(Q37623440)

21 August 2017

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title

Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways (English)

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21 August 2017

W-L Zhao

1

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PubMed ID

19865108

21 August 2017

language of work or name

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29 October 2009

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21 August 2017

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21 August 2017

24

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21 August 2017

1

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21 August 2017

13-21

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https://scigraph.springernature.com/pub.10.1038/leu.2009.223

21 August 2017

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Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease

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Critical roles of the PI3K/Akt signaling pathway in T cell development

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

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PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

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Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

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Human T-cell leukemia virus type I tax down-regulates the expression of phosphatidylinositol 3,4,5-trisphosphate inositol phosphatases via the NF-kappaB pathway

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Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.

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7 January 2021

The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation

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Phosphatidylinositol-3-phosphate kinase pathway activation protects leukemic large granular lymphocytes from undergoing homeostatic apoptosis

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7 January 2021

IL-2- and IL-15-induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes.

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Antiproliferative effect of rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition

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7 January 2021

Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells

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7 January 2021

Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.

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7 January 2021

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance

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7 January 2021

mTOR and cancer therapy

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Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises

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7 January 2021

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

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7 January 2021

Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia

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7 January 2021

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

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Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways

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7 January 2021

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Resveratrol-induced apoptosis in human T-cell acute lymphoblastic leukaemia MOLT-4 cells

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Curcumin induces apoptosis via inhibition of PI3'-kinase/AKT pathway in acute T cell leukemias

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7 January 2021

Notch regulation of lymphocyte development and function.

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7 January 2021

Notch signaling in leukemia

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7 January 2021

CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Defective expression of Notch1 and Notch2 in connection to alterations of c-Myc and Ikaros in gamma-radiation-induced mouse thymic lymphomas.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Potential involvement of Notch1 signalling in the pathogenesis of primary cutaneous CD30-positive lymphoproliferative disorders

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7 January 2021

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo.

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7 January 2021

The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

JAK-STAT signaling: from interferons to cytokines

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7 January 2021

Mining for JAK-STAT mutations in cancer

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7 January 2021

New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation

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7 January 2021

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

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7 January 2021

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia

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7 January 2021

A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Recurrent numerical aberrations of JAK2 and deregulation of the JAK2-STAT cascade in lymphomas

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Gene expression profiling identifies molecular subgroups among nodal peripheral T-cell lymphomas.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Pathophysiology defined by altered signal transduction pathways: the role of JAK-STAT and PI3K signaling in leukemic large granular lymphocytes.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

NF-kappaB in cancer: from innocent bystander to major culprit

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Inefficient ZAP-70 phosphorylation and decreased thymic selection in vivo result from inhibition of NF-kappaB/Rel

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

RelB-dependent stromal cells promote T-cell leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

NF-kappaB involvement in the activation of primary adult T-cell leukemia cells and its clinical implications

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Egr-1, a new downstream molecule of Epstein-Barr virus latent membrane protein 1.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Phase II trial of proteasome inhibitor bortezomib in patients with relapsed or refractory cutaneous T-cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Phase I study of proteasome inhibitor bortezomib plus CHOP in patients with advanced, aggressive T-cell or NK/T-cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Targeting autophagic regulation of NFkappaB in HTLV-I transformed cells by geldanamycin: implications for therapeutic interventions

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Inhibition of tumor necrosis factor-alpha -induced nuclear translocation and activation of NF-kappa B by dehydroxymethylepoxyquinomicin

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

The calcineurin/NFAT signaling pathway: a novel therapeutic target in leukemia and solid tumors

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Calcineurin B1 is essential for positive but not negative selection during thymocyte development

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

The NFATc1 transcription factor is widely expressed in white cells and translocates from the cytoplasm to the nucleus in a subset of human lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

In vivo evaluation of the novel calcineurin inhibitor ISATX247 in non-human primates

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Mitogen-activated protein kinases: specific messages from ubiquitous messengers

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

A requirement for sustained ERK signaling during thymocyte positive selection in vivo

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

A genomic and expression study of AP-1 in primary cutaneous T-cell lymphoma: evidence for dysregulated expression of JUNB and JUND in MF and SS.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

p38-MAP kinase activation followed by BIM induction is essential for glucocorticoid-induced apoptosis in lymphoblastic leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Proapoptotic activity of new glutathione S-transferase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor.

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Role of the protein kinase C-epsilon-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Cellular signaling perturbation by natural products

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https://api.crossref.org/works/10.1038%2FLEU.2009.223

7 January 2021

Identifiers

DOI

10.1038/LEU.2009.223

1 reference

PubMed ID

19865108

Dimensions Publication ID

21 August 2017

0 references

1 reference

PubMed ID

19865108