(Q36752672)

16 August 2017

1 reference

title

Pharmacogenetics of opioids (English)

1 reference

16 August 2017

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2

Daniel T Barratt

1 reference

16 August 2017

Andrew A Somogyi

1

1 reference

16 August 2017

Janet K Coller

series ordinal

3

1 reference

16 August 2017

language of work or name

English

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publication date

1 March 2007

1 reference

Clinical Pharmacology & Therapeutics

16 August 2017

published in

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16 August 2017

volume

81

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16 August 2017

issue

3

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16 August 2017

page(s)

429-444

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Relationships between measurement of pain using visual analog score and morphine requirements during postoperative intravenous morphine titration

16 August 2017

cites work

1 reference

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Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample size

21 January 2018

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GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

21 January 2018

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Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament

21 January 2018

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Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans

21 January 2018

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COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor

21 January 2018

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How individual sensitivity to opiates can be predicted by gene analyses

21 January 2018

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Are mu-opioid receptor polymorphisms important for clinical opioid therapy?

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

21 January 2018

1 reference

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A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling

21 January 2018

1 reference

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Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor

21 January 2018

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Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide-induced analgesia in healthy volunteers: absence of sex differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Polymorphism of mu-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Clinical response to morphine in cancer patients and genetic variation in candidate genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Intra- and inter-ethnic differences in the allele frequencies of cytochrome P450 2B6 gene in Chinese.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Opioids bind to the amino acids 84 to 118 of UDP-glucuronosyltransferase UGT2B7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Plasma codeine and morphine concentrations after therapeutic oral doses of codeine-containing analgesics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Comparative disposition of codeine and pholcodine in man after single oral doses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

A rapid and simple CYP2D6 genotyping assay--case study with the analgetic tramadol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Post-mortem SNP analysis of CYP2D6 gene reveals correlation between genotype and opioid drug (tramadol) metabolite ratios in blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective O-demethylation and reduces the hypoalgesic effect of tramadol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of methadone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Impact of environmental and genetic factors on codeine analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Affinities of dihydrocodeine and its metabolites to opioid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Patient-controlled analgesia (PCA) with codeine for postoperative pain relief in ten extensive metabolisers and one poor metaboliser of dextromethorphan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Attenuation of morphine-induced delirium in palliative care by substitution with infusion of oxycodone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Impact of CYP2D6 genotype on postoperative tramadol analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Predicting response to lithium in mood disorders: role of genetic polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype*

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Codeine intoxication associated with ultrarapid CYP2D6 metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

ABC of oral bioavailability: transporters as gatekeepers in the gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Expression and function of efflux drug transporters in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Importance of P-glycoprotein at blood-tissue barriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Clinical relevance of P-glycoprotein in drug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Role of P-glycoprotein in pharmacokinetics: clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Effect of P-glycoprotein inhibition on methadone analgesia and brain distribution in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Variable modulation of opioid brain uptake by P-glycoprotein in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Increased drug delivery to the brain by P-glycoprotein inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Effect of P-glycoprotein modulation on the clinical pharmacokinetics and adverse effects of morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Transport systems for opioid peptides in mammalian tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Enhanced antinociception of the model opioid peptide [D-penicillamine] enkephalin by P-glycoprotein modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

MDR1 P-glycoprotein transports endogenous opioid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Implications of genetic polymorphisms in drug transporters for pharmacotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

MDR1 polymorphisms G2677T in exon 21 and C3435T in exon 26 fail to affect rhodamine 123 efflux in peripheral blood lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Identification of functionally variant MDR1 alleles among European Americans and African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Frequency of C3435T polymorphism of MDR1 gene in African people

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

The effect of food components on the absorption of P-gp substrates: a review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Carrier-mediated processes at several rat brain interfaces determine the neuropharmacokinetics of morphine and morphine-6-beta-D-glucuronide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Mammalian ABC transporters in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Tissue distribution and induction of human multidrug resistant protein 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Endomorphins, Met-enkephalin, Tyr-MIF-1, and the P-glycoprotein efflux system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Cytochrome P450 2D6 Genotype and Methadone Steady-State Concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

Plasma morphine and glucuronide (M3G and M6G) concentrations in hospice inpatients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Individualizing analgesic prescription Part I: pharmacogenetics of opioid analgesics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Genetic basis for individual variations in pain perception and the development of a chronic pain condition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Pharmacogenetics of opioid receptors and addiction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Environmental and genetic factors associated with morphine response in the postoperative period

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Influence of CYP2D6 Genetics on Opioid Kinetics, Metabolism and Response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Haplotype analysis of UDP-glucuronocyltransferase 2B7 gene (UGT2B7) polymorphisms in healthy Japanese subjects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: relationship to the presence of immunoidentified cytochrome P-450IID1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Glucuronidation of dihydrocodeine by human liver microsomes and the effect of inhibitors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Codeine disposition in smokers and nonsmokers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Plasma concentrations of codeine and its metabolite, morphine, after single and repeated oral administration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Plasma codeine and morphine concentrations after a single oral dose of codeine phosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Polymorphic O-demethylation of codeine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Quantification of the O- and N-demethylated and the glucuronidated metabolites of codeine relative to the debrisoquine metabolic ratio in urine in ultrarapid, rapid, and poor debrisoquine hydroxylators

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Urinary excretion of codeine, ethylmorphine, and their metabolites: relation to the CYP2D6 activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

The hypoalgesic effect of tramadol in relation to CYP2D6*

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

CYP2D6 polymorphism, tramadol pharmacokinetics and pupillary response.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Tramadol as a new probe for cytochrome P450 2D6 phenotyping: a population study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Paroxetine increases steady-state concentrations of (R)-methadone in CYP2D6 extensive but not poor metabolizers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

The effect of quinidine on the analgesic effect of codeine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Codeine in post-operative pain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

The effect of codeine on gastrointestinal transit in extensive and poor metabolisers of debrisoquine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Transporters as a determinant of drug clearance and tissue distribution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

G2677T and C3435T Genotype and Haplotype Are Associated With HepaticABCB1(MDR1) Expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Quantitative determination of MDR1 mRNA expression in peripheral blood lymphocytes: a possible role of genetic polymorphisms in the MDR1 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Using saccadic eye movements as objective measures of tolerance in methadone dependent individuals during the hydromorphone challenge test

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

MDR1 single nucleotide polymorphisms: multiplicity of haplotypes and functional consequences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Increased brain P-glycoprotein in morphine tolerant rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Linkage disequilibrium and haplotype architecture for two ABC transporter genes (ABCC1 and ABCG2) in Chinese population: implications for pharmacogenomic association studies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

Current evidence for a genetic modulation of the response to analgesics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100095

7 January 2021

An empirical evaluation of multifarious outcomes in pharmacogenetics: beta-2 adrenoceptor gene polymorphisms in asthma treatment

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.CLPT.6100095

1 reference

16 August 2017

1 reference