(Q28298981)

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

The animal pharmacology of buprenorphine, an oripavine analgesic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

Pharmacokinetics of dextropropoxyphene and nordextropropoxyphene in young and elderly volunteers after single and multiple dextropropoxyphene dosage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

Morphine-6-O-beta-D-glucuronide but not morphine-3-O-beta-D-glucuronide binds to mu-, delta- and kappa- specific opioid binding sites in cerebral membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

The pharmacokinetics of morphine and morphine glucuronides in kidney failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

The analgesic activity of morphine-6-glucuronide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

The pharmacokinetics of oxycodone after intravenous injection in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0570-Y

Morphine-6-glucuronide: analgesic effects and receptor binding profile in rats.

21 January 2018

1 reference

12 December 2020

A randomized, double-blind, placebo-controlled pilot study of IV morphine-6-glucuronide for postoperative pain relief after knee replacement surgery

1 reference

12 December 2020

The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties

1 reference

12 December 2020

The effects of tramadol on static and dynamic pupillometry in healthy subjects--the relationship between pharmacodynamics, pharmacokinetics and CYP2D6 metaboliser status

1 reference

12 December 2020

Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception

1 reference

12 December 2020

Morphine-3-glucuronide may functionally antagonize morphine-6-glucuronide induced antinociception and ventilatory depression in the rat

1 reference

12 December 2020

Morphine-6-glucuronide: effects on ventilation in normal volunteers

1 reference

12 December 2020

Opiate receptor binding of nicomorphine and its hydrolysis products in rat brain.

1 reference

12 December 2020

Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents

1 reference

12 December 2020

Morphine-6-Glucuronide: Receptor Binding Profile in Bovine Caudate Nucleus

1 reference

12 December 2020

Affinities of some common opioid analgesics towards four binding sites in mouse brain

1 reference

12 December 2020

Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans

1 reference

12 December 2020

CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes.

1 reference

12 December 2020

Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6 alpha- and 6 beta-naltrexol

1 reference

12 December 2020

Loss of analgesic effect of morphine due to coadministration of rifampin

1 reference

12 December 2020

Morphine-3-glucuronide has a minor effect on morphine antinociception. Pharmacodynamic modeling.

1 reference

12 December 2020

Polymorphic O-demethylation of codeine

1 reference

12 December 2020

Morphine-6-glucuronide is more mu-selective and potent in analgesic tests than morphine.

1 reference

12 December 2020

Buprenorphine induces ceiling in respiratory depression but not in analgesia

1 reference

12 December 2020

Pharmacokinetics of tilidine and metabolites in man

1 reference

12 December 2020

Potentiation of physical dependence by conjugation at the 6-position of nalorphine.

1 reference

12 December 2020

Analgesic Effect of Morphine Glucuronides

1 reference

12 December 2020

Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor

1 reference

12 December 2020

Pharmacokinetics of methadone and its primary metabolite in 20 opiate addicts.

1 reference

12 December 2020

Lack of morphine-6-glucuronide antinociception after morphine treatment. Is morphine-3-glucuronide involved?

1 reference

12 December 2020

3Hsufentanil, a superior ligand for μ-opiate receptors: Binding properties and regional distribution in rat brain and spinal cord

1 reference

12 December 2020

Morphine-6-glucuronide has high affinity for the opioid receptor

1 reference

12 December 2020

The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated

1 reference

12 December 2020

Unwanted effects of morphine-6-glucoronide and morphine

1 reference

12 December 2020

Limited phase I study of morphine-3-glucuronide

1 reference

12 December 2020

Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes

1 reference

12 December 2020

Neuroexcitatory effects of morphine and hydromorphone: evidence implicating the 3-glucuronide metabolites

1 reference

12 December 2020

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

1 reference

12 December 2020

Analgesic action of pethidine derivatives and related compounds

1 reference

12 December 2020

Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers

1 reference

12 December 2020

Metabolism and pharmacokinetics of naloxone

1 reference

12 December 2020

Heroin acts on different opioid receptors than morphine in Swiss Webster and ICR mice to produce antinociception

1 reference

12 December 2020

Buprenorphine has potent kappa opioid receptor antagonist activity

1 reference

12 December 2020

Pharmacokinetics of high doses of intramuscular and oral heroin in narcotic addicts

1 reference

12 December 2020

Supraspinal delta receptor subtype activity of heroin and 6-monoacetylmorphine in Swiss Webster mice

1 reference

12 December 2020

The pharmacokinetics of butorphanol and its metabolites at steady state following nasal administration in humans

1 reference

12 December 2020

Affinities of dihydrocodeine and its metabolites to opioid receptors

1 reference

12 December 2020

The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model.

1 reference

12 December 2020

Comparisons of the Analgesic Effects of Oral and Intramuscular Oxymorphone and of Intramuscular Oxymorphone and Morphine in Patients with Cancer

1 reference

12 December 2020

Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer.

