Vietnam

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12 December 2020

Synthesis of alkenyldiarylmethane (ADAM) non-nucleoside HIV-1 reverse transcriptase inhibitors with non-identical aromatic rings

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12 December 2020

Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection

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12 December 2020

Inhibition of respiratory syncytial virus of subgroups A and B using deoxyribozyme DZ1133 in mice

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12 December 2020

Screening for antiviral inhibitors of the HIV integrase-LEDGF/p75 interaction using the AlphaScreen luminescent proximity assay

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12 December 2020

Novel targets for HIV therapy

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12 December 2020

Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene

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12 December 2020

Improvement of progressive multifocal leukoencephalopathy after cidofovir therapy in a patient with a destructive polyarthritis

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12 December 2020

New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action

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12 December 2020

Detection of human influenza A (H1N1) and B strains with reduced sensitivity to neuraminidase inhibitors.

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12 December 2020

Design, synthesis, anti-HIV activities, and metabolic stabilities of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors

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12 December 2020

Mono and double modified teicoplanin aglycon derivatives on the amino acid no. 7; structure-activity relationship

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12 December 2020

Antiviral oseltamivir is not removed or degraded in normal sewage water treatment: implications for development of resistance by influenza A virus

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12 December 2020

Respiratory syncytial virus: recent progress towards the discovery of effective prophylactic and therapeutic agents

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12 December 2020

New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors

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12 December 2020

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

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12 December 2020

Thymidine phosphorylase activity associated with platelet-derived endothelial cell growth factor

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12 December 2020

A role for LEDGF/p75 in targeting HIV DNA integration

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12 December 2020

Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics

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12 December 2020

Inhibition of thymidine phosphorylase by 6-aminothymine and derivatives of 6-aminouracil

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12 December 2020

Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds

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12 December 2020

Avian influenza A (H5N1) infection in eastern Turkey in 2006.

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12 December 2020

High-level expression of active HIV-1 integrase from a synthetic gene in human cells

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12 December 2020

Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction

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12 December 2020

Aurintricarboxylic acid protects against cell death caused by lipopolysaccharide in macrophages by decreasing inducible nitric-oxide synthase induction via IkappaB kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kina

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12 December 2020

Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro.

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12 December 2020

Antiviral efficacy of VP14637 against respiratory syncytial virus in vitro and in cotton rats following delivery by small droplet aerosol

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12 December 2020

Oseltamivir-resistant influenza a viruses circulating in Japan

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12 December 2020

Inhibition of Respiratory Syncytial Virus Fusion by the Small Molecule VP-14637 via Specific Interactions with F Protein

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12 December 2020

Inhibition of tubulin polymerization by select alkenyldiarylmethanes

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12 December 2020

Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice.

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12 December 2020

Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus

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12 December 2020

Activity of the neuraminidase inhibitor A-315675 against oseltamivir-resistant influenza neuraminidases of N1 and N2 subtypes

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12 December 2020

Widespread oseltamivir resistance in influenza A viruses (H1N1), South Africa

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12 December 2020

A new type of chemical modification of glycopeptides antibiotics: aminomethylated derivatives of eremomycin and their antibacterial activity

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12 December 2020

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

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12 December 2020

Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid

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12 December 2020

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

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12 December 2020

Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: randomized, controlled trials for prophylaxis and treatment.

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12 December 2020

Synthesis and biological activity of derivatives of glycopeptide antibiotics eremomycin and vancomycin nitrosated, acylated or carbamoylated at the N-terminal

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12 December 2020

Efficacy of oral ribavirin in lung transplant patients with respiratory syncytial virus lower respiratory tract infection

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12 December 2020

Fatal oseltamivir-resistant influenza virus infection

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12 December 2020

Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections

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12 December 2020

Activation of the insulin-like growth factor 1 signaling pathway by the antiapoptotic agents aurintricarboxylic acid and evans blue

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12 December 2020

Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59).

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12 December 2020

Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection

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12 December 2020

Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

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12 December 2020

Inhibition of respiratory syncytial virus in cultured cells by nucleocapsid gene targeted deoxyribozyme (DNAzyme).

