(Q37801565)

23 August 2017

title

Aging and TOR: interwoven in the fabric of life (English)

1 reference

23 August 2017

Zelton Dave Sharp

1

1 reference

23 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20960025

6 August 2024

publication date

21 October 2010

1 reference

full work available at URL

23 August 2017

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114916

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20960025

https://europepmc.org/articles/PMC11114916

6 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20960025

https://europepmc.org/articles/PMC11114916?pdf=render

6 August 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20960025

https://doi.org/10.1007/s00018-010-0542-0

6 August 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20960025

http://link.springer.com/content/pdf/10.1007/s00018-010-0542-0.pdf

6 August 2024

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1007/S00018-010-0542-0

http://link.springer.com/article/10.1007/s00018-010-0542-0/fulltext.html

6 August 2024

1 reference

https://api.crossref.org/works/10.1007/S00018-010-0542-0

http://link.springer.com/content/pdf/10.1007/s00018-010-0542-0

6 August 2024

1 reference

https://api.crossref.org/works/10.1007/S00018-010-0542-0

Cellular and Molecular Life Sciences

6 August 2024

published in

1 reference

23 August 2017

volume

68

1 reference

23 August 2017

issue

4

1 reference

23 August 2017

page(s)

587-597

1 reference

Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation.

23 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Pleiotropy, Natural Selection, and the Evolution of Senescence

21 January 2018

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The role of mTOR signaling in controlling mammalian life span: what a fungicide teaches us about longevity

21 January 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

21 January 2018

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21 January 2018

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Regulation of the aging process by autophagy

21 January 2018

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An emerging role of mTOR in lipid biosynthesis.

21 January 2018

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mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

21 January 2018

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Rapamycin and quasi-programmed aging: four years later

21 January 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

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Regulation of TORC1 by Rag GTPases in nutrient response

21 January 2018

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

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Rapamycin: the cure for all that ails

21 January 2018

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Extending healthy life span--from yeast to humans

21 January 2018

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Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

21 January 2018

1 reference

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Extension of chronological life span in yeast by decreased TOR pathway signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis

21 January 2018

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Regulation of longevity and stress resistance by Sch9 in yeast

21 January 2018

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The enigmatic role of Sir2 in aging

21 January 2018

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Recent developments in yeast aging

21 January 2018

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Protein translation, 2007.

21 January 2018

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Rethinking the mitochondrial theory of aging: the role of mitochondrial gene expression in lifespan determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Genetics: influence of TOR kinase on lifespan in C. elegans

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

21 January 2018

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The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging.

21 January 2018

1 reference

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eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

21 January 2018

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Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

21 January 2018

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A systematic RNAi screen for longevity genes in C. elegans

21 January 2018

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Aging and survival: the genetics of life span extension by dietary restriction.

21 January 2018

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DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs

21 January 2018

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

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4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

21 January 2018

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Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response

21 January 2018

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21 January 2018

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21 January 2018

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

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Overview of caloric restriction and ageing

21 January 2018

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Genetic mouse models of extended lifespan

21 January 2018

1 reference

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Extending the lifespan of long-lived mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Functionally significant insulin-like growth factor I receptor mutations in centenarians

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Caloric restriction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Effect of calorie restriction with or without exercise on body composition and fat distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Caloric restriction delays disease onset and mortality in rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Recent advances in vertebrate aging research 2009.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Reproduction and aging in marmosets and tamarins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

The anabolic actions of growth hormone and thyroxine on protein metabolism in Snell dwarf and normal mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Translational regulation of GCN4 and the general amino acid control of yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

TOR modulates GCN4-dependent expression of genes turned on by nitrogen limitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Autoregulation in the biosynthesis of ribosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Metformin slows down aging and extends life span of female SHR mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Rapamycin extends maximal lifespan in cancer-prone mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Cancer and aging: more puzzles, more promises?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Metformin supplementation and life span in Fischer-344 rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Dietary restriction and aging, 2009.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

mTOR--beyond transplantation

21 January 2018

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Dysregulation of the TSC-mTOR pathway in human disease

21 January 2018

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mTOR, translational control and human disease.

21 January 2018

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Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

21 January 2018

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mTOR regulates memory CD8 T-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Mammalian target of rapamycin: a new molecular target for breast cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Targeting the mTOR pathway using deforolimus in cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

The pharmacology of mTOR inhibition

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-010-0542-0

Targeting mTOR: something old, something new.

21 January 2018

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Stress and mTORture signaling

21 January 2018

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A mechanism for asymmetric segregation of age during yeast budding

21 January 2018

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12 December 2020

Akt/PKB and p38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers

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12 December 2020

Replicative senescence of human fibroblast-like cells in culture

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12 December 2020

The molecular target of rapamycin (mTOR) as a therapeutic target against cancer

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12 December 2020

Caenorhabditis elegans 2007: the premier model for the study of aging

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12 December 2020

Cellular growth in organs of dwarf mice during treatment with growth hormone, thyroxine and plasma fractions containing somatomedin activity

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12 December 2020

Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice

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12 December 2020

TOR and aging: less is more

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12 December 2020

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

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12 December 2020

Anti-tumor action of dietary restriction is lesion-dependent in male Fischer 344 rats

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12 December 2020

Calorie restriction and aging: the ultimate "cleansing diet"

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12 December 2020

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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12 December 2020

Study of ribosomal level in the liver of the normal and dwarf mouse

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12 December 2020

Deforolimus (AP23573) a novel mTOR inhibitor in clinical development

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12 December 2020

Normal assembly of 60 S ribosomal subunits is required for the signaling in response to a secretory defect in Saccharomyces cerevisiae

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12 December 2020

Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity

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12 December 2020

Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats

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12 December 2020

Lysosomal Rag-ulation of mTOR complex 1 activity

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12 December 2020

Growth hormone effects on RNA and protein synthesis in liver

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12 December 2020

Archiv für Geschwulstforschung

97

48

1

VM Dilman

1978

1 reference

https://api.crossref.org/works/10.1007/S00018-010-0542-0

6 August 2024

Identifiers

1 reference

National Center for Biotechnology Information

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20960025

6 August 2024

1 reference