(Q37772498)

22 August 2017

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title

Advances and perspectives from genetic research: development of biological markers in Alzheimer's disease (English)

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22 August 2017

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4

Harald Hampel

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22 August 2017

3

John Hardy

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22 August 2017

2

Dan Rujescu

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22 August 2017

Thomas Zetzsche

1

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PubMed ID

20629514

22 August 2017

language of work or name

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1 July 2010

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Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

22 August 2017

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22 August 2017

10

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22 August 2017

667-690

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22 August 2017

5

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LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease

22 August 2017

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Genetics of Alzheimer's disease: recent advances

21 January 2018

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Analysis of the episodic memory deficit in early Alzheimer's disease: evidence from the doors and people test.

21 January 2018

1 reference

Neuropsychological patterns and language deficits in 20 consecutive cases of autopsy-confirmed Alzheimer's disease

21 January 2018

1 reference

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

21 January 2018

1 reference

Amyloid precursor protein transgenic mouse models and Alzheimer's disease: understanding the paradigms, limitations, and contributions

21 January 2018

1 reference

Mouse models of Alzheimer's disease: The long and filamentous road

21 January 2018

1 reference

Elderly patients with dementia-related symptoms of severe agitation and aggression: consensus statement on treatment options, clinical trials methodology, and policy

21 January 2018

1 reference

Disease-modifying therapies in Alzheimer's disease

21 January 2018

1 reference

Genome-wide association studies in Alzheimer's disease

21 January 2018

1 reference

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

1 reference

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

A familial Alzheimer's disease locus on chromosome 1.

21 January 2018

1 reference

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

21 January 2018

1 reference

Molecular diagnosis of autosomal dominant early onset Alzheimer's disease: an update

21 January 2018

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Pharmacogenomics and therapeutic prospects in dementia

21 January 2018

1 reference

Heritability for Alzheimer's disease: the study of dementia in Swedish twins

21 January 2018

1 reference

Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study

21 January 2018

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Alzheimer's disease in twins

21 January 2018

1 reference

Complete genomic screen in late-onset familial Alzheimer's disease.

21 January 2018

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A full genome scan for late onset Alzheimer's disease.

21 January 2018

1 reference

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

21 January 2018

1 reference

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

1 reference

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

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Apolipoprotein E and Alzheimer's disease. The tip of the susceptibility iceberg.

21 January 2018

1 reference

The role of apolipoprotein E in Alzheimer's disease

21 January 2018

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Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

21 January 2018

1 reference

Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center

21 January 2018

1 reference

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

21 January 2018

1 reference

Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease

21 January 2018

1 reference

Vascular disease and risk factors, rate of progression, and survival in Alzheimer's disease.

21 January 2018

1 reference

Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer's disease?

21 January 2018

1 reference

The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects.

21 January 2018

1 reference

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

21 January 2018

1 reference

GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers

21 January 2018

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Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.

21 January 2018

1 reference

Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.

21 January 2018

1 reference

Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease

21 January 2018

1 reference

Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease

21 January 2018

1 reference

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

21 January 2018

1 reference

Genetics of Alzheimer disease in the pre- and post-GWAS era

21 January 2018

1 reference

A genome-wide association study for late-onset Alzheimer's disease using DNA pooling

21 January 2018

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Examination of the current top candidate genes for AD in a genome-wide association study

21 January 2018

1 reference

Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling

21 January 2018

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Association study of the GAB2 gene with the risk of developing Alzheimer's disease.

21 January 2018

1 reference

Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia

21 January 2018

1 reference

GAB2 is not associated with late-onset Alzheimer's disease in Japanese

21 January 2018

1 reference

The GAB2 gene and the risk of Alzheimer's disease: replication and meta-analysis.

21 January 2018

1 reference

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

21 January 2018

1 reference

Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein

21 January 2018

1 reference

SORL1 variants and risk of late-onset Alzheimer's disease

21 January 2018

1 reference

The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort

21 January 2018

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SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population

21 January 2018

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No association of SORL1 SNPs with Alzheimer's disease.

21 January 2018

1 reference

Alzheimer's disease: advances in trafficking

21 January 2018

1 reference

Reduction of sortilin-1 in Alzheimer hippocampus and in cytokine-stressed human brain cells

21 January 2018

1 reference

Neuronal LR11/sorLA expression is reduced in mild cognitive impairment

21 January 2018

1 reference

The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease

21 January 2018

1 reference

Galanin hyperinnervates surviving neurons of the human basal nucleus of Meynert in dementias of Alzheimer's and Parkinson's disease: a hypothesis for the role of galanin in accentuating cholinergic dysfunction in dementia.

