(Q37810229)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21083240%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes (English)

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16 January 2020

6

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16 January 2020

Hans H. Maurer

4

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16 January 2020

author name string

Andy Zöllner

1

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16 January 2020

Daniela Buchheit

2

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16 January 2020

Markus R Meyer

3

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16 January 2020

Frank T Peters

5

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16 January 2020

publication date

1 July 2010

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16 January 2020

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16 January 2020

volume

2

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16 January 2020

issue

7

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16 January 2020

page(s)

1277-1290

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Cytochromes P450 as versatile biocatalysts

16 January 2020

cites work

1 reference

Cytochrome P450: what have we learned and what are the future issues?

21 January 2018

1 reference

Cytochrome P450 systems--biological variations of electron transport chains.

21 January 2018

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The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis

21 January 2018

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Characterization of orphan human cytochromes P450.

21 January 2018

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Heme-iron oxygenases: powerful industrial biocatalysts?

21 January 2018

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Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli

21 January 2018

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Functional expression and characterisation of human cytochrome P45017alpha in Pichia pastoris.

21 January 2018

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The pivotal role of hepatocytes in drug discovery

21 January 2018

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DNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment

21 January 2018

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Biotechnological synthesis of drug metabolites using human cytochrome P450 isozymes heterologously expressed in fission yeast

21 January 2018

1 reference

Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5.

21 January 2018

1 reference

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

21 January 2018

1 reference

Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli

21 January 2018

1 reference

Functional expression of human cytochrome P450 enzymes in Escherichia coli

21 January 2018

1 reference

Biocatalytic production of perillyl alcohol from limonene by using a novel Mycobacterium sp. cytochrome P450 alkane hydroxylase expressed in Pseudomonas putida

21 January 2018

1 reference

Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase

21 January 2018

1 reference

Bioreactor systems in drug metabolism: synthesis of cytochrome P450-generated metabolites.

21 January 2018

1 reference

The development of an efficient system for heterologous expression of cytochrome P450s in Escherichia coli using hemA gene co-expression

21 January 2018

1 reference

Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES.

21 January 2018

1 reference

Purification and functional characterization of human 11beta hydroxylase expressed in Escherichia coli.

21 January 2018

1 reference

Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450.

21 January 2018

1 reference

Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1.

21 January 2018

1 reference

Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5.

21 January 2018

1 reference

21 January 2018

1 reference

Genome sequence of the recombinant protein production host Pichia pastoris

21 January 2018

1 reference

Heterologous protein expression in the methylotrophic yeast Pichia pastoris

21 January 2018

1 reference

Production of recombinant proteins in fermenter cultures of the yeast Pichia pastoris

21 January 2018

1 reference

Use of fission yeast heterologously expressing human cytochrome P450 2B6 in biotechnological synthesis of the designer drug metabolite N-(1-phenylcyclohexyl)-2-hydroxyethanamine.

21 January 2018

1 reference

Total biosynthesis of hydrocortisone from a simple carbon source in yeast

21 January 2018

1 reference

Efficient conversion of 11-deoxycortisol to cortisol (hydrocortisone) by recombinant fission yeast Schizosaccharomyces pombe.

21 January 2018

1 reference

Biotechnological synthesis of the designer drug metabolite 4'-hydroxymethyl-alpha-pyrrolidinohexanophenone in fission yeast heterologously expressing human cytochrome P450 2D6--a versatile alternative to multistep chemical synthesis

21 January 2018

1 reference

Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid.

21 January 2018

1 reference

CYP21-catalyzed production of the long-term urinary metandienone metabolite 17beta-hydroxymethyl-17 alpha-methyl-18-norandrosta-1,4,13-trien-3-one: a contribution to the fight against doping.

21 January 2018

1 reference

Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli.

21 January 2018

1 reference

Engineering Escherichia coli for production of functionalized terpenoids using plant P450s

21 January 2018

1 reference

Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol

21 January 2018

1 reference

Asymmetric ketone reduction with immobilized yeast in hexane: biocatalyst deactivation and regeneration

21 January 2018

1 reference

Biocatalytical production of (5S)-hydroxy-2-hexanone

21 January 2018

1 reference

Biocatalytic asymmetric hydrogen transfer employing Rhodococcus ruber DSM 44541.

21 January 2018

1 reference

On the organic solvent and thermostability of the biocatalytic redox system of Rhodococcus ruber DSM 44541.

21 January 2018

1 reference

Synthesis of ethyl (R)-4-chloro-3-hydroxybutanoate with recombinant Escherichia coli cells expressing (S)-specific secondary alcohol dehydrogenase

21 January 2018

1 reference

Synthesis of (R)-1,3-butanediol by enantioselective oxidation using whole recombinant Escherichia coli cells expressing (S)-specific secondary alcohol dehydrogenase

21 January 2018

1 reference

Enantioselective reduction of carbonyl compounds by whole-cell biotransformation, combining a formate dehydrogenase and a (R)-specific alcohol dehydrogenase

21 January 2018

1 reference

Improved synthesis of chiral alcohols with Escherichia coli cells co-expressing pyridine nucleotide transhydrogenase, NADP+-dependent alcohol dehydrogenase and NAD+-dependent formate dehydrogenase

21 January 2018

1 reference

Overcoming the thermodynamic limitation in asymmetric hydrogen transfer reactions catalyzed by whole cells.

21 January 2018

1 reference

Engineering the Pichia pastoris methanol oxidation pathway for improved NADH regeneration during whole-cell biotransformation.

21 January 2018

1 reference

Biotransformation of benzaldehyde by Saccharomyces cerevisiae: characterization of the fermentation and toxicity effects of substrates and products.

