(Q37621745)

21 August 2017

Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis (English)

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21 August 2017

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1

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21 August 2017

Charles C. Richardson

5

object named as

Charles C Richardson

1 reference

21 August 2017

Ying Li

2

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21 August 2017

Donald Johnson

3

1 reference

21 August 2017

Leonid Dzantiev

4

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21 August 2017

Louis J Romano

6

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21 August 2017

Tom Ellenberger

7

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21 August 2017

language of work or name

English

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publication date

4 November 2004

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Proceedings of the National Academy of Sciences of the United States of America

21 August 2017

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21 August 2017

101

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21 August 2017

46

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21 August 2017

16186-16191

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Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.

21 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Intrinsic conformational energetics associated with the glycosyl torsion in DNA: a quantum mechanical study

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Nutrition and dietary carcinogens

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

An open and closed case for all polymerases.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Rapid automated molecular replacement by evolutionary search

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Coding and conformational properties of oligonucleotides modified with the carcinogen N-2-acetylaminofluorene

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

The 'A rule' of mutagen specificity: a consequence of DNA polymerase bypass of non-instructional lesions?

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Mechanistic insights into replication across from bulky DNA adducts: a mutant polymerase I allows an N-acetyl-2-aminofluorene adduct to be accommodated during DNA synthesis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Interaction of Escherichia coli DNA polymerase I (Klenow fragment) with primer-templates containing N-acetyl-2-aminofluorene or N-2-aminofluorene adducts in the active site

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

On the mechanism of frameshift (deletion) mutagenesis in vitro.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

DNA binding and mutation spectra of the carcinogen N-2-aminofluorene in Escherichia coli. A correlation between the conformation of the premutagenic lesion and the mutation specificity.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

An optical study of the conformation of the aminofluorene-DNA complex.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Comparison of mutagenesis induced in single- and double-stranded M13 viral DNA by treatment with N-hydroxy-2-aminofluorene

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Isolation and characterization of oligodeoxynucleotides containing dG-N2-AAF and oxidation products of dG-C8-AF.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Role of DNA polymerase 3'----5' exonuclease activity in the bypass of aminofluorene lesions in DNA.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Fifty years of research on N-acetyl-2-aminofluorene, one of the most versatile compounds in experimental cancer research.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=528967

Single-base deletion induced by benzo[a]pyrene diol epoxide at the adenine phosphoribosyltransferase locus in human fibrosarcoma cell lines

25 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406516101

Carcinogen-induced mutation spectrum in wild-type, uvrA and umuC strains of Escherichia coli. Strain specificity and mutation-prone sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406516101

Mutagenic events in Escherichia coli and mammalian cells generated in response to acetylaminofluorene-derived DNA adducts positioned in the Nar I restriction enzyme site

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406516101

NMR structural studies of a 15-mer DNA duplex from a ras protooncogene modified with the carcinogen 2-aminofluorene: conformational heterogeneity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406516101

Solution structure of the aminofluorene [AF]-external conformer of the anti-[AF]-C8-dG adduct opposite dC in a DNA duplex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406516101

Solution structure of the aminofluorene [AF]-intercalated conformer of the syn-[AF]-C8-dG adduct opposite dC in a DNA duplex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406516101

Use of single-turnover kinetics to study bulky adduct bypass by T7 DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406516101

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406516101

Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406516101

Hot spots of frameshift mutations induced by the ultimate carcinogen N- acetoxy-N-2-acetylaminofluorene

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406516101

Differential effects of N-acetyl-2-aminofluorene and N-2-aminofluorene adducts on the conformational change in the structure of DNA polymerase I (Klenow fragment)

21 January 2018

1 reference

12 December 2020

Changes of stability and conformation of DNA following the covalent binding of a carcinogen

1 reference

12 December 2020

Strong sequence-dependent polymorphism in adduct-induced DNA structure: analysis of single N-2-acetylaminofluorene residues bound within the NarI mutation hot spot

1 reference

12 December 2020

Energy minimized structures of carcinogen-DNA adducts: 2-acetylaminofluorene and 2-aminofluorene

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12 December 2020

Force field conformational analysis of aminofluorene and acetylaminofluorene substituted deoxyguanosine

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12 December 2020

N-2-aminofluorene and N-2 acetylaminofluorene adducts: the local sequence context of an adduct and its chemical structure determine its replication properties

1 reference

12 December 2020

Structural characterization of two interchangeable conformations of a 2-aminofluorene-modified DNA oligomer by NMR and energy minimization

1 reference

12 December 2020

Mutagenesis at a site-specifically modified NarI sequence by acetylated and deacetylated aminofluorene adducts

1 reference

12 December 2020

Structural characterization of an N-acetyl-2-aminofluorene (AAF) modified DNA oligomer by NMR, energy minimization, and molecular dynamics

1 reference

12 December 2020

Mechanisms of frameshift mutations: insight from aromatic amines

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12 December 2020

Molecular mechanisms of mutagenesis by aromatic amines and amides

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12 December 2020

A single N-2-acetylaminofluorene adduct alters the footprint of T7 (exo-) DNA polymerase bound to a model primer-template junction

1 reference

12 December 2020

Nuclear magnetic resonance solution structures of covalent aromatic amine-DNA adducts and their mutagenic relevance

1 reference

12 December 2020

The mechanism of action of T7 DNA polymerase

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0406516101

1 reference

21 August 2017

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1 reference

21 August 2017

PubMed publication ID

15528277

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