(Q37690520)

22 August 2017

1 reference

title

Transcriptional switches: chemical approaches to gene regulation (English)

1 reference

22 August 2017

Lori W Lee

1

1 reference

22 August 2017

Anna K Mapp

series ordinal

2

1 reference

22 August 2017

language of work or name

English

0 references

publication date

10 February 2010

1 reference

Journal of Biological Chemistry

22 August 2017

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22 August 2017

285

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22 August 2017

15

1 reference

22 August 2017

11033-11038

1 reference

Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Cell-permeable beta-peptide inhibitors of p53/hDM2 complexation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Inhibition of transcription factors with small organic molecules

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Small molecule inhibitors of the p53-MDM2.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Nuclear receptor drug discovery

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

A surface on the androgen receptor that allosterically regulates coactivator binding

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Design and synthesis of a cell-permeable synthetic transcription factor mimic

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

A TAD further: exogenous control of gene activation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Small molecule modulators of transcription

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

A rapid library screen for tailoring beta-peptide structure and function

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Targets of the Gal4 transcription activator in functional transcription complexes.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Chemical approaches to transcriptional regulation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Programmable DNA binding oligomers for control of transcription

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

p53 Activation by small molecules: application in oncology

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

HER-2: a biomarker at the crossroads of breast cancer immunotherapy and molecular medicine.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Function of a eukaryotic transcription activator during the transcription cycle

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Transcriptional regulation and the role of diverse coactivators in animal cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Identification of small-molecule antagonists that inhibit an activator: coactivator interaction

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Recognition of the DNA minor groove by pyrrole-imidazole polyamides

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Androgen receptor mutations and androgen insensitivity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Modular design of artificial transcription factors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Molecular mechanism of the interaction between MDM2 and p53.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Transcription factors as targets for cancer therapy

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

The genetics of the E2F family of transcription factors: shared functions and unique roles

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

p300/CBP proteins: HATs for transcriptional bridges and scaffolds

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Molecular recognition of DNA by small molecules

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

The Gal4 activation domain binds Sug2 protein, a proteasome component, in vivo and in vitro

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

CREB-binding protein and p300 in transcriptional regulation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Molecular portraits of human breast tumours

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

CBP/p300 in cell growth, transformation, and development

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

p53 and human cancer: the first ten thousand mutations.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Structure and specificity of nuclear receptor-coactivator interactions

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

p53 mutations in human cancers

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Discovery of a small-molecule inhibitor of the KIX-KID interaction

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Novel flufenamic acid analogues as inhibitors of androgen receptor mediated transcription

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Wrenchnolol derivative optimized for gene activation in cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Mechanism of coupled folding and binding of an intrinsically disordered protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Structural details on mdm2-p53 interaction

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Coactivator cross-talk specifies transcriptional output

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856975

Suppression of tumor growth through disruption of hypoxia-inducible transcription

23 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.075044

A mechanism for coordinating chromatin modification and preinitiation complex assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.075044

Recruitment of a 19S proteasome subcomplex to an activated promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.075044

Helical beta-peptide inhibitors of the p53-hDM2 interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.075044

Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.075044

Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.075044

A Gene-Expression Inhibitor that Targets an α-Helix-Mediated Protein Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.075044

Enhanced protein production by engineered zinc finger proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.075044

Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.075044

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide

21 January 2018

1 reference

12 December 2020

A cell-permeable synthetic transcription factor mimic

1 reference

12 December 2020

cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis

1 reference

12 December 2020

Transcriptional up-regulation in cells mediated by a small molecule

1 reference

12 December 2020

Expression of transcription factor CREB1 in human breast cancer and its correlation with prognosis

1 reference

12 December 2020

A small molecule transcriptional activation domain

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.R109.075044

1 reference

22 August 2017

1 reference

22 August 2017

PubMed publication ID

20147748

1 reference