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12 December 2020

Orally active fusion inhibitor of respiratory syncytial virus

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12 December 2020

Intravesical instillation of cidofovir in the treatment of hemorrhagic cystitis caused by adenovirus type 11 in a bone marrow transplant recipient

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12 December 2020

Novel 6-substituted uracil analogs as inhibitors of the angiogenic actions of thymidine phosphorylase

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12 December 2020

Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines

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12 December 2020

1,N2-Ethenoguanine and N2,3-ethenoguanine. Synthesis and comparison of the electronic spectral properties of these linear and angular triheterocycles related to the Y bases

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12 December 2020

Respiratory syncytial virus infection in adults

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12 December 2020

Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents

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12 December 2020

Synthesis and biological activity of tricyclic analogues of 9-[[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine

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12 December 2020

Cidofovir bladder instillation for the treatment of BK hemorrhagic cystitis after allogeneic stem cell transplantation

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12 December 2020

Natural variation can significantly alter the sensitivity of influenza A (H5N1) viruses to oseltamivir.

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12 December 2020

BK virus nephropathy in renal transplant patients in London.

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12 December 2020

Synthesis and antiviral activity of 3-substituted derivatives of 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purines, tricyclic analogs of acyclovir and ganciclovir

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12 December 2020

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

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12 December 2020

Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors

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12 December 2020

Integrase, LEDGF/p75 and HIV replication

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12 December 2020

Progressive multifocal leukoencephalopathy in a non-AIDS patient: high efficiency of combined cytarabine and cidofovir

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12 December 2020

Neuraminidase inhibitor-resistant recombinant A/Vietnam/1203/04 (H5N1) influenza viruses retain their replication efficiency and pathogenicity in vitro and in vivo.

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12 December 2020

Respiratory syncytial virus infections: recent prospects for control

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12 December 2020

Antivirals for the treatment of polyomavirus BK replication

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12 December 2020

Synthesis of a non-nucleoside reverse transcriptase inhibitor in the alkenyldiarylmethane (ADAM) series with optimized potency and therapeutic index

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12 December 2020

Efficacy of oseltamivir therapy in ferrets inoculated with different clades of H5N1 influenza virus

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12 December 2020

Adjuvant low-dose cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients.

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12 December 2020

Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract

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12 December 2020

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

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12 December 2020

Palivizumab prophylaxis, respiratory syncytial virus, and subsequent recurrent wheezing

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12 December 2020

Purification and properties of an endothelial cell growth factor from human platelets

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12 December 2020

Anti-influenza virus agents: synthesis and mode of action

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12 December 2020

Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity

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12 December 2020

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

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12 December 2020

Three Indonesian clusters of H5N1 virus infection in 2005

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12 December 2020

Synthesis and antiviral activity of novel acyclic nucleosides: discovery of a cyclopropyl nucleoside with potent inhibitory activity against herpesviruses

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12 December 2020

Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives

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12 December 2020

Perspectives for the chemotherapy of respiratory syncytial virus (RSV) infections

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12 December 2020

Synthesis of hydrophobic N'-mono and N',N"-double alkylated eremomycins inhibiting the transglycosylation stage of bacterial cell wall biosynthesis.

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12 December 2020

In search of small molecules blocking interactions between HIV proteins and intracellular cofactors

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12 December 2020

Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.

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12 December 2020

Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets

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12 December 2020

Characterization of a replication-competent, integrase-defective human immunodeficiency virus (HIV)/simian virus 40 chimera as a powerful tool for the discovery and validation of HIV integrase inhibitors

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12 December 2020

Structure-activity relationship studies of a series of antiviral and antibacterial aglycon derivatives of the glycopeptide antibiotics vancomycin, eremomycin, and dechloroeremomycin

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12 December 2020

Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection

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12 December 2020

Synthesis and cytotoxic properties of 4,11-bis[(aminoethyl)amino]anthra[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones

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12 December 2020

Low-dose cidofovir treatment of BK virus-associated hemorrhagic cystitis in recipients of hematopoietic stem cell transplant

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12 December 2020

The discovery of antiviral agents: ten different compounds, ten different stories

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12 December 2020

Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity.

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12 December 2020

A novel neuraminidase deletion mutation conferring resistance to oseltamivir in clinical influenza A/H3N2 virus

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12 December 2020

Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient

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12 December 2020

Characterization of drug-resistant recombinant influenza A/H1N1 viruses selected in vitro with peramivir and zanamivir

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12 December 2020

Inhibition of respiratory viruses by nasally administered siRNA.

