(Q37756117)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20481652%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

review article

1 reference

title

Overcoming reduced glucocorticoid sensitivity in airway disease: molecular mechanisms and therapeutic approaches (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20481652%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20481652%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Kian Fan Chung

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20481652%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

author name string

John A Marwick

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20481652%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

publication date

1 May 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20481652%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20481652%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

volume

70

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20481652%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20481652%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

page(s)

929-948

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20481652%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.2165/10898520-000000000-00000

2 February 2020

exact match

0 references

cites work

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12 December 2020

Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2.

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12 December 2020

Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future.

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12 December 2020

p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211.

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12 December 2020

The effects of non-genomic glucocorticoid mechanisms on bodily functions and the central neural system. A critical evaluation of findings.

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12 December 2020

Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma

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12 December 2020

Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways

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12 December 2020

Emerging roles of glucocorticoid receptor phosphorylation in modulating glucocorticoid hormone action in health and disease

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12 December 2020

Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma

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12 December 2020

Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations

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12 December 2020

Oxidative stress causes IL8 promoter hyperacetylation in cystic fibrosis airway cell models

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12 December 2020

Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes

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12 December 2020

A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma

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12 December 2020

Immunology of asthma and chronic obstructive pulmonary disease

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12 December 2020

The cytokine network in asthma and chronic obstructive pulmonary disease

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12 December 2020

Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles.

1 reference

12 December 2020

Global strategy for asthma management and prevention: GINA executive summary.

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12 December 2020

The origin and functions of multiple human glucocorticoid receptor isoforms

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12 December 2020

Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions

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12 December 2020

The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease

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12 December 2020

Bronchial CD8 cell infiltrate and lung function decline in asthma.

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12 December 2020

Differential regulation of the transcriptional activity of the glucocorticoid receptor through site-specific phosphorylation

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12 December 2020

Glucocorticoid receptor alpha and beta in glucocorticoid dependent asthma

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12 December 2020

Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy

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12 December 2020

Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

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12 December 2020

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

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12 December 2020

A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.

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12 December 2020

Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model

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12 December 2020

Effect of High Dose Inhaled Steroid on Cells, Cytokines, and Proteases in Induced Sputum in Chronic Obstructive Pulmonary Disease

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12 December 2020

Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression

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12 December 2020

Effect of N-acetylcysteine on air trapping in COPD: a randomized placebo-controlled study

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12 December 2020

Oxidative stress modulates theophylline effects on steroid responsiveness

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12 December 2020

The human glucocorticoid receptor (hGR) beta isoform suppresses the transcriptional activity of hGRalpha by interfering with formation of active coactivator complexes

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12 December 2020

Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages

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12 December 2020

Ibuprofen therapy for cystic fibrosis lung disease: revisited

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12 December 2020

New molecular targets for the treatment of neutrophilic diseases

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12 December 2020

Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways

1 reference

12 December 2020

Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis.

1 reference

12 December 2020

Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma

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12 December 2020

Corticosteroid resistance in chronic asthma

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12 December 2020

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

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12 December 2020

Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression

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12 December 2020

Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression

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12 December 2020

Association of cystic fibrosis with abnormalities in fatty acid metabolism.

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12 December 2020

The human Mi-2/NuRD complex and gene regulation

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12 December 2020

Oxidants and the pathogenesis of lung diseases

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12 December 2020

Glucocorticoid receptor mRNA levels in bronchial epithelial cells of patients with COPD: influence of glucocorticoids.

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12 December 2020

Dysregulated interleukin-8 secretion and NF-kappaB activity in human cystic fibrosis nasal epithelial cells

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12 December 2020

Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism

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12 December 2020

Glucocorticoid receptor phosphorylation differentially affects target gene expression

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12 December 2020

Molecular mechanisms regulating glucocorticoid sensitivity and resistance

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12 December 2020

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

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12 December 2020

Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.

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12 December 2020

Steroid receptor interactions with heat shock protein and immunophilin chaperones

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12 December 2020

Methodological issues in therapeutic trials of COPD.

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12 December 2020

Airway remodeling and lack of bronchodilator response in steroid-resistant asthma

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12 December 2020

Glucocorticoid resistance in inflammatory diseases.

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12 December 2020

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

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12 December 2020

Mechanisms of the noxious inflammatory cycle in cystic fibrosis

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12 December 2020

Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.

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12 December 2020

Global burden of COPD: risk factors, prevalence, and future trends

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12 December 2020

Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK.

1 reference

12 December 2020

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

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12 December 2020

Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD

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12 December 2020

Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactions

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12 December 2020

Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma

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12 December 2020

High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids

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12 December 2020

Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthma.

1 reference

12 December 2020

Increased glucocorticoid receptor-beta expression, but not decreased histone deacetylase 2, in severe asthma

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12 December 2020

Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration

1 reference

12 December 2020

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

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12 December 2020

Antioxidant therapeutic advances in COPD.

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12 December 2020

Decreased histone deacetylase activity in chronic obstructive pulmonary disease.

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12 December 2020

Methylprednisolone resistance of cystic fibrosis lymphocytes.

