(Q37777490)

23 August 2017

1 reference

title

The molecular basis of bisphosphonate activity: a preclinical perspective (English)

1 reference

23 August 2017

The Molecular Basis of Bisphosphonate Activity: A Preclinical Perspective (English)

1 reference

https://api.crossref.org/works/10.1053/J.SEMINONCOL.2010.06.003

16 June 2024

2

Philippe Clézardin

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20682369

16 June 2024

author name string

Jonathan Green

1

1 reference

23 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20682369

16 June 2024

publication date

1 June 2010

1 reference

full work available at URL

23 August 2017

https://api.elsevier.com/content/article/PII:S0093775410000825?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1053/J.SEMINONCOL.2010.06.003

https://api.elsevier.com/content/article/PII:S0093775410000825?httpAccept=text/plain

16 June 2024

1 reference

https://api.crossref.org/works/10.1053/J.SEMINONCOL.2010.06.003

16 June 2024

1 reference

23 August 2017

volume

37 Suppl 1

1 reference

23 August 2017

page(s)

S3-11

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Development of bisphosphonates

23 August 2017

cites work

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1 reference

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Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo

16 June 2024

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Inhibition by two diphosphonates of bone lysis in tumor-conditioned media

16 June 2024

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The effects of dichloromethylene diphosphonate on hypercalcemia and other parameters of the humoral hypercalcemia of malignancy in the rat leydig cell tumor

16 June 2024

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Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy

16 June 2024

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Thermodynamics of bisphosphonates binding to human bone: a two-site model

16 June 2024

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Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones

16 June 2024

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Enhanced ability of dendritic cells to stimulate innate and adaptive immunity on short-term incubation with zoledronic acid

16 June 2024

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Specific requirements for Vgamma9Vdelta2 T cell stimulation by a natural adenylated phosphoantigen.

16 June 2024

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Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells.

16 June 2024

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Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis

16 June 2024

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Trafficking of Matrix Collagens Through Bone-Resorbing Osteoclasts

16 June 2024

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Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.

16 June 2024

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Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

16 June 2024

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A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates.

16 June 2024

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Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

16 June 2024

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The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

16 June 2024

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Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

16 June 2024

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Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.

16 June 2024

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Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells

16 June 2024

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Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.

16 June 2024

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Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

16 June 2024

29

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Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro

16 June 2024

30

1 reference

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Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells

16 June 2024

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Regulation of osteoclast differentiation and function by receptor activator of NFkB ligand and osteoprotegerin.

16 June 2024

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Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway

16 June 2024

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Investigating the interaction between osteoprotegerin and receptor activator of NF-kappaB or tumor necrosis factor-related apoptosis-inducing ligand: evidence for a pivotal role for osteoprotegerin in regulating two distinct pathways

16 June 2024

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The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE).

16 June 2024

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Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts.

16 June 2024

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Zoledronic acid induces apoptosis and changes the TRAIL/OPG ratio in breast cancer cells.

16 June 2024

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Aberrant rel/nfkb genes and activity in human cancer

16 June 2024

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Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis.

16 June 2024

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16 June 2024

TGF-beta and cancer

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Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection.

16 June 2024

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Bisphosphonates suppress insulin-like growth factor 1-induced angiogenesis via the HIF-1alpha/VEGF signaling pathways in human breast cancer cells

16 June 2024

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Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells

16 June 2024

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Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro

16 June 2024

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Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes

16 June 2024

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Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.

16 June 2024

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Pamidronate decreases tumor-induced osteoclastogenesis in osteopetrotic mice

16 June 2024

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Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: the role of protein geranylgeranylation in the action of nitrogen-containing bisphosphona

16 June 2024

51

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Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs

16 June 2024

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Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo

16 June 2024

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The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells

16 June 2024

54

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Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model.

16 June 2024

55

1 reference

https://api.crossref.org/works/10.1053/J.SEMINONCOL.2010.06.003

The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway

16 June 2024

57

1 reference

https://api.crossref.org/works/10.1053/J.SEMINONCOL.2010.06.003

Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells

16 June 2024

58

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https://api.crossref.org/works/10.1053/J.SEMINONCOL.2010.06.003

The plasticity of gamma delta T cells: innate immunity, antigen presentation and new immunotherapy

16 June 2024

59

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Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens

16 June 2024

60

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https://api.crossref.org/works/10.1053/J.SEMINONCOL.2010.06.003

Cytotoxic effects of gammadelta T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy.

16 June 2024

61

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Intravesical administration of gammadelta T cells successfully prevents the growth of bladder cancer in the murine model

16 June 2024

62

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Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP.

16 June 2024

63

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16 June 2024

Identifiers

1 reference

23 August 2017

1 reference