1 reference

12 December 2020

Analgesic and immunomodulatory effects of codeine and codeine 6-glucuronide

1 reference

12 December 2020

Codeine intoxication associated with ultrarapid CYP2D6 metabolism

1 reference

12 December 2020

Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist

1 reference

12 December 2020

Morphine-6beta-glucuronide and morphine-3-glucuronide, opioid receptor agonists with different potencies

1 reference

12 December 2020

The pharmacokinetics of ketobemidone are not affected by CYP2D6 or CYP2C19 phenotype

1 reference

12 December 2020

The effect of N-demethylation on certain pharmacologic actions of morphine, codeine, and meperidine in the mouse

1 reference

12 December 2020

Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain

1 reference

12 December 2020

Human UGT2B7 catalyzes morphine glucuronidation

1 reference

12 December 2020

Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis

1 reference

12 December 2020

The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268).

1 reference

12 December 2020

In vivo and in vitro potency studies of 6beta-naltrexol, the major human metabolite of naltrexone

1 reference

12 December 2020

Evaluation of levo-alpha-acetylmethdol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: a pharmacokinetic and pharmacodynamic analysis

1 reference

12 December 2020

Meperidine: a critical review

1 reference

12 December 2020

Pharmacokinetics of tilidine and naloxone in patients with severe hepatic impairment

1 reference

12 December 2020

Pharmacokinetics of tilidine in terminal renal failure

1 reference

12 December 2020

Capillary electrophoresis contributions to the hydromorphone metabolism in man.

1 reference

12 December 2020

Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats

1 reference

12 December 2020

Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes

1 reference

12 December 2020

Preemptive intravenous morphine-6-glucuronide is ineffective for postoperative pain relief

1 reference

12 December 2020

Pharmacogenetic determination of the effects of codeine and prediction of drug interactions

1 reference

12 December 2020

Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity

1 reference

12 December 2020

In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice

1 reference

12 December 2020

Dextropropoxyphene acts as a noncompetitive N-methyl-D-aspartate antagonist

1 reference

12 December 2020

Effect of naloxone-3-glucuronide and N-methylnaloxone on the motility of the isolated rat colon after morphine

1 reference

12 December 2020

Peripheral opioid analgesia in experimental human pain models

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data

1 reference

12 December 2020

Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine

1 reference

12 December 2020

Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites

1 reference

12 December 2020

Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites

1 reference

12 December 2020

Plasma morphine and glucuronide (M3G and M6G) concentrations in hospice inpatients

1 reference

12 December 2020

The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats

1 reference

12 December 2020

Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence.

1 reference

12 December 2020

Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil.

1 reference

12 December 2020

1 reference

12 December 2020

Old dog--new (ma)trix

1 reference

12 December 2020

Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients undergoing tooth extraction.

1 reference

12 December 2020

Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine

1 reference

12 December 2020

Pharmacokinetics of intravenously administered nicomorphine and its metabolites in man

1 reference

12 December 2020

CYP2D6 polymorphism, tramadol pharmacokinetics and pupillary response.

1 reference

12 December 2020

Tramadol as a new probe for cytochrome P450 2D6 phenotyping: a population study

1 reference

12 December 2020

Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes

1 reference

12 December 2020

Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

1 reference

12 December 2020

Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action.

1 reference

12 December 2020

Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide.

1 reference

12 December 2020

Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers

1 reference

12 December 2020

Randomized placebo-controlled trial of the activity of the morphine glucuronides

1 reference

12 December 2020

Mu receptor binding of some commonly used opioids and their metabolites

1 reference

12 December 2020

Analgesic effect and plasma concentrations of codeine and morphine after two dose levels of codeine following oral surgery

1 reference

12 December 2020

Comparative pharmacokinetics and pharmacodynamics of remifentanil, its principle metabolite (GR90291) and alfentanil in dogs

1 reference

12 December 2020

Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication.

1 reference

12 December 2020

Pharmacodynamic Effect of Morphine-6-glucuronide versus Morphine on Hypoxic and Hypercapnic Breathing in Healthy Volunteers

1 reference

12 December 2020

Hydrolysis of diacetylmorphine (heroin) by human serum cholinesterase

1 reference

12 December 2020

Clinical significance of esterases in man.

1 reference

12 December 2020

Pharmacological effects of nalorphine and nalorphine-7,8-oxide (nalorphine-epoxide): interaction of the intrinsic activity, affinity and pharmacological responses.