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12 December 2020

The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors

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12 December 2020

Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues.

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12 December 2020

Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds

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12 December 2020

An essential role for LEDGF/p75 in HIV integration

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12 December 2020

Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors

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12 December 2020

Synthesis and antiviral activity of novel N-substituted derivatives of acyclovir

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12 December 2020

Oseltamivir prophylactic regimens prevent H5N1 influenza morbidity and mortality in a ferret model

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12 December 2020

Raltegravir with optimized background therapy for resistant HIV-1 infection

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12 December 2020

Thymidine phosphorylase is angiogenic and promotes tumor growth.

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12 December 2020

Comparative activities of oseltamivir and A-322278 in immunocompetent and immunocompromised murine models of influenza virus infection

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12 December 2020

Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir

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12 December 2020

Fuchsin acid selectively inhibits human immunodeficiency virus (HIV) replication in vitro

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12 December 2020

Fundamental structure-activity relationships associated with a new structural class of respiratory syncytial virus inhibitor

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12 December 2020

Carboxamides and hydrazide of glycopeptide antibiotic eremomycin. Synthesis and antibacterial activity

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12 December 2020

Angiogenic activity of enzymes.

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12 December 2020

Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2'-deoxyribonucleosides

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12 December 2020

Current and future antiviral therapy of severe seasonal and avian influenza

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12 December 2020

The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action

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12 December 2020

Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo

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12 December 2020

Emergence of resistance to oseltamivir among influenza A(H1N1) viruses in Europe

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12 December 2020

Cidofovir in combination with HAART and survival in AIDS-associated progressive multifocal leukoencephalopathy

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12 December 2020

Human immunodeficiency virus type 1 (HIV-1) integration: a potential target for microbicides to prevent cell-free or cell-associated HIV-1 infection

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12 December 2020

Acyclic nucleoside phosphonates: a key class of antiviral drugs

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12 December 2020

Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice

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12 December 2020

Update on avian influenza A (H5N1) virus infection in humans

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12 December 2020

Aurintricarboxylic acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus

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12 December 2020

Oseltamivir-resistant influenza A viruses are transmitted efficiently among guinea pigs by direct contact but not by aerosol.

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12 December 2020

Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition

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12 December 2020

The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors

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12 December 2020

Anti-angiogenic activity of a novel multi-substrate analogue inhibitor of thymidine phosphorylase

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12 December 2020

The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo.

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12 December 2020

1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate

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12 December 2020

Developing new antiviral agents for influenza treatment: what does the future hold?

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12 December 2020

Oseltamivir-resistant influenza viruses A (H1N1), Norway, 2007-08

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12 December 2020

1,4-Benzodiazepines as inhibitors of respiratory syncytial virus

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12 December 2020

Phosphonomethoxyalkyl Analogs of Nucleotides

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12 December 2020

Effects of double combinations of amantadine, oseltamivir, and ribavirin on influenza A (H5N1) virus infections in cell culture and in mice

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12 December 2020

Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. The Respiratory Syncytial Virus Immune Globulin Study Group

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12 December 2020

Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States

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12 December 2020

Triphenylmethane dyes as inhibitors of reverse transcriptase, ribonucleic acid polymerase, and protein synthesis. Structure-activity relations

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12 December 2020

Cidofovir inhibits polyomavirus BK replication in human renal tubular cells downstream of viral early gene expression

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12 December 2020

Activities of various compounds against murine and primate polyomaviruses

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12 December 2020

Structural analysis of inhibition mechanisms of aurintricarboxylic acid on SARS-CoV polymerase and other proteins

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12 December 2020

RSV604, a novel inhibitor of respiratory syncytial virus replication

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12 December 2020

Modification of glycopeptide antibiotic eremomycin by the action of alkyl halides and study on antibacterial activity of the compounds obtained

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12 December 2020

Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study

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12 December 2020

Differential intracellular compartmentalization of herpetic thymidine kinases (TKs) in TK gene-transfected tumor cells: molecular characterization of the nuclear localization signal of herpes simplex virus type 1 TK.

