(Q37724780)

22 August 2017

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title

Cathepsin L in metastatic bone disease: therapeutic implications (English)

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22 August 2017

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Gaetano Leto

1

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22 August 2017

Maria Vittoria Sepporta

2

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22 August 2017

Marilena Crescimanno

3

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22 August 2017

Carla Flandina

4

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22 August 2017

Francesca Maria Tumminello

5

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22 August 2017

publication date

1 June 2010

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22 August 2017

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22 August 2017

volume

391

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22 August 2017

issue

6

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22 August 2017

page(s)

655-664

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Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment

22 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Dipeptidyl nitrile inhibitors of Cathepsin L

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called "stratum corneum thiol protease" as cathepsin l2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Design of selective Cathepsin inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

The consequences of lysosomotropism on the design of selective cathepsin K inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

The dual role of IL-6-type cytokines on bone remodeling and bone tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Different cysteine proteinases involved in bone resorption and osteoclast formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Family 2 cystatins inhibit osteoclast-mediated bone resorption in calvarial bone explants

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cysteine cathepsins: cellular roadmap to different functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin K inhibitors for osteoporosis and potential off-target effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin L splice variants in human breast cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

The type II collagen fragments Helix-II and CTX-II reveal different enzymatic pathways of human cartilage collagen degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Involvement of carboxy-terminal amino acids in secretion of human lysosomal protease cathepsin L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Matrigel invasion by the prostate cancer cell lines, PC3 and DU145, and cathepsin L+B activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Biosynthesis and alternate targeting of the lysosomal cysteine protease cathepsin L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: contrasting, overlapping and compensatory functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Effect of cathepsin k inhibitor basicity on in vivo off-target activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Characterization of 3 oral squamous cell carcinoma cell lines with different invasion and/or metastatic potentials

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Intratumoral gene delivery of anti-cathepsin L single-chain variable fragment by lentiviral vector inhibits tumor progression induced by human melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsins B, H, L and cysteine protease inhibitors in malignant prostate cell lines, primary cultured prostatic cells and prostatic tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Inhibitory effect of the sugarcane cystatin CaneCPI-4 on cathepsins B and L and human breast cancer cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cysteine cathepsins and the cutting edge of cancer invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Identification of secreted glycoproteins of human prostate and bladder stromal cells by comparative quantitative proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsins in the osteoclast

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Significance of 32-kDa cathepsin L secreted from cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Inhibition of bone resorption by selective inactivators of cysteine proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

The lysosomal cysteine proteases in MHC class II antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsins and osteosarcoma: Expression analysis identifies cathepsin K as an indicator of metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Structure-based design of specific cathepsin inhibitors and their application to protection of bone metastases of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Transcriptional upregulation of human cathepsin L by VEGF in glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis: a parallel investigation by semiquantitative reverse transcriptase-polymerase chain rea

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Disease-specific expression patterns of proteases in synovial tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Antiprotease therapy in cancer: hot or not?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Soluble cathepsin-L: a marker of bone resorption and bone density?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin L, target in cancer treatment?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin K inhibitors as treatment of bone metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Regulation of collagenase activities of human cathepsins by glycosaminoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin K is the principal protease in giant cell tumor of bone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Oligogalacturonic acid inhibit bone resorption and collagen degradation through its interaction with type I collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Treatment of bone metastases and bone pain with bisphosphonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

From furless to heartless-unraveling the diverse functions of cathepsin L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

The plasminogen activator system and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cysteine cathepsins: multifunctional enzymes in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Metastasis to bone: causes, consequences and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Family C1 cysteine proteases: biological diversity or redundancy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cysteine cathepsin proteases as pharmacological targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

RANK ligand and interferon gamma differentially regulate cathepsin gene expression in pre-osteoclastic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

E-cadherin and beta-catenin loss of expression related to bone metastasis in prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cysteine proteinases in chondrosarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Lysosomal cysteine cathepsins: signaling pathways in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cystatins: biochemical and structural properties, and medical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin L is required for endothelial progenitor cell-induced neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Expression of cathepsins B, H, K, L, and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and endochondral ossification in mouse fracture callus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Pericellular proteases in angiogenesis and vasculogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin L increases invasion and migration of B16 melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Expression of cysteine peptidase cathepsin L and its inhibitors stefins A and B in relation to tumorigenicity of breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Senescence-initiated reversal of drug resistance: specific role of cathepsin L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin L inhibition suppresses drug resistance in vitro and in vivo: a putative mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cysteine proteases: destruction ability versus immunomodulation capacity in immune cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

Cathepsin B and L activities in isolated osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2010.069

21 January 2018

Identifiers

DOI

10.1515/BC.2010.069

1 reference

22 August 2017

1 reference