(Q37697804)

22 August 2017

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title

Non-animal sensitization testing: state-of-the-art (English)

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22 August 2017

2

Henk van Loveren

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author name string

Rob J Vandebriel

series ordinal

1

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22 August 2017

language of work or name

English

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publication date

1 May 2010

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Critical Reviews in Toxicology

22 August 2017

published in

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22 August 2017

volume

40

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22 August 2017

issue

5

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22 August 2017

page(s)

389-404

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HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway.

22 August 2017

cites work

1 reference

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Characterization of the sensitizing potential of chemicals by in vitro analysis of dendritic cell activation and skin penetration

21 January 2018

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p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene

21 January 2018

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Skin inflammation during contact hypersensitivity is mediated by early recruitment of CD8+ T cytotoxic 1 cells inducing keratinocyte apoptosis.

21 January 2018

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Reactivity profiling: covalent modification of single nucleophile peptides for skin sensitization risk assessment.

21 January 2018

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Skin sensitization: reaction mechanistic applicability domains for structure-activity relationships

21 January 2018

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Animal models to test respiratory allergy of low molecular weight chemicals: a guidance

21 January 2018

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The respiratory local lymph node assay as a tool to study respiratory sensitizers

21 January 2018

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Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol

21 January 2018

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The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers.

21 January 2018

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Toxicogenomics in the assessment of immunotoxicity.

21 January 2018

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The human repeated insult patch test in the 21st century: a commentary

21 January 2018

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Information derived from sensitization test methods: test sensitivity, false positives and false negatives

21 January 2018

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In vitro approaches to the identification and characterization of skin sensitizers

21 January 2018

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Threshold for classification as a skin sensitizer in the local lymph node assay: a statistical evaluation.

21 January 2018

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Identification and classification of skin sensitizers: identifying false positives and false negatives

21 January 2018

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Does irritation potency contribute to the skin sensitization potency of contact allergens?

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408440903524262

Coupling of contact sensitizers to thiol groups is a key event for the activation of monocytes and monocyte-derived dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

A skin-like cytochrome P450 cocktail activates prohaptens to contact allergenic metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epidermis and normal human skin; transcriptional effects of retinoid treatments in reconstituted human epidermis

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408440903524262

Kinetic glutathione chemoassay to quantify thiol reactivity of organic electrophiles--application to alpha,beta-unsaturated ketones, acrylates, and propiolates

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408440903524262

Respiratory sensitization and allergy: current research approaches and needs

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408440903524262

Thiol antioxidants block the activation of antigen-presenting cells by contact sensitizers

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408440903524262

Monitoring the European standard series in 10 centres 1996-2000.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408440903524262

Identification of a novel population of Langerin+ dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Chemicals with weak skin sensitizing properties can be identified using low-density microarrays on immature dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Multivariate QSAR analysis of a skin sensitization database

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

ICCVAM evaluation of the murine local lymph node assay. Conclusions and recommendations of an independent scientific peer review panel

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Ranking of allergenic potency of rubber chemicals in a modified local lymph node assay

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Phenotypic alterations and IL-1beta production in CD34(+) progenitor- and monocyte-derived dendritic cells after exposure to allergens: a comparative analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Hapten-protein binding: from theory to practical application in the in vitro prediction of skin sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Electrophilic reaction chemistry of low molecular weight respiratory sensitizers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Structure-activity models for contact sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Paraben dermatitis due to a new medicated bandage: The “paraben paradox”

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

The relationships between exposure dose and response in induction and elicitation of contact hypersensitivity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Transcriptional profiling of epidermal keratinocytes: comparison of genes expressed in skin, cultured keratinocytes, and reconstituted epidermis, using large DNA microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Development of a peptide reactivity assay for screening contact allergens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Investigation of peptide reactivity of pro-hapten skin sensitizers using a peroxidase-peroxide oxidation system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Xenobiotic metabolism in human skin and 3D human skin reconstructs: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice. Evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic cont

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Proposal for a risk assessment methodology for skin sensitization based on sensitization potency data

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

In vitro human T cell sensitization to haptens by monocyte-derived dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

ICCVAM evaluation of the murine local lymph node assay. Data analyses completed by the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

A cell-based in vitro alternative to identify skin sensitizers by gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Relationship between chemical structure and the occupational asthma hazard of low molecular weight organic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Structure-activity relationships and computer-assisted analysis of respiratory sensitization potential