21 January 2018

1 reference

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

21 January 2018

1 reference

Retinoid receptors, transporters, and metabolizers as therapeutic targets in late onset Alzheimer disease

21 January 2018

1 reference

Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain

21 January 2018

1 reference

Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1

21 January 2018

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Oncogenes and signal transduction

21 January 2018

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Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

Ram rete testis fluid contains a protein (clusterin) which influences cell-cell interactions in vitro

21 January 2018

1 reference

Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat.

21 January 2018

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Clusterin: a forgotten player in Alzheimer's disease

21 January 2018

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Meta-analysis of linkage studies for Alzheimer's disease--a web resource

21 January 2018

1 reference

Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus

21 January 2018

1 reference

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

21 January 2018

1 reference

Role of Genes and Environments for Explaining Alzheimer Disease

21 January 2018

1 reference

Genomic DNA methylation: the mark and its mediators

21 January 2018

1 reference

Chromatin modifications and their function

21 January 2018

1 reference

The role of chromatin during transcription

21 January 2018

1 reference

Epigenetics, oxidative stress, and Alzheimer disease

21 January 2018

1 reference

Dynamic reprogramming of DNA methylation in the early mouse embryo.

21 January 2018

1 reference

Epigenetic dysregulation in cognitive disorders.

21 January 2018

1 reference

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

21 January 2018

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Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration.

21 January 2018

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Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

21 January 2018

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Recovery of learning and memory is associated with chromatin remodelling

21 January 2018

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Presenilin 1 gene silencing by S‐adenosylmethionine: a treatment for Alzheimer disease?

21 January 2018

1 reference

Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD.

21 January 2018

1 reference

Age-specific epigenetic drift in late-onset Alzheimer's disease

21 January 2018

1 reference

Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex.

21 January 2018

1 reference

PCR amplification in bisulfite methylcytosine mapping in the GC-rich promoter region of amyloid precursor protein gene in autopsy human brain.

21 January 2018

1 reference

S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production.

21 January 2018

1 reference

Use of genetic variation as biomarkers for Alzheimer's disease

21 January 2018

1 reference

Multiple threshold model for the onset of Alzheimer's disease in the NAS-NRC twin panel

21 January 2018

1 reference

The endophenotype concept in psychiatry: etymology and strategic intentions

21 January 2018

1 reference

Genetic Theorizing and Schizophrenia

21 January 2018

1 reference

APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study.

21 January 2018

1 reference

Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease

21 January 2018

1 reference

Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease.

21 January 2018

1 reference

Apolipoprotein E type 4 allele and Alzheimer's disease: effect on age at onset and relative risk in different age groups.

21 January 2018

1 reference

Apolipoprotein E polymorphism and Alzheimer's disease.

21 January 2018

1 reference

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

21 January 2018

1 reference

Association of SORL1 gene variants with Alzheimer's disease

21 January 2018

1 reference

Sequence variation in SORL1 and dementia risk in Swedes

21 January 2018

1 reference

Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory Study

21 January 2018

1 reference

APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease

21 January 2018

1 reference

APOE status and its association to learning and memory performance in middle aged and older Norwegians seeking assessment for memory deficits

21 January 2018

1 reference

5-HT2A and 5-HT2C receptor polymorphisms and psychopathology in late onset Alzheimer's disease.

21 January 2018

1 reference

Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease

21 January 2018

1 reference

Psychotic symptoms in Alzheimer's disease are not influenced by polymorphic variation at the dopamine receptor DRD3 gene

21 January 2018

1 reference

Neurotransmitter deficits in behavioural and psychological symptoms of Alzheimer's disease

21 January 2018

1 reference

Role of serotonin transporter polymorphisms in the behavioural and psychological symptoms in probable Alzheimer disease patients

21 January 2018

1 reference

Role of 5HT 2A and 5HT 2C polymorphisms in behavioural and psychological symptoms of Alzheimer's disease

21 January 2018

1 reference

Apolipoprotein E e4 allele influences aggressive behaviour in Alzheimer's disease

21 January 2018

1 reference

The effect of the apolipoprotein E gene polymorphisms and haplotypes on behavioural and psychological symptoms in probable Alzheimer's disease

21 January 2018

1 reference

Genotype and phenotype in Alzheimer's disease

21 January 2018

1 reference

Neurobiology and genetics of behavioural syndromes of Alzheimer's disease

21 January 2018

1 reference

Investigation of dopamine receptors in susceptibility to behavioural and psychological symptoms in Alzheimer's disease

21 January 2018

1 reference

Association between 5-HT(2A) receptor polymorphism and psychotic symptoms in Alzheimer's disease

21 January 2018

1 reference

Serotoninergic polymorphisms (5-HTTLPR and 5-HT2A): association studies with psychosis in Alzheimer disease.

21 January 2018

1 reference

5-HT2A T102C receptor polymorphism and neuropsychiatric symptoms in Alzheimer's disease.

