(Q37698685)

22 August 2017

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title

Progress in the genetics of common obesity and type 2 diabetes (English)

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22 August 2017

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2

Ruth J F Loos

1 reference

PubMed ID

20184785

22 August 2017

Karani S. Vimaleswaran

series ordinal

1

object named as

Karani S Vimaleswaran

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22 August 2017

26 February 2010

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Expert Reviews in Molecular Medicine

22 August 2017

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22 August 2017

12

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22 August 2017

e7

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The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

22 August 2017

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Common variants near MC4R are associated with fat mass, weight and risk of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Variation in FTO contributes to childhood obesity and severe adult obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Meta-Analysis of Genome-wide Linkage Studies in BMI and Obesity*

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Common Variants in the ENPP1 Gene Are Not Reproducibly Associated With Diabetes or Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

BDNF regulates eating behavior and locomotor activity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Common nonsynonymous variants in PCSK1 confer risk of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Trp64Arg mutation of beta3-adrenoceptor gene deteriorates lipolysis induced by beta3-adrenoceptor agonist in human omental adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

A genome-wide association study identifies novel risk loci for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

A second generation human haplotype map of over 3.1 million SNPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genome-wide association studies in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Time of Onset of Non-Insulin-Dependent Diabetes Mellitus and Genetic Variation in the β3-Adrenergic–Receptor Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Melanocortin-4 receptor gene variant I103 is negatively associated with obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

The biochemical effect of the naturally occurring Trp64-->Arg mutation on human beta3-adrenoceptor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

The new type 2 diabetes gene TCF7L2

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Practical aspects of imputation-driven meta-analysis of genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Common variants in WFS1 confer risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genome-wide association studies provide new insights into type 2 diabetes aetiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Candidate-gene approaches for studying complex genetic traits: practical considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Physical activity and the association of common FTO gene variants with body mass index and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

The human obesity gene map: the 2005 update

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance--a population-based twin study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Regulation of Fto/Ftm gene expression in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Inactivation of the Fto gene protects from obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Heritability of obesity-related traits among Nigerians, Jamaicans and US black people

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Untangling genetic influences on smoking, body mass index and longevity: a multivariate study of 2464 Danish twins followed for 28 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genetic epidemiology of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Clinical risk factors, DNA variants, and the development of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genotype score in addition to common risk factors for prediction of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Variants in MTNR1B influence fasting glucose levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Genetic and environmental factors in relative body weight and human adiposity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Lifetime Risk for Diabetes Mellitus in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Body-mass index and mortality in Korean men and women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Prevalence of overweight and obesity in the United States, 1999-2004

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Excess deaths associated with underweight, overweight, and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Physical activity attenuates the body mass index–increasing influence of genetic variation in the FTO gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

Daily energy expenditure in Mexican and USA Pima indians: low physical activity as a possible cause of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Progress in the genetics of common obesity: size matters

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Effects of a traditional lifestyle on obesity in Pima Indians

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

A twin study of human obesity.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Association Studies of Genetic Variation in the WFS1 Gene and Type 2 Diabetes in U.K. Populations

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Human genetics illuminates the paths to metabolic disease

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Antiobesity and antidiabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Genetic dissection of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Québec family study

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Gene-environment interactions and obesity--further aspects of genomewide association studies

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

An Adoption Study of Human Obesity

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Mouse models of insulin resistance

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Obesity and the environment: where do we go from here?

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

Association of codon 16 and codon 27 beta 2-adrenergic receptor gene polymorphisms with obesity: a meta-analysis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

No Evidence of Association of ENPP1 Variants With Type 2 Diabetes or Obesity in a Study of 8,089 U.K. Caucasians

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001389

7 January 2021

10.1017/S1462399410001389

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20184785