(Q33525418)

27 July 2017

title

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors (English)

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27 July 2017

Kevin G Pinney

11

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author name string

G D Kishore Kumar

1

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27 July 2017

Gustavo E Chavarria

2

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27 July 2017

Amanda K Charlton-Sevcik

3

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Wara M Arispe

4

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27 July 2017

Matthew T Macdonough

5

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27 July 2017

Tracy E Strecker

6

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27 July 2017

Shen-En Chen

7

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27 July 2017

Bronwyn G Siim

8

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27 July 2017

David J Chaplin

9

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27 July 2017

Mary Lynn Trawick

10

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27 July 2017

language of work or name

English

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publication date

6 January 2010

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Bioorganic & Medicinal Chemistry Letters

27 July 2017

published in

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27 July 2017

volume

20

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27 July 2017

issue

4

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27 July 2017

page(s)

1415-1419

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Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.

27 July 2017

cites work

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12 December 2020

Systematic variation in gene expression patterns in human cancer cell lines

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12 December 2020

Peptidic 1-cyanopyrrolidines: synthesis and SAR of a series of potent, selective cathepsin inhibitors

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12 December 2020

Antimalarial activity of thiosemicarbazones and purine derived nitriles.

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12 December 2020

Azepanone-based inhibitors of human cathepsin L.

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12 December 2020

Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease

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12 December 2020

Cysteine cathepsins: multifunctional enzymes in cancer

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12 December 2020

Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption

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12 December 2020

Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins

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12 December 2020

Purification and Properties of a New Cathepsin from Rat Liver1

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12 December 2020

Cysteine cathepsins in human cancer

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12 December 2020

Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues

1 reference

12 December 2020

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi

1 reference

12 December 2020

Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain

1 reference

12 December 2020

Identification of Leishmania major cysteine proteinases as targets of the immune response in humans

1 reference

12 December 2020

Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype

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12 December 2020

Emerging roles of cysteine cathepsins in disease and their potential as drug targets.

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12 December 2020

Lysosomal cysteine proteases: facts and opportunities

1 reference

12 December 2020

Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.

1 reference

12 December 2020

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

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12 December 2020

Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor

1 reference

12 December 2020

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

1 reference

12 December 2020

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain

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12 December 2020

Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

1 reference

12 December 2020

Cathepsin B is a target of Hedgehog signaling in pancreatic cancer

1 reference

12 December 2020

Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells

1 reference

12 December 2020

Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors

1 reference

12 December 2020

Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides

1 reference

12 December 2020

Dipeptidyl nitrile inhibitors of Cathepsin L

1 reference

12 December 2020

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB

1 reference

12 December 2020

10.1016/J.BMCL.2009.12.090

Identifiers

DOI

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27 July 2017

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