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12 December 2020

Aurintricarboxylic acid is a nonspecific enzyme inhibitor

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12 December 2020

7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase

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12 December 2020

Activity of the oral neuraminidase inhibitor A-322278 against the oseltamivir-resistant H274Y (A/H1N1) influenza virus mutant in mice

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12 December 2020

High-yielding synthesis of the anti-influenza neuramidase inhibitor (-)-oseltamivir by three "one-pot" operations

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12 December 2020

Solid-phase synthesis of the alkenyldiarylmethane (ADAM) series of non-nucleoside HIV-1 reverse transcriptase inhibitors

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12 December 2020

A practical synthesis of (-)-oseltamivir

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12 December 2020

Tamiflu: the supply problem

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12 December 2020

Yet another ten stories on antiviral drug discovery (part D): paradigms, paradoxes, and paraductions

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12 December 2020

Antiviral agents active against influenza A viruses.

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12 December 2020

Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety.

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12 December 2020

Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors

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12 December 2020

Short duration aerosols of JNJ 2408068 (R170591) administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection

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12 December 2020

Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naive and treatment-experienced patients

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12 December 2020

Morbidity and mortality associated with nosocomial transmission of oseltamivir-resistant influenza A(H1N1) virus

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12 December 2020

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro

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12 December 2020

Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase.

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12 December 2020

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV).

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12 December 2020

Novel modifications in the alkenyldiarylmethane (ADAM) series of non-nucleoside reverse transcriptase inhibitors

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12 December 2020

Palivizumab: a review of its use as prophylaxis for serious respiratory syncytial virus infection

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12 December 2020

The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue.

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12 December 2020

Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus.

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12 December 2020

Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

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12 December 2020

Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137.

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12 December 2020

Angiogenesis: regulators and clinical applications

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12 December 2020

Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems

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12 December 2020

Comparing two integrase inhibitors. The first head-to-head study comparing raltegravir and elvitegravir

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12 December 2020

Effect of palivizumab prophylaxis in decreasing respiratory syncytial virus hospitalizations in premature infants

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12 December 2020

Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues

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12 December 2020

Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor

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12 December 2020

Inhibition of influenza virus by triphenylmethane compounds

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12 December 2020

Amides of antibiotic streptonigrin and amino dicarboxylic acids or aminosugars. Synthesis and biological evaluation

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12 December 2020

Mode of action of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl) cycloprop-1'-yl]methyl]guanine (A-5021) against herpes simplex virus type 1 and type 2 and varicella-zoster virus.

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12 December 2020

Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1)

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12 December 2020

Neuraminidase inhibitor-resistant and -sensitive influenza B viruses isolated from an untreated human patient

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12 December 2020

In search of a small-molecule inhibitor for respiratory syncytial virus

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12 December 2020

Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailability

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12 December 2020

Synthesis and antiviral activity of novel anti-VZV 5-substituted uracil nucleosides with a cyclopropane sugar moiety

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12 December 2020

Identification of bisindolylmaleimides and indolocarbazoles as inhibitors of HCV replication by tube-capture-RT-PCR.

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12 December 2020

HIV integrase inhibitors--out of the pipeline and into the clinic

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12 December 2020

Modifications on the heterocyclic base of acyclovir: syntheses and antiviral properties

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12 December 2020

Factors associated with case fatality of human H5N1 virus infections in Indonesia: a case series

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12 December 2020

Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors

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12 December 2020

Fractionation and structural elucidation of the active components of aurintricarboxylic acid, a potent inhibitor of protein nucleic acid interactions

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12 December 2020

Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms

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12 December 2020

Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors

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12 December 2020

Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)

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12 December 2020

Antiviral drug discovery: ten more compounds, and ten more stories (part B).

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12 December 2020

Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques

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12 December 2020

Neuraminidase inhibitor resistance after oseltamivir treatment of acute influenza A and B in children

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12 December 2020

Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant

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12 December 2020

CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity

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12 December 2020

Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics

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12 December 2020

Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV.

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12 December 2020

Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.

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12 December 2020

Inhibition of cytokine-induced JAK-STAT signalling pathways by an endonuclease inhibitor aurintricarboxylic acid

1 reference

12 December 2020

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Identifiers

DOI

10.1002/MED.20179

1 reference

21 August 2017

0 references

1 reference