21 January 2018

1 reference

Serotonergic system genes in psychosis of Alzheimer dementia: meta-analysis

21 January 2018

1 reference

Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation

21 January 2018

1 reference

Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease

21 January 2018

1 reference

Core candidate neurochemical and imaging biomarkers of Alzheimer's disease

21 January 2018

1 reference

CSF biomarkers: pinpointing Alzheimer pathogenesis

21 January 2018

1 reference

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

21 January 2018

1 reference

Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's disease.

21 January 2018

1 reference

Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease

21 January 2018

1 reference

CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI.

21 January 2018

1 reference

The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease

21 January 2018

1 reference

High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype.

21 January 2018

1 reference

Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer's disease.

21 January 2018

1 reference

Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele

21 January 2018

1 reference

Association of CSF apolipoprotein E, Abeta42 and cognition in Alzheimer's disease.

21 January 2018

1 reference

Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment

21 January 2018

1 reference

Differential CSF biomarker levels in APOE-epsilon4-positive and -negative patients with memory impairment.

21 January 2018

1 reference

Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition.

21 January 2018

1 reference

Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints

21 January 2018

1 reference

APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

21 January 2018

1 reference

Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease.

21 January 2018

1 reference

Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta

21 January 2018

1 reference

ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala.

21 January 2018

1 reference

Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome

21 January 2018

1 reference

Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

21 January 2018

1 reference

Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

21 January 2018

1 reference

Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

21 January 2018

1 reference

No difference in cerebral glucose metabolism in patients with Alzheimer disease and differing apolipoprotein E genotypes.

21 January 2018

1 reference

APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging

21 January 2018

1 reference

Single photon emission computed tomography and apolipoprotein E in Alzheimer's disease: impact of the epsilon4 allele on regional cerebral blood flow.

21 January 2018

1 reference

APOE-4 genotype and neurophysiological vulnerability to Alzheimer's and cognitive aging

21 January 2018

1 reference

Patterns of brain activation in people at risk for Alzheimer's disease.

21 January 2018

1 reference

Amyloid imaging in Alzheimer's disease.

21 January 2018

1 reference

PET of brain amyloid and tau in mild cognitive impairment.

21 January 2018

1 reference

Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia

21 January 2018

1 reference

Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease.

21 January 2018

1 reference

Imaging beta-amyloid burden in aging and dementia.

21 January 2018

1 reference

Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

21 January 2018

1 reference

Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup

21 January 2018

1 reference

Novel MRI techniques in the assessment of dementia

21 January 2018

1 reference

Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory

21 January 2018

1 reference

Hippocampal volumes are important predictors for memory function in elderly women

21 January 2018

1 reference

Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults

21 January 2018

1 reference

Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease.

21 January 2018

1 reference

Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease.

21 January 2018

1 reference

Accelerated hippocampal atrophy in Alzheimer's disease with apolipoprotein E epsilon4 allele.

21 January 2018

1 reference

MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers

21 January 2018

1 reference

Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment

21 January 2018

1 reference

Imaging studies and APOE genotype in persons at risk for Alzheimer's disease

21 January 2018

1 reference

The medical and economic roles of pipeline pharmacogenetics: Alzheimer's disease as a model of efficacy and HLA-B(*)5701 as a model of safety

21 January 2018

1 reference

A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression

21 January 2018

1 reference

Pharmacogenomics and treatment for dementia induced by Alzheimer's disease

21 January 2018

1 reference

The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects

21 January 2018

1 reference

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

21 January 2018

1 reference

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

21 January 2018

1 reference

Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs

21 January 2018

1 reference

Short interfering RNA (siRNA) as a novel therapeutic

21 January 2018

1 reference

BACE1 Suppression by RNA Interference in Primary Cortical Neurons

21 January 2018

1 reference

High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

21 January 2018

1 reference

RNAi silencing in mouse models of neurodegenerative diseases

21 January 2018

1 reference

RNA interference as a tool for Alzheimer's disease therapy

21 January 2018

1 reference

The pharmacogenomics of Alzheimer's disease

21 January 2018

1 reference

Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer's disease

21 January 2018

1 reference

Apolipoprotein E as a target for developing new therapeutics for Alzheimer's disease based on studies from protein, RNA, and regulatory region of the gene

21 January 2018

1 reference

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

21 January 2018

1 reference

Positron emission tomography imaging in dementia.

21 January 2018

1 reference

Amyloid plaque imaging in vivo: current achievement and future prospects.

21 January 2018

1 reference

Biological marker candidates of Alzheimer's disease in blood, plasma, and serum.

21 January 2018

1 reference

Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants

21 January 2018

1 reference

Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression: Characterization of Intracellular Mediators and Potential Genomic Target Sites

21 January 2018

1 reference

Clinical and pathological correlates of apolipoprotein E ?4 in Alzheimer's disease

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/ERM.10.48

1 reference

22 August 2017

1 reference

PubMed ID

20629514