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29 February 2020

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Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era (English)

1 reference

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29 February 2020

0 references

7 references

14 March 2019

20 June 2019

13 September 2019

16 September 2019

7 October 2019

20 November 2020

25 November 2020

biological adaptation

1 reference

13 September 2019

1 reference

16 September 2019

1 reference

20 November 2020

1 reference

25 November 2020

1

1 reference

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29 February 2020

Peter A. Robbins

series ordinal

2

1 reference

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Nayia Petousi

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Peter A Robbins

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21 August 2017

language of work or name

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publication date

7 November 2013

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Journal of Applied Physiology

29 February 2020

1 April 2014

2 references

20 November 2020

25 November 2020

8 references

14 March 2019

20 June 2019

13 September 2019

16 September 2019

7 October 2019

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116

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issue

7

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29 February 2020

page(s)

875-884

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Creative Commons Attribution

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copyright license

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on focus list of Wikimedia project

ScienceSource

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Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data

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Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders

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23 August 2017

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Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth

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23 August 2017

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A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove

23 August 2017

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Role of hypoxia-inducible transcription factors 1alpha and 2alpha in the regulation of plasminogen activator inhibitor-1 expression in a human trophoblast cell line

23 August 2017

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Two routes to functional adaptation: Tibetan and Andean high-altitude natives

23 August 2017

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The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness

23 August 2017

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Acute postnatal ablation of Hif-2alpha results in anemia

23 August 2017

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Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

23 August 2017

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Genomic insights into positive selection

23 August 2017

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Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

23 August 2017

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Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation

23 August 2017

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Consensus statement on chronic and subacute high altitude diseases

23 August 2017

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Oxygen sensing by HIF hydroxylases

23 August 2017

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23 August 2017

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An Ethiopian pattern of human adaptation to high-altitude hypoxia

23 August 2017

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Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

23 August 2017

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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

23 August 2017

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Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha

23 August 2017

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

23 August 2017

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

23 August 2017

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The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

23 August 2017

1 reference

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Comparative aspects of high-altitude adaptation in human populations.

23 August 2017

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

23 August 2017

1 reference

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Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

23 August 2017

1 reference

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Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara

23 August 2017

1 reference

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

23 August 2017

1 reference

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Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives.

23 August 2017

1 reference

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

23 August 2017

1 reference

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Control of erythropoiesis in humans during prolonged exposure to the altitude of 6,542 m.

23 August 2017

1 reference

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Differences in mtDNA whole sequence between Tibetan and Han populations suggesting adaptive selection to high altitude

23 August 2017

1 reference

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Peopling the Tibetan plateau: insights from archaeology

6 September 2017

1 reference

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The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Time domains of the hypoxic ventilatory response

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Prevalence of stroke at high altitude (3380 m) in Cuzco, a town of Peru. A population-based study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Ventilation and hypoxic ventilatory responsiveness in Chinese-Tibetan residents at 3,658 m.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Altitude and birth weight

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Lack of smooth muscle in the small pulmonary arteries of the native Ladakhi. Is the Himalayan highlander adapted?

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Are Tibetans better adapted?

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high-altitude adaptation

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

A genome-wide search for signals of high-altitude adaptation in Tibetans

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Hemoglobin levels in Qinghai-Tibet: different effects of gender for Tibetans vs. Han.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Hematological differences during growth among Tibetans and Han Chinese born and raised at high altitude in Qinghai, China

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Pulmonary nitric oxide in mountain dwellers

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Oxygen transport in tibetan women during pregnancy at 3,658 m.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Quantitative genetic analysis of arterial oxygen saturation in Tibetan highlanders.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Minimal hypoxic pulmonary hypertension in normal Tibetans at 3,658 m.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Maternal oxygen delivery is not related to altitude- and ancestry-associated differences in human fetal growth

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

[Comparison study on uterine and umbilical artery blood flow during pregnancy at high altitude and at low altitude]

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Tibetan protection from intrauterine growth restriction (IUGR) and reproductive loss at high altitude

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

The effect of high altitude and other risk factors on birthweight: independent or interactive effects?

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Hypoxic ventilatory responsiveness in Tibetan compared with Han residents of 3,658 m

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Protection from intrauterine growth retardation in Tibetans at high altitude

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Human adaptability approach to nutritional assessment: a Bolivian example

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Control of breathing in Sherpas at low and high altitude

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Irreversible blunted respiratory sensitivity to hypoxia in high altitude natives

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Different hematologic responses to hypoxia in Sherpas and Quechua Indians

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

Pathophysiology and epidemiology of chronic mountain sickness

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972749

2 October 2018

Genetic Changes in Tibet

1 reference

Crossref

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00605.2013

Hypoxia-inducible factor-2alpha is involved in enhanced apoptosis in the placenta from pregnancies with fetal growth restriction

21 January 2018

1 reference

12 December 2020

The influence of short periods of induced acute anoxia upon pulmonary artery pressures in man

1 reference

12 December 2020

Respiratory insensitivity to hypoxia in chronically hypoxic man

1 reference

12 December 2020

Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta

1 reference

12 December 2020

10.1152/JAPPLPHYSIOL.00605.2013

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24201705%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24201705%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24201705%20AND%20SRC:MED&resulttype=core&format=json