(Q37825904)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

review article

1 reference

title

Targeting liver X receptors in human health: deadlock or promising trail? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1

1 reference

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19 January 2020

Abdelkader Oumeddour

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Aurélien J C Pommier

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Kévin Mouzat

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Fatim-Zohra El Hajjaji

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Julie Dufour

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Françoise Caira

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

David H Volle

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Silvère Baron

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Jean-Marc A Lobaccaro

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

language of work or name

English

0 references

publication date

5 January 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

19 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

219-232

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204733%20AND%20SRC:MED&resulttype=core&format=json

The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

19 January 2020

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21 January 2018

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An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

21 January 2018

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Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

21 January 2018

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Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

21 January 2018

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SIRT1 deacetylates and positively regulates the nuclear receptor LXR

21 January 2018

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Liver X receptors interact with corepressors to regulate gene expression

21 January 2018

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Nuclear receptor corepressors

21 January 2018

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Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors

21 January 2018

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Crystal structure of the heterodimeric complex of LXR and RXR ligand-binding domains in a fully agonistic conformation

21 January 2018

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Are side-chain oxidized oxysterols regulators also in vivo?

21 January 2018

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Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.

21 January 2018

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Selective activation of liver X receptor alpha by 6alpha-hydroxy bile acids and analogs

21 January 2018

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Steroidal and triterpenoidal fungal metabolites as ligands of liver X receptors

21 January 2018

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Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources

21 January 2018

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A novel LXR-alpha activator identified from the natural product Gynostemma pentaphyllum

21 January 2018

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Liver X receptor modulators: a review of recently patented compounds (2007 - 2009).

21 January 2018

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Role of LXRs in control of lipogenesis

21 January 2018

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Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines

21 January 2018

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T0901317 is a dual LXR/FXR agonist

21 January 2018

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CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor

21 January 2018

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Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

21 January 2018

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Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype

21 January 2018

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Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

21 January 2018

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Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist

21 January 2018

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Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo

21 January 2018

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Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants.

21 January 2018

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Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells

21 January 2018

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Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist

21 January 2018

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Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

21 January 2018

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Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.

21 January 2018

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Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c

21 January 2018

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Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand

21 January 2018

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Riccardin C: a natural product that functions as a liver X receptor (LXR)alpha agonist and an LXRbeta antagonist

21 January 2018

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Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

21 January 2018

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A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.

21 January 2018

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Orphan nuclear receptors: shifting endocrinology into reverse

21 January 2018

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Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

21 January 2018

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Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).

21 January 2018

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Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

21 January 2018

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Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia

21 January 2018

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Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein

21 January 2018

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LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

21 January 2018

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

21 January 2018

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The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

21 January 2018

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Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

21 January 2018

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Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells.

21 January 2018

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Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling

21 January 2018

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LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

21 January 2018

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Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels

21 January 2018

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Liver X receptors regulate adrenal cholesterol balance

21 January 2018

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Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility

21 January 2018

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The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis.

21 January 2018

1 reference

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Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.

21 January 2018

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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

21 January 2018

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Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages

21 January 2018

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Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism

21 January 2018

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The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages

21 January 2018

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Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways

21 January 2018

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Synthetic LXR ligand inhibits the development of atherosclerosis in mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis

21 January 2018

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LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse

21 January 2018

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Functional genomics of blood cellular LXR-alpha gene in human coronary heart disease

21 January 2018

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Obesity and the metabolic syndrome in developing countries

21 January 2018

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Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

21 January 2018

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Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathway

21 January 2018

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Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity

21 January 2018

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Brain cholesterol in normal and pathological aging

21 January 2018

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Statins and the risk of dementia

21 January 2018

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Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.547853

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.547853

The selective Alzheimer's disease indicator-1 gene (Seladin-1/DHCR24) is a liver X receptor target gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Gene-gene interaction between heme oxygenase-1 and liver X receptor-beta and Alzheimer's disease risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Regulation of ABCA1 expression in human keratinocytes and murine epidermis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Reduced fertility and inability of oocytes to resume meiosis in mice deficient of the Lxr genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Liver X receptors and epididymal epithelium physiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853

LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner

21 January 2018

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Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells

21 January 2018

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The oxysterol receptor LXR inhibits proliferation of human breast cancer cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Liver X receptor ligands suppress ubiquitination and degradation of LXRalpha by displacing BARD1/BRCA1.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.547853

Studies on Prostatic Cancer: I. The Effect of Castration, Of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate

21 January 2018

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Comparative studies of prostate cancer in Japan versus the United States. A review

21 January 2018

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Hypercholesterolemia and prostate cancer: a hospital-based case-control study

21 January 2018

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Statin drugs and risk of advanced prostate cancer

21 January 2018

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Statins and prostate cancer risk: a case-control study

21 January 2018

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Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells

21 January 2018

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Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.

21 January 2018

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Androgenic suppression of ATP-binding cassette transporter A1 expression in LNCaP human prostate cancