(Q37711135)

22 August 2017

1 reference

title

Molecular mechanism of pancreatic cancer--understanding proliferation, invasion, and metastasis (English)

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22 August 2017

3

Helmut Friess

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22 August 2017

André L Mihaljevic

1

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22 August 2017

Christoph W Michalski

series ordinal

2

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22 August 2017

Jörg Kleeff

series ordinal

4

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22 August 2017

language of work or name

English

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publication date

18 March 2010

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Langenbeck's Archives of Surgery

22 August 2017

published in

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22 August 2017

volume

395

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22 August 2017

issue

4

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22 August 2017

page(s)

295-308

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https://scigraph.springernature.com/pub.10.1007/s00423-010-0622-5

22 August 2017

exact match

0 references

cites work

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Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis

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Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia

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Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer

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Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

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The interaction of Ras with GTPase-activating proteins

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12 December 2020

Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of th

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12 December 2020

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

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12 December 2020

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells

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Nuclear factor-kappa B and cancer: its role in prevention and therapy

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12 December 2020

Identification of pancreatic cancer stem cells

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12 December 2020

TGF-beta and epithelial-to-mesenchymal transitions

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12 December 2020

Intercellular signals regulating pancreas development and function

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12 December 2020

The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer

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12 December 2020

Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance

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12 December 2020

Rapamycin-induced endothelial cell death and tumor vessel thrombosis potentiate cytotoxic therapy against pancreatic cancer

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12 December 2020

A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development.

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12 December 2020

Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer

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12 December 2020

Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.

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12 December 2020

Ral-GTPases: approaching their 15 minutes of fame

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12 December 2020

Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.

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12 December 2020

Expression of E-cadherin, alpha- and beta-catenins in patients with pancreatic adenocarcinoma.

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12 December 2020

Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis

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12 December 2020

High interstitial fluid pressure - an obstacle in cancer therapy

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12 December 2020

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12 December 2020

It's a free for all--insulin-positive cells join the group of potential progenitors for pancreatic ductal adenocarcinoma

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12 December 2020

Tumor growth need not be driven by rare cancer stem cells

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12 December 2020

Centrosome abnormalities in pancreatic ductal carcinoma.

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12 December 2020

p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma

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12 December 2020

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

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12 December 2020

Tumor suppression through angiogenesis inhibition by SUIT-2 pancreatic cancer cells genetically engineered to secrete NK4.

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12 December 2020

Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression.

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12 December 2020

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

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12 December 2020

Current standards of surgery for pancreatic cancer.

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12 December 2020

p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

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12 December 2020

TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

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12 December 2020

Pancreatic stem cells

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12 December 2020

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

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12 December 2020

Met, metastasis, motility and more

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12 December 2020

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

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12 December 2020

Increased expression of NF-kappa B subunits in human pancreatic cancer cells

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12 December 2020

The Hallmarks of Cancer

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12 December 2020

BRAF and K-ras gene mutations in human pancreatic cancers.

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12 December 2020

Genetics and biology of pancreatic ductal adenocarcinoma.

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12 December 2020

Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells

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12 December 2020

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

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12 December 2020

The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells

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12 December 2020

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

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12 December 2020

Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray

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12 December 2020

Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy

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12 December 2020

Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway.

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12 December 2020

Human pancreatic cancer cells disable function of Fas receptors at several levels in Fas signal transduction pathway

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12 December 2020

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

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12 December 2020

Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy

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12 December 2020

NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells

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12 December 2020

Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in pancreatic cancers

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12 December 2020

Hedgehog signaling in animal development: paradigms and principles

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12 December 2020

The neurotrophic factor artemin promotes pancreatic cancer invasion

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12 December 2020

Function of nuclear factor kappaB in pancreatic cancer metastasis

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12 December 2020

Analysis of the invasion-metastasis mechanism in pancreatic cancer: involvement of plasmin(ogen) cascade proteins in the invasion of pancreatic cancer cells.

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12 December 2020

Apoptotic index or a combination of Bax/Bcl-2 expression correlate with survival after resection of pancreatic adenocarcinoma.

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12 December 2020

Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression

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12 December 2020

Increasing complexity of Ras signaling.

