(Q37801346)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957626%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo (English)

1 reference

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15 February 2020

1

1 reference

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15 February 2020

author name string

Sean M Post

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957626%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Guillermina Lozano

series ordinal

3

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15 February 2020

publication date

18 October 2010

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15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957626%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

volume

223

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957626%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

issue

2

1 reference

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15 February 2020

page(s)

127-136

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Intrinsic tumour suppression

15 February 2020

cites work

1 reference

Cell-cycle checkpoints and cancer

21 January 2018

1 reference

The role of p53 in determining sensitivity to radiotherapy

21 January 2018

1 reference

Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis

21 January 2018

1 reference

Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

21 January 2018

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Transcriptional control of human p53-regulated genes

21 January 2018

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Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice

21 January 2018

1 reference

Tissue-specific p53 responses to ionizing radiation and their genetic modification: the key to tissue-specific tumour susceptibility?

21 January 2018

1 reference

Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo.

21 January 2018

1 reference

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

1 reference

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

21 January 2018

1 reference

Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.

21 January 2018

1 reference

Live or let die: the cell's response to p53

21 January 2018

1 reference

Outcomes of p53 activation--spoilt for choice

21 January 2018

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Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

21 January 2018

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Life and death decisions by the E2F transcription factors

21 January 2018

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The signals and pathways activating cellular senescence

21 January 2018

1 reference

p53 and E2f: partners in life and death

21 January 2018

1 reference

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

21 January 2018

1 reference

The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53.

21 January 2018

1 reference

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

21 January 2018

1 reference

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development

21 January 2018

1 reference

The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival

21 January 2018

1 reference

Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

21 January 2018

1 reference

Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.

21 January 2018

1 reference

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

21 January 2018

1 reference

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

21 January 2018

1 reference

Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development

21 January 2018

1 reference

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

p21 is a universal inhibitor of cyclin kinases

21 January 2018

1 reference

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

21 January 2018

1 reference

Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

21 January 2018

1 reference

Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

21 January 2018

1 reference

p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes

21 January 2018

1 reference

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

21 January 2018

1 reference

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

The RB and p53 pathways in cancer

21 January 2018

1 reference

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

21 January 2018

1 reference

Apoptotic cell death induced by c-myc is inhibited by bcl-2.

21 January 2018

1 reference

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

21 January 2018

1 reference

Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

21 January 2018

1 reference

Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS.

21 January 2018

1 reference

Acute overexpression of Myc in intestinal epithelium recapitulates some but not all the changes elicited by Wnt/beta-catenin pathway activation

21 January 2018

1 reference

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

21 January 2018

1 reference

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

21 January 2018

1 reference

Cellular senescence as a tumor-suppressor mechanism

21 January 2018

1 reference

Senescence in tumours: evidence from mice and humans

21 January 2018

1 reference

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

21 January 2018

1 reference

Cellular senescence: mitotic clock or culture shock?

21 January 2018

1 reference

Hallmarks of senescence in carcinogenesis and cancer therapy

21 January 2018

1 reference

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

Absence of senescence-associated beta-galactosidase activity in human melanocytic nevi in vivo

21 January 2018

1 reference

Senescence-associated beta-galactosidase is lysosomal beta-galactosidase

21 January 2018

1 reference

The power and the promise of oncogene-induced senescence markers.

21 January 2018

1 reference

Tumour biology: senescence in premalignant tumours

21 January 2018

1 reference

Cellular senescence in aging primates.

21 January 2018

1 reference

Accumulation of senescent cells in mitotic tissue of aging primates

21 January 2018

1 reference

p16INK4A is a robust in vivo biomarker of cellular aging in human skin.

21 January 2018

1 reference

APC expression in normal human tissues

21 January 2018

1 reference

Total body irradiation selectively induces murine hematopoietic stem cell senescence

21 January 2018

1 reference

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

21 January 2018

1 reference

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts

21 January 2018

1 reference

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

21 January 2018

1 reference

Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence

21 January 2018

1 reference

Short telomeres limit tumor progression in vivo by inducing senescence

21 January 2018

1 reference

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

21 January 2018

1 reference

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

21 January 2018

1 reference

A negative feedback signaling network underlies oncogene-induced senescence

21 January 2018

1 reference

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

High frequency of BRAF mutations in nevi

21 January 2018

1 reference

BRAFE600-associated senescence-like cell cycle arrest of human naevi

21 January 2018

1 reference

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

21 January 2018

1 reference

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

21 January 2018

1 reference

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

1 reference

Chemokine signaling via the CXCR2 receptor reinforces senescence

21 January 2018

1 reference

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

21 January 2018

1 reference

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

21 January 2018

1 reference

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

21 January 2018

1 reference

Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells

21 January 2018

1 reference

Reversal of human cellular senescence: roles of the p53 and p16 pathways

21 January 2018

1 reference

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

21 January 2018

1 reference

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

21 January 2018

1 reference

Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

21 January 2018

1 reference

Different impact of p53 and p21 on the radiation response of mouse tissues

21 January 2018

1 reference

Myc lacks E2F1's ability to suppress skin carcinogenesis

21 January 2018

1 reference

Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis

21 January 2018

1 reference

Oncogenic Braf induces melanocyte senescence and melanoma in mice

21 January 2018

1 reference

Tumour biology: Policing of oncogene activity by p53

21 January 2018

1 reference