(Q39310656)

10 September 2017

c-Abl phosphorylates Hdmx and regulates its interaction with p53. (English)

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10 September 2017

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Ygal Haupt

9

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Jean-Christophe Marine

object named as

Jean-Christophe Marine

6

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author name string

Valentina Zuckerman

1

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10 September 2017

Kristiaan Lenos

2

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10 September 2017

Grzegorz M Popowicz

3

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10 September 2017

Isabelle Silberman

4

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10 September 2017

Tamar Grossman

5

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10 September 2017

Tad A Holak

7

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10 September 2017

Aart G Jochemsen

8

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10 September 2017

language of work or name

English

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publication date

15 December 2008

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Journal of Biological Chemistry

10 September 2017

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10 September 2017

284

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10 September 2017

6

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10 September 2017

4031-4039

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p53 in health and disease

10 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

MDMX: from bench to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

The p53-Mdm2 module and the ubiquitin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Mdmx as an essential regulator of p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Inactivation of the p53 pathway in retinoblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

MDM2 interacts with MDMX through their RING finger domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

MDM2 promotes ubiquitination and degradation of MDMX

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

DNA damage-induced MDMX degradation is mediated by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

MDM2 and MDM4: p53 regulators as targets in anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

The p53 response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

C-Abl as a modulator of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Role of c-Abl in the DNA damage stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Death by Abl: a matter of location

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

c-Abl phosphorylates Hdm2 at tyrosine 276 in response to DNA damage and regulates interaction with ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Molecular basis for the inhibition of p53 by Mdmx

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

The P53 pathway: what questions remain to be explored?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

The complexity of p53 stabilization and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Phosphorylation of MdmX by CDK2/Cdc2(p34) is required for nuclear export of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Regulation of p53-MDMX interaction by casein kinase 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Distinct roles of MDMX in the regulation of p53 response to ribosomal stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Insights into selective activation of p53 DNA binding by c-Abl.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

c-Abl tyrosine kinase activates p21 transcription via interaction with p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M809211200

21 January 2018

Identifiers

DOI

10.1074/JBC.M809211200

1 reference

10 September 2017

1 reference