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12 December 2020

The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma

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12 December 2020

DPC4/Smad4 Expression and Outcome in Pancreatic Ductal Adenocarcinoma

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12 December 2020

Progression model for pancreatic cancer.

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12 December 2020

The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer

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12 December 2020

Creation of human tumour cells with defined genetic elements

1 reference

12 December 2020

Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity

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12 December 2020

A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

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12 December 2020

The increasing complexity of the cancer stem cell paradigm

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12 December 2020

Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas.

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12 December 2020

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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12 December 2020

Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer

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12 December 2020

The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma

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12 December 2020

Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells

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12 December 2020

JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells.

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12 December 2020

RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

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12 December 2020

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

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12 December 2020

MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells

1 reference

12 December 2020

Induction and expression of amphiregulin in human pancreatic cancer.

1 reference

12 December 2020

Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer

1 reference

12 December 2020

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

1 reference

12 December 2020

New signals from the invasive front

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12 December 2020

K-ras mutations in pancreatic ductal proliferative lesions

1 reference

12 December 2020

N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma

1 reference

12 December 2020

Tumor-suppressive pathways in pancreatic carcinoma.

1 reference

12 December 2020

Second nature: biological functions of the Raf-1 "kinase"

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12 December 2020

Consensus transcriptome signature of perineural invasion in pancreatic carcinoma

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12 December 2020

Ductal metaplasia of human exocrine pancreas and its association with carcinoma

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12 December 2020

Inhibition of growth, invasion, and metastasis of human pancreatic carcinoma cells by NK4 in an orthotopic mouse model

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12 December 2020

Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses

1 reference

12 December 2020

Adenovirus-mediated transfer of a truncated fibroblast growth factor (FGF) type I receptor blocks FGF-2 signaling in multiple pancreatic cancer cell lines

1 reference

12 December 2020

Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice

1 reference

12 December 2020

Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis

1 reference

12 December 2020

Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancer

1 reference

12 December 2020

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas

1 reference

12 December 2020

Notch signaling controls multiple steps of pancreatic differentiation

1 reference

12 December 2020

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

1 reference

12 December 2020

Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.

1 reference

12 December 2020

Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles.

1 reference

12 December 2020

Multiple and synergistic deregulations of apoptosis-controlling genes in pancreatic carcinoma cells

1 reference

12 December 2020

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1 reference

12 December 2020

Understanding the Warburg effect: the metabolic requirements of cell proliferation

1 reference

12 December 2020

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

1 reference

12 December 2020

Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer

1 reference

12 December 2020

Activation of RalA is critical for Ras-induced tumorigenesis of human cells.

1 reference

12 December 2020

FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition

1 reference

12 December 2020

An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation

1 reference

12 December 2020

Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin

1 reference

12 December 2020

Murine pancreatic ductal adenocarcinoma produced by in vitro transduction of polyoma middle T oncogene into the islets of Langerhans

1 reference

12 December 2020

The phosphoinositide 3-kinase pathway

1 reference

12 December 2020

A phase II study of bevacizumab plus erlotinib for gemcitabine-refractory metastatic pancreatic cancer

1 reference

12 December 2020

Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras

1 reference

12 December 2020

1 reference

12 December 2020

RAS oncogenes: the first 30 years.

1 reference

12 December 2020

The rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation

1 reference

12 December 2020

The love-hate relationship between Ras and Notch.

1 reference

12 December 2020

Dominant negative MEKK1 inhibits survival of pancreatic cancer cells

1 reference

12 December 2020

Pancreatic cancer stem cells: implications for the treatment of pancreatic cancer

1 reference

12 December 2020

Hypoxia and defective apoptosis drive genomic instability and tumorigenesis

1 reference

12 December 2020

Tumor initiating cells in pancreatic cancer: A critical view.

1 reference

12 December 2020

Cancer statistics, 2007

1 reference

12 December 2020

Bcl-2 expression in pancreas development and pancreatic cancer progression

1 reference

12 December 2020

10.1007/S00423-010-0622-5

Identifiers

DOI

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30 July 2022

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Fatcat

https://api.fatcat.wiki/v0/release/zpqaovqu7jh4vnrs556dkqoluq

30 July 2022

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https://api.fatcat.wiki/v0/release/zpqaovqu7jh4vnrs556dkqoluq

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30 July 2022