1 reference

12 December 2020

The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross-over study with extensive and quinidine-induced poor metabolizers

1 reference

12 December 2020

Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position

1 reference

12 December 2020

Opioid receptor activity of GI 87084B, a novel ultra-short acting analgesic, in isolated tissues

1 reference

12 December 2020

Remifentanil : a review of its analgesic and sedative use in the intensive care unit

1 reference

12 December 2020

Activation of G-Proteins by Morphine and Codeine Congeners: Insights to the Relevance of O- and N-Demethylated Metabolites at μ- and δ-Opioid Receptors

1 reference

12 December 2020

The hypoalgesic effect of tramadol in relation to CYP2D6*

1 reference

12 December 2020

A comparison of intrathecal morphine-6-glucuronide and intrathecal morphine sulfate as analgesics for total hip replacement

1 reference

12 December 2020

Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog

1 reference

12 December 2020

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide-induced analgesia in healthy volunteers: absence of sex differences

1 reference

12 December 2020

Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem time-of-flight mass spectrometry.

1 reference

12 December 2020

Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers*

1 reference

12 December 2020

Sequential first-pass metabolism of nortilidine: the active metabolite of the synthetic opioid drug tilidine

1 reference

12 December 2020

Morphine-6-glucuronide, a potent mu agonist.

1 reference

12 December 2020

Drug therapy reviews: evaluation of butorphanol tartrate

1 reference

12 December 2020

Hydromorphone metabolites: isolation and identification from pooled urine samples of a cancer patient

1 reference

12 December 2020

The heroin metabolite, 6-monoacetylmorphine, activates delta opioid receptors to produce antinociception in Swiss-Webster mice

1 reference

12 December 2020

Arterial and venous pharmacokinetics of intravenous heroin in subjects who are addicted to narcotics

1 reference

12 December 2020

Identification of Diacetylmorphine Metabolites in Humans

1 reference

12 December 2020

Pharmacokinetics and neurochemical effects of pentazocine and its optical isomers

1 reference

12 December 2020

Purification and characterization of two major forms of naloxone reductase from rabbit liver cytosol, new members of aldo-keto reductase superfamily

1 reference

12 December 2020

Levorphanol: pharmacokinetics and steady-state plasma concentrations in patients with pain

1 reference

12 December 2020

Actions of tilidine and nortilidine on cloned opioid receptors

1 reference

12 December 2020

Respiratory depression following morphine and morphine-6-glucuronide in normal subjects.

1 reference

12 December 2020

Analgesic studies of codeine and oxycodone in patients with cancer. II. Comparisons of intramuscular oxycodone with intramuscular morphine and codeine

1 reference

12 December 2020

The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6.

1 reference

12 December 2020

Serum time course of naltrexone and 6β-naltrexol levels during long term treatment in drug addicts

1 reference

12 December 2020

Oxymorphone: a review

1 reference

12 December 2020

Disposition of parenteral butorphanol in man

1 reference

12 December 2020

Effect of prior morphine-3-glucuronide exposure on morphine disposition and antinociception

1 reference

12 December 2020

Miotic action of tramadol is determined by CYP2D6 genotype

1 reference

12 December 2020

Pharmacogenetics of opioids

1 reference

12 December 2020

Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities.

1 reference

12 December 2020

Human brain metabolism of morphine and naloxone

1 reference

12 December 2020

A rapid and simple CYP2D6 genotyping assay--case study with the analgetic tramadol

1 reference

12 December 2020

Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents

1 reference

12 December 2020

Hydromorphone-3-glucuronide: a more potent neuro-excitant than its structural analogue, morphine-3-glucuronide.

1 reference

12 December 2020

Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein

1 reference

12 December 2020

Pharmacokinetics and metabolism of codeine in humans

1 reference

12 December 2020

Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?

1 reference

12 December 2020

Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

1 reference

12 December 2020

Post-mortem SNP analysis of CYP2D6 gene reveals correlation between genotype and opioid drug (tramadol) metabolite ratios in blood

1 reference

12 December 2020

d-morphine, but not l-morphine, has low micromolar affinity for the non-competitive N-methyl-D-aspartate site in rat forebrain. Possible clinical implications for the management of neuropathic pain.

1 reference

12 December 2020

CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes

1 reference

12 December 2020

Analgesic efficacy and CSF pharmacokinetics of intrathecal morphine-6-glucuronide: comparison with morphine

1 reference

12 December 2020

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

1 reference

12 December 2020

Single-dose and steady-state kinetics of morphine and its metabolites in cancer patients--a comparison of two oral formulations

1 reference

12 December 2020

Isolation and identification of urinary metabolites of oxycodone in rabbits

1 reference

12 December 2020

Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes

1 reference

12 December 2020

The pharmacogenetics of codeine hypoalgesia.

1 reference

12 December 2020

Comparison of cerebral pharmacokinetics of buprenorphine and norbuprenorphine in an in vivo sheep model.

1 reference

12 December 2020

CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement

1 reference

12 December 2020

mu Opioid receptor-mediated G-protein activation by heroin metabolites: evidence for greater efficacy of 6-monoacetylmorphine compared with morphine

1 reference

12 December 2020

Codeine in post-operative pain

1 reference

12 December 2020

Complicated pain management in a CYP450 2D6 poor metabolizer

1 reference

12 December 2020

The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex.

1 reference

12 December 2020