(Q37660260)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

Novel PI3K and mTOR Inhibitor NVP-BEZ235 Radiosensitizes Breast Cancer Cell Lines under Normoxic and Hypoxic Conditions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Bülent Polat

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

6

Cholpon S Djuzenova

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

5

Michael Flentje

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

4

Ulrike Kämmerer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

Sebastian Kuger

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

publication date

16 March 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

Breast Cancer : Basic and Clinical Research

12 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

page(s)

39-49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

12 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3964191/fullTextXML

inferred from PubMed Central ID database lookup

RStudio

1 reference

18 June 2022

https://europepmc.org/article/PMC/3964191

inferred from PubMed Central ID database lookup

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23 August 2017

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The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses

23 August 2017

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The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer

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Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells

23 August 2017

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Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma

23 August 2017

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23 August 2017

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The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma

23 August 2017

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Autophagy and tumorigenesis

23 August 2017

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Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics

23 August 2017

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Autophagy: assays and artifacts

23 August 2017

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Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited

23 August 2017

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The PI3K pathway as drug target in human cancer

23 August 2017

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Oxygen-mediated endocytosis in cancer

23 August 2017

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Cell proliferation regulated by estradiol receptor: Therapeutic implications.

23 August 2017

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Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations

23 August 2017

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NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

23 August 2017

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Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches

23 August 2017

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The role of autophagy in sensitizing malignant glioma cells to radiation therapy

23 August 2017

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Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

23 August 2017

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

23 August 2017

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23 August 2017

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Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.

23 August 2017

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Triple negative tumours: a critical review

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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Autophagy in cancer: good, bad, or both?

23 August 2017

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HIF-1 and tumour radiosensitivity

23 August 2017

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The TOR pathway: a target for cancer therapy

23 August 2017

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

23 August 2017

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The p53 pathway in breast cancer

23 August 2017

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

23 August 2017

1 reference

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NVP-BEZ235, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, prominently enhances radiosensitivity of prostate cancer cell line PC-3.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Radiosensitization of Glioblastoma Cell Lines by the Dual PI3K and mTOR Inhibitor NVP-BEZ235 Depends on Drug-Irradiation Schedule.

6 September 2017

1 reference

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The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

6 September 2017

1 reference

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Radiosensitization of prostate cancer cells by the dual PI3K/mTOR inhibitor BEZ235 under normoxic and hypoxic conditions.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy.

6 September 2017

1 reference

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New strategies for targeting the hypoxic tumour microenvironment in breast cancer

6 September 2017

1 reference

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PI3 kinase inhibitors in the clinic: an update

6 September 2017

1 reference

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NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity

6 September 2017

1 reference

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Targeting the PI3K signaling pathway in cancer therapy

6 September 2017

1 reference

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Current management and treatment strategies for breast cancer

6 September 2017

1 reference

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Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences

6 September 2017

1 reference

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The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Akt signaling pathway: a target for radiosensitizing human malignant glioma.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39.

14 September 2017

1 reference

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NVP-BEZ235 as a new therapeutic option for sarcomas.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Mutual regulation of hypoxia-inducible factor and mammalian target of rapamycin as a function of oxygen availability

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

An optimized method for measurement of gamma-H2AX in blood mononuclear and cultured cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Radiosensitization of cervical cancer cells via double-strand DNA break repair inhibition.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964191

Mutation of the PIK3CA gene in ovarian and breast cancer

1 September 2018

1 reference

12 December 2020

Effects of reoxygenation on repair of potentially lethal radiation damage in cultured MG-63 osteosarcoma cells

1 reference

12 December 2020

The effect of DN (dominant-negative) Ku70 and reoxygenation on hypoxia cell-kill: evidence of hypoxia-induced potentially lethal damage

1 reference

12 December 2020

Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature

1 reference

12 December 2020

Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry

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12 December 2020

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements

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12 December 2020

Prevention of phosphatidylinositol 3'-kinase-Akt survival signaling pathway during topotecan-induced apoptosis

1 reference

12 December 2020

Identifiers

DOI

10.4137/BCBCR.S13693

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24678241%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

24678241

1 reference