(Q37680211)

English

Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells

scientific article published on 13 March 2014

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scholarly article

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Europe PubMed Central

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10 March 2020

Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells (English)

1 reference

Europe PubMed Central

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10 March 2020

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10 March 2020

author name string

S Sane

1

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10 March 2020

A Abdullah

2

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10 March 2020

D A Boudreau

3

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10 March 2020

R K Autenried

4

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10 March 2020

B K Gupta

5

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10 March 2020

X Wang

6

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10 March 2020

H Wang

7

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10 March 2020

E H Schlenker

8

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10 March 2020

C Telleria

10

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10 March 2020

L Huang

11

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10 March 2020

S C Chauhan

12

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10 March 2020

K Rezvani

13

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10 March 2020

publication date

13 March 2014

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10 March 2020

Cell Death and Disease

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10 March 2020

5

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10 March 2020

e1118

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10 March 2020

High levels of cleaved caspase-3 in colorectal tumour stroma predict good survival

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23 August 2017

Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.

1 reference

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23 August 2017

Ubiquitin-associated (UBA) domain in human Fas associated factor 1 inhibits tumor formation by promoting Hsp70 degradation

1 reference

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23 August 2017

Identifications small molecules inhibitor of p53-mortalin complex for cancer drug using virtual screening

1 reference

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23 August 2017

Mapping the protein interaction network of the human COP9 signalosome complex using a label-free QTAX strategy

1 reference

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23 August 2017

Sp1 expression regulates lung tumor progression.

1 reference

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23 August 2017

Wild-type p53 controls cell motility and invasion by dual regulation of MET expression

1 reference

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23 August 2017

Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme

1 reference

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23 August 2017

Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

1 reference

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23 August 2017

14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.

1 reference

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23 August 2017

p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association?

1 reference

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23 August 2017

DPEP1, expressed in the early stages of colon carcinogenesis, affects cancer cell invasiveness

1 reference

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23 August 2017

Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis

1 reference

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23 August 2017

Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26.

1 reference

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23 August 2017

Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions

1 reference

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23 August 2017

Kinetic and structural characterization of human mortalin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973214

23 August 2017

UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973214

23 August 2017

Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation

1 reference

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23 August 2017

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

1 reference

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23 August 2017

Inducing apoptosis of human colon cancer cells by an IGF-I D domain analogue peptide

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23 August 2017

Mifepristone inhibits ovarian cancer cell growth in vitro and in vivo

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23 August 2017

Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage

1 reference

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23 August 2017

Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values

1 reference

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23 August 2017

Identification of p53 regulators by genome-wide functional analysis

1 reference

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23 August 2017

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

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23 August 2017

TP53 mutation in colorectal cancer

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23 August 2017

An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where?

1 reference

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23 August 2017

Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein

1 reference

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23 August 2017

Mechanisms of p53-dependent apoptosis

1 reference

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23 August 2017

An N-terminal region of mot-2 binds to p53 in vitro

1 reference

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23 August 2017

Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2

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23 August 2017

Regulation of p53 downstream genes.

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23 August 2017

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

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23 August 2017

Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide

1 reference

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23 August 2017

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

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23 August 2017

c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity

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6 September 2017

Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines

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6 September 2017

The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53.

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6 September 2017

Ribosomal protein S14 unties the MDM2-p53 loop upon ribosomal stress

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6 September 2017

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6 September 2017

c-Abl phosphorylates Hdmx and regulates its interaction with p53.

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6 September 2017

Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.

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6 September 2017

Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells

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14 September 2017

Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin.

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14 September 2017

Synergistic tumor suppression by coexpression of FUS1 and p53 is associated with down-regulation of murine double minute-2 and activation of the apoptotic protease-activating factor 1-dependent apoptotic pathway in human non-small cell lung cancer c

1 reference

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14 September 2017

Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.

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14 September 2017

Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides.

1 reference

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14 September 2017

Role of caspase-3 in apoptosis of colon cancer cells induced by nonsteroidal anti-inflammatory drugs

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28 September 2017

Malignant transformation of NIH3T3 cells by overexpression of mot-2 protein.

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28 September 2017

Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.

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25 June 2018

Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member.

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25 June 2018

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors

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1 September 2018

Proteasomal degradation of the metabotropic glutamate receptor 1α is mediated by Homer-3 via the proteasomal S8 ATPase: Signal transduction and synaptic transmission.

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1 September 2018

Nutritional deficiency affects cell cycle status and viability in A549 cells: role of p27Kip1.

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1 September 2018

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1 September 2018

Withanone binds to mortalin and abrogates mortalin–p53 complex: Computational and experimental evidence

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Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of p53-dependent apoptosis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/CDDIS.2014.100

1 reference

Europe PubMed Central

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10 March 2020

1 reference

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10 March 2020

1 reference

Europe PubMed Central

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10 March 2020

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