21 January 2018

1 reference

Epoxide hydrolase activity of Streptomyces strains

21 January 2018

1 reference

Epoxide hydrolase-catalyzed resolution of ethyl 3-phenylglycidate using whole cells of Pseudomonas sp.

21 January 2018

1 reference

Biocatalytic resolution of glycidyl aryl ethers by Trichosporon loubierii : cell/substrate ratio influences the optical purity of (R) - epoxides

21 January 2018

1 reference

Novel microbial epoxide hydrolases for biohydrolysis of glycidyl derivatives

21 January 2018

1 reference

Enzymatic resolution of racemic phenyloxirane by a novel epoxide hydrolase from Aspergillus niger SQ-6 and its fed-batch fermentation

21 January 2018

1 reference

Cloning of an epoxide hydrolase-encoding gene from Rhodotorula mucilaginosa and functional expression in Yarrowia lipolytica

21 January 2018

1 reference

Screening enantioselective epoxide hydrolase activities from marine microorganisms: detection of activities in Erythrobacter spp.

21 January 2018

1 reference

Flavin-containing monooxygenases: mutations, disease and drug response

21 January 2018

1 reference

Pharmacogenetics of phase I and phase II drug metabolism

21 January 2018

1 reference

Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification

21 January 2018

1 reference

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

21 January 2018

1 reference

Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily

21 January 2018

1 reference

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

21 January 2018

1 reference

Topological aspects of oligomeric UDP-glucuronosyltransferases in endoplasmic reticulum membranes: advances and open questions

21 January 2018

1 reference

A historical overview of the heterologous expression of mammalian UDP-glucuronosyltransferase isoforms over the past twenty years.

21 January 2018

1 reference

Role of active metabolites in the use of opioids

21 January 2018

1 reference

Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions

21 January 2018

1 reference

UGT1A1 genotyping: a predictor of irinotecan-associated side effects and drug efficacy?

21 January 2018

1 reference

Testosterone and doping control

21 January 2018

1 reference

Synthesis, structure characterization, and enzyme screening of clenbuterol glucuronides.

21 January 2018

1 reference

Mass spectrometry of steroid glucuronide conjugates. II-Electron impact fragmentation of 3-keto-4-en- and 3-keto-5alpha-steroid-17-O-beta glucuronides and 5alpha-steroid-3alpha,17beta-diol 3- and 17-glucuronides

21 January 2018

1 reference

NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of Ibuprofen ((+/-)-(R,S)-2-(4-isobutylphenyl) propanoic acid), its metabolites, and analogues

21 January 2018

1 reference

Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac

21 January 2018

1 reference

Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.

21 January 2018

1 reference

High-performance liquid chromatography method for determination of N-glucuronidation of 4-aminobiphenyl by mouse, rat, and human liver microsomes

21 January 2018

1 reference

Synthesis and characterization of quaternary ammonium-linked glucuronide metabolites of drugs with an aliphatic tertiary amine group

21 January 2018

1 reference

Predicting circulating human metabolites: how good are we?

21 January 2018

1 reference

Glucuronide production by whole-cell biotransformation using genetically engineered fission yeast Schizosaccharomyces pombe

21 January 2018

1 reference

Human placental glucuronidation and transport of 3'azido-3'-deoxythymidine and uridine diphosphate glucuronic acid

21 January 2018

1 reference

Optimization of the enzymatic hydrolysis and analysis of plasma conjugated gamma-CEHC and sulfated long-chain carboxychromanols, metabolites of vitamin E

21 January 2018

1 reference

Disposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNA.

21 January 2018

1 reference

Isolation and identification of urinary metabolites of kakkalide in rats

21 January 2018

1 reference

Enzymatic production of bile Acid glucuronides used as analytical standards for liquid chromatography-mass spectrometry analyses

21 January 2018

1 reference

The role of human UDP-glucuronyltransferases on the formation of the methylenedioxymethamphetamine (ecstasy) phase II metabolites R- and S-3-methoxymethamphetamine 4-O-glucuronides.

21 January 2018

1 reference

Establishment of Salmonella strain expressing catalytically active human UDP-glucuronosyltransferase 1A1 (UGT1A1).

21 January 2018

1 reference

Glucuronidation of PhIP and N-OH-PhIP by UDP-glucuronosyltransferase 1A10.

21 January 2018

1 reference

The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism

21 January 2018

1 reference

1,3-beta-Glucan synthase: a useful target for antifungal drugs

21 January 2018

1 reference

Characterization of a Schizosaccharomyces pombe mutant deficient in UDP-galactose transport activity

21 January 2018

1 reference

A new approach on the purification of recombinant human soluble catechol-O-methyltransferase from an Escherichia coli extract using hydrophobic interaction chromatography

21 January 2018

1 reference

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.

21 January 2018

1 reference

Comparison of 2-aminophenol and 4-nitrophenol as in vitro probe substrates for the major human hepatic sulfotransferase, SULT1A1, demonstrates improved selectivity with 2-aminophenol.

21 January 2018

1 reference

Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future

21 January 2018

1 reference

Identification and phenotype characterization of two CYP3A haplotypes causing different enzymatic capacity in fetal livers

21 January 2018

1 reference

Discovery of new potentially defective alleles of human CYP2C9.

21 January 2018

1 reference

Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6

21 January 2018

1 reference

Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450

21 January 2018

1 reference

Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.

21 January 2018

1 reference

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene

21 January 2018

1 reference

Improved cloning and expression of cytochrome P450s and cytochrome P450 reductase in yeast

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/BIO.10.80

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21083240%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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