(Q37696275)

22 August 2017

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title

Dependence receptors: a new paradigm in cell signaling and cancer therapy (English)

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22 August 2017

D Goldschneider

1

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22 August 2017

P Mehlen

series ordinal

2

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22 August 2017

language of work or name

English

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publication date

22 February 2010

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22 August 2017

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22 August 2017

volume

29

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22 August 2017

issue

13

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22 August 2017

page(s)

1865-1882

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ALK is a novel dependence receptor: potential implications in development and cancer

22 August 2017

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Netrin-1 acts as a survival factor for aggressive neuroblastoma

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Ephrin signalling controls brain size by regulating apoptosis of neural progenitors

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Discovery of epigenetically silenced genes in acute myeloid leukemias

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Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma

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Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

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Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.

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Mice lacking brain-derived neurotrophic factor develop with sensory deficits

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Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

31 March 2020

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Identification of a chromosome 18q gene that is altered in colorectal cancers

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer

31 March 2020

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The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation

31 March 2020

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Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor

31 March 2020

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Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application

31 March 2020

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Induction of cell death by endogenous nerve growth factor through its p75 receptor

31 March 2020

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Neogenin regulates neuronal survival through DAP kinase.

31 March 2020

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The dependence receptor DCC requires lipid raft localization for cell death signaling

31 March 2020

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Netrin-1 is a survival factor during commissural neuron navigation

31 March 2020

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EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesis.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

DAPk protein family and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Making the case for DCC and UNC5C as tumor-suppressor genes in the colon

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers

31 March 2020

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Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization

31 March 2020

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Epidermal growth factor receptor down-regulation induced by UVA in human keratinocytes does not require the receptor kinase activity.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans

31 March 2020

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The many faces of p75NTR.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion

31 March 2020

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Role of integrins in cell invasion and migration

31 March 2020

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Neurotrophins: roles in neuronal development and function

31 March 2020

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Role of membrane microdomain rafts in TNFR-mediated signal transduction

31 March 2020

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DAP kinase links the control of apoptosis to metastasis

31 March 2020

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Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

31 March 2020

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Neuronal specification in the spinal cord: inductive signals and transcriptional codes

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

The multifunctional roles of the four-and-a-half-LIM only protein FHL2.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrins and neogenin promote myotube formation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Neurotrophin signal transduction in the nervous system

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

Suppressed tumorigenicity of human endometrial cancer cells by the restored expression of the DCC gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Deleted in Colorectal Cancer (DCC) encodes a netrin receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Introduction of wild-type patched gene suppresses the oncogenic potential of human squamous cell carcinoma cell lines including A431.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

Methylation-associated silencing of death-associated protein kinase gene in laryngeal squamous cell cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Molecular communication between androgen receptor and general transcription machinery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The uniqueness of being a neurotrophin receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Regulation of cell survival by secreted proneurotrophins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.13

Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic embryonic nerve cells in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

NMR structure of the death domain of the p75 neurotrophin receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Prognostic implications of netrin-1 expression and its receptors in patients with adenocarcinoma of the pancreas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Mediation of the DCC apoptotic signal by DIP13 alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrin-1 acts as a survival factor via its receptors UNC5H and DCC.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The role of neurotrophins in axonal growth, guidance, and regeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The RET receptor: function in development and dysfunction in congenital malformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

RGM and its receptor neogenin regulate neuronal survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrin-1 controls colorectal tumorigenesis by regulating apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Role of the dependence receptor DCC in colorectal cancer pathogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The dependence receptors DCC and UNC5H as a link between neuronal guidance and survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Dependence receptors: between life and death.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Identification and characterization of neogenin, a DCC-related gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Interfering with multimerization of netrin-1 receptors triggers tumor cell death.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

RGM is a repulsive guidance molecule for retinal axons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Sonic hedgehog signaling by the patched-smoothened receptor complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Androgen receptor CAG repeats and prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Eph receptor signalling casts a wide net on cell behaviour

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Specificity in the crosstalk of TGFbeta/GDNF family members is determined by distinct GFR alpha receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Expression of p75NTR in a human prostate epithelial tumor cell line reduces nerve growth factor-induced cell growth by activation of programmed cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Divergent properties of mouse netrins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Induction of apoptosis by the low-affinity NGF receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Neogenin mediates the action of repulsive guidance molecule

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The netrin protein family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

DAP kinase-a proapoptotic gene that functions as a tumor suppressor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

EphrinB3 regulates cell proliferation and survival in adult neurogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumor growth and metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Expression of DCC protein in colorectal tumors and its relationship to tumor progression and metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Isolation and expression pattern of three mouse homologues of chick Rgm

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Determinants of ligand binding specificity in the glial cell line-derived neurotrophic factor family receptor alpha S.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The DCC protein and prognosis in colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Lipid rafts and signal transduction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Caspase cleavage of HER-2 releases a Bad-like cell death effector

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Integrins as a distinct subtype of dependence receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Potentiation of neuroblastoma metastasis by loss of caspase-8.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Expression of the deleted in colorectal cancer gene is related to prognosis in DNA diploid and low proliferative colorectal adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

p53RDL1 regulates p53-dependent apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

31 March 2020

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Identification of proteolytic fragments from ErbB-2 that induce apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Dimerization-dependent block of the proapoptotic effect of p75(NTR)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

The role of hedgehog signalling in tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Netrins promote developmental and therapeutic angiogenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Neogenin interacts with RGMa and netrin-1 to guide axons within the embryonic vertebrate forebrain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Expression and function of Trk-C in favourable human neuroblastomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.13

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.13

1 reference

22 August 2017

1 reference