(Q37766263)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560993%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

review article

1 reference

title

REVIEW: γ-Secretase inhibitors for the treatment of Alzheimer's disease: The current state (English)

1 reference

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5 February 2020

0 references

1

1 reference

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5 February 2020

Vincenza Frisardi

2

1 reference

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5 February 2020

Bruno Imbimbo

3

1 reference

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5 February 2020

Cristiano Capurso

4

1 reference

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5 February 2020

Daniele Sancarlo

6

1 reference

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5 February 2020

10

Vincenzo Solfrizzi

1 reference

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5 February 2020

7

Davide Seripa

1 reference

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5 February 2020

8

Gianluigi Vendemiale

1 reference

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5 February 2020

author name string

Alberto Pilotto

9

1 reference

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5 February 2020

Giancarlo Logroscino

5

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5 February 2020

publication date

16 June 2010

1 reference

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CNS Neuroscience & Therapeutics

5 February 2020

published in

1 reference

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5 February 2020

volume

16

1 reference

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5 February 2020

issue

5

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5 February 2020

page(s)

272-284

1 reference

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A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase

5 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00164.X

Effectiveness of Cholinesterase Inhibitors and Memantine for Treating Dementia: Evidence Review for a Clinical Practice Guideline

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00164.X

Beyond the neurotransmitter-focused approach in treating Alzheimer's disease: drugs targeting beta-amyloid and tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00164.X

Neuropathology of cognitively normal elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00164.X

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

12 December 2020

Contact-dependent inhibition of cortical neurite growth mediated by notch signaling

1 reference

12 December 2020

APP carboxyl-terminal fragment without or with abeta domain equally induces cytotoxicity in differentiated PC12 cells and cortical neurons.

1 reference

12 December 2020

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

12 December 2020

Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer's disease

1 reference

12 December 2020

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

1 reference

12 December 2020

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

12 December 2020

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

12 December 2020

Presenilins are not required for A beta 42 production in the early secretory pathway.

1 reference

12 December 2020

Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages

1 reference

12 December 2020

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

1 reference

12 December 2020

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

1 reference

12 December 2020

Notch and the immune system

1 reference

12 December 2020

Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations

1 reference

12 December 2020

Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy

1 reference

12 December 2020

Intramembrane proteolysis: theme and variations.

1 reference

12 December 2020

Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

1 reference

12 December 2020

Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro

1 reference

12 December 2020

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

1 reference

12 December 2020

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

1 reference

12 December 2020

Direct regulation of intestinal fate by Notch

1 reference

12 December 2020

Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

1 reference

12 December 2020

Blockade of gamma-secretase activity within the hippocampus enhances long-term memory.

1 reference

12 December 2020

A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage

1 reference

12 December 2020

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

1 reference

12 December 2020

Amyloid beta: the alternate hypothesis

1 reference

12 December 2020

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

1 reference

12 December 2020

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

1 reference

12 December 2020

The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse.

1 reference

12 December 2020

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1 reference

12 December 2020

One hundred years after the discovery of Alzheimer's disease. A turning point for therapy?

1 reference

12 December 2020

Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron

1 reference

12 December 2020

Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-beta peptide

1 reference

12 December 2020

Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase

1 reference

12 December 2020

Recent progress in the medicinal chemistry of gamma-secretase inhibitors

1 reference

12 December 2020

Therapeutic potential of gamma-secretase inhibitors and modulators

1 reference

12 December 2020

The Notch pathway: hair graying and pigment cell homeostasis

1 reference

12 December 2020

Alzheimer disease pathology as a host response

1 reference

12 December 2020

Abeta40 promotes neuronal cell fate in neural progenitor cells

1 reference

12 December 2020

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

12 December 2020

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

1 reference

12 December 2020

Inhibition and modulation of gamma-secretase for Alzheimer's disease

1 reference

12 December 2020

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

1 reference

12 December 2020

Amyloid-beta immunisation for Alzheimer's disease

1 reference

12 December 2020

Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition

1 reference

12 December 2020

Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease

1 reference

12 December 2020

Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis

1 reference

12 December 2020

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

1 reference

12 December 2020

Mixed results for disease-modification strategies for Alzheimer's disease.

1 reference

12 December 2020

A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system

1 reference

12 December 2020

Semagacestat, a gamma-secretase inhibitor for the potential treatment of Alzheimer's disease.

1 reference

12 December 2020

Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators.

1 reference

12 December 2020

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease

1 reference

12 December 2020

Towards disease-modifying treatment of Alzheimer's disease: drugs targeting beta-amyloid.

1 reference

12 December 2020

gamma-Secretase as a therapeutic target in Alzheimer's disease

1 reference

12 December 2020

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

12 December 2020

10.1111/J.1755-5949.2010.00164.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560993%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560993%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

20560993

1 reference