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12 December 2020

Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

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12 December 2020

Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft

1 reference

12 December 2020

Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD.

1 reference

12 December 2020

Neutrophilic inflammation in severe persistent asthma

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12 December 2020

Asthma severity is associated with an increase in both blood CXCR3+ and CCR4+ T cells.

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12 December 2020

Kinase inhibitors and airway inflammation.

1 reference

12 December 2020

Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2

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12 December 2020

Fluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitis

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12 December 2020

Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research

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12 December 2020

Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma

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12 December 2020

Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function

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12 December 2020

Inhibition of p38 mitogen activated protein kinase controls airway inflammation in cystic fibrosis

1 reference

12 December 2020

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

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12 December 2020

Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma

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12 December 2020

Differential regulation of cytokine production by PI3Kdelta in human monocytes upon acute and chronic inflammatory conditions

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12 December 2020

Phosphorylation and inhibition of rat glucocorticoid receptor transcriptional activation by glycogen synthase kinase-3 (GSK-3). Species-specific differences between human and rat glucocorticoid receptor signaling as revealed through GSK-3 phosphoryl

1 reference

12 December 2020

Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling

1 reference

12 December 2020

Patients with multiple sclerosis resisted to glucocorticoid therapy: abnormal expression of heat-shock protein 90 in glucocorticoid receptor complex.

1 reference

12 December 2020

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

1 reference

12 December 2020

Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification.

1 reference

12 December 2020

Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease

1 reference

12 December 2020

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

1 reference

12 December 2020

Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs

1 reference

12 December 2020

Oral N-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in rats

1 reference

12 December 2020

Sin3: a flexible regulator of global gene expression and genome stability.

1 reference

12 December 2020

p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation

1 reference

12 December 2020

Assessing the burden of respiratory disease in the UK.

1 reference

12 December 2020

Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression

1 reference

12 December 2020

Role of mRNA expression of transcription factors in glucocorticoid sensitivity of peripheral blood mononuclear cells and disease state in rheumatoid arthritis.

1 reference

12 December 2020

Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice

1 reference

12 December 2020

A reduction state potentiates the glucocorticoid response through receptor protein stabilization

1 reference

12 December 2020

Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma

1 reference

12 December 2020

Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial

1 reference

12 December 2020

Expression of glucocorticoid receptors alpha and beta in steroid sensitive and steroid insensitive interstitial lung diseases.

1 reference

12 December 2020

Loss of CFTR results in reduction of histone deacetylase 2 in airway epithelial cells

1 reference

12 December 2020

Levels changes of blood leukocytes and intracellular signalling pathways in COPD patients with respect to smoking attitude

1 reference

12 December 2020

The nature of small-airway obstruction in chronic obstructive pulmonary disease

1 reference

12 December 2020

Sin meets NuRD and other tails of repression.

1 reference

12 December 2020

Bacterial infection and the pathogenesis of COPD.

1 reference

12 December 2020

Inhibition of glucocorticoid receptor-mediated transcriptional activation by p38 mitogen-activated protein (MAP) kinase

1 reference

12 December 2020

Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage

1 reference

12 December 2020

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosisin Vitro

1 reference

12 December 2020

Antiinflammatory action of glucocorticoids--new mechanisms for old drugs

1 reference

12 December 2020

Asthma and cigarette smoking.

1 reference

12 December 2020

Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages

1 reference

12 December 2020

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction.

1 reference

12 December 2020

1 reference

12 December 2020

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

1 reference

12 December 2020

The p110delta isoform of PI3K differentially regulates beta1 and beta2 integrin-mediated monocyte adhesion and spreading and modulates diapedesis

1 reference

12 December 2020

Phosphoinositide 3-kinase-delta inhibitor reduces vascular permeability in a murine model of asthma.

1 reference

12 December 2020

p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma

1 reference

12 December 2020

Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease

1 reference

12 December 2020

Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients

1 reference

12 December 2020

Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma

1 reference

12 December 2020

Tissue-specific glucocorticoid action: a family affair

1 reference

12 December 2020

Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy.

1 reference

12 December 2020

Human glucocorticoid receptor beta binds RU-486 and is transcriptionally active.

1 reference

12 December 2020

Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma

1 reference

12 December 2020

Inhaled corticosteroids for stable chronic obstructive pulmonary disease

1 reference

12 December 2020

Structural Modifications of Histones and their Possible Role in the Regulation of RNA Synthesis

1 reference

12 December 2020

Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy

1 reference

12 December 2020

Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity

1 reference

12 December 2020

Increased activation of p38 MAPK in COPD

1 reference

12 December 2020

p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment

1 reference

12 December 2020

Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice

1 reference

12 December 2020

The role of chromatin during transcription

1 reference

12 December 2020

Selective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index.

1 reference

12 December 2020

10.2165/10898520-000000000-00000

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20481652%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 February 2020

1003067678

0 references

Fatcat ID

release_bqhw33yhdndrpldkqezzqomyom

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/bqhw33yhdndrpldkqezzqomyom

24 November 2022

mapped directly with Wikidata item

1 reference