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

PTEN down-regulates IL-17 expression in a murine model of toluene diisocyanate-induced airway disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

A murine local lymph node assay for the identification of contact allergens. Assay development and results of an initial validation study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Chemical respiratory allergy: role of IgE antibody and relevance of route of exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Allergic contact dermatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Dose metrics in the acquisition of skin sensitization: thresholds and importance of dose per unit area

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

In vitro differentiation of skin sensitizers by cell signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

In vitro primary sensitization of hapten-specific T cells by cultured human epidermal Langerhans cells--a screening predictive assay for contact sensitizers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Occupational allergic contact dermatitis is more prevalent than irritant contact dermatitis: a 5-year study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

THP-1 monocytes but not macrophages as a potential alternative for CD34+ dendritic cells to identify chemical skin sensitizers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

A review of critical factors in the conduct and interpretation of the human repeat insult patch test.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for skin sensitizers--functional relevance and a hypothesis on innate reactions to skin sensitizers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Skin sensitizers induce antioxidant response element dependent genes: application to the in vitro testing of the sensitization potential of chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Filling the concept with data: integrating data from different in vitro and in silico assays on skin sensitizers to explore the battery approach for animal-free skin sensitization testing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis. Implications for sustained dendritic cell activation in the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Modelling the human epidermis in vitro: tools for basic and applied research

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Assessing immunotoxicity: guidelines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Assessment of the U937 cell line for the detection of contact allergens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

High throughput kinetic profiling approach for covalent binding to peptides: application to skin sensitization potency of Michael acceptor electrophiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Electrophilic chemistry related to skin sensitization. Reaction mechanistic applicability domain classification for a published data set of 106 chemicals tested in the mouse local lymph node assay

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Chemical reactivity indices and mechanism-based read-across for non-animal based assessment of skin sensitisation potential

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Respiratory immunotoxicity: an in vitro assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

A three-dimensional cellular model of the human respiratory tract to study the interaction with particles

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Evaluation of the capacity of dendritic cells derived from cord blood CD34+ precursors to present haptens to unsensitized autologous T cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

In vitro evaluation of the sensitization potential of weak contact allergens using langerhans-like dendritic cells and autologous T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Dendritic cells and skin sensitization: biological roles and uses in hazard identification

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

ICCVAM evaluation of the murine local lymph node assay. The ICCVAM review process

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test--human cell line activation test (h-CLAT).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Chemical substances and contact allergy—244 substances ranked according to allergenic potency

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

A loose-fit coculture of activated keratinocytes and dendritic cell-related cells for prediction of sensitizing potential

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Structure-activity relationships for reactivity of carbonyl-containing compounds with glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Read-across to rank skin sensitization potential: subcategories for the Michael acceptor domain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Methods for the prediction of low-molecular-weight occupational respiratory sensitizers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Microarray analysis of gene expression in cultured skin substitutes compared with native human skin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Gene expression studies in cultured dendritic cells: new indicators for the discrimination of skin sensitizers and irritants in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Disparate cytotoxic activity of nickel-specific CD8+ and CD4+ T cell subsets against keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Characterization of early events involved in human dendritic cell maturation induced by sensitizers: cross talk between MAPK signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Reconstruction of three-dimensional human skin model composed of dendritic cells, keratinocytes and fibroblasts utilizing a handy scaffold of collagen vitrigel membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Assessment of preferential T-helper 1 or T-helper 2 induction by low molecular weight compounds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-gamma and interleukin-4

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Impact of exposure duration by low molecular weight compounds on interferon-gamma and interleukin-4 mRNA expression and production in the draining lymph nodes of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

In vitro assessment of sensitizing activity of low molecular weight compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

A quantitative method for assessing the sensitizing potency of low molecular weight chemicals using a local lymph node assay: employment of a regression method that includes determination of the uncertainty margins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1alpha and IL-18 production by a murine and human keratinocyte cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Gene profiles of a human bronchial epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Gene profiles of a human alveolar epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Toxicogenomics and systems toxicology: aims and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Experimental study for the development of an in vitro test for contact allergens. 1. Primary activation of hapten-specific T cells by hapten-conjugated epidermal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

The local lymph node assay compared with the human maximization test as an indicator of allergic potency in humans using patch test clinic populations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903524262

10.3109/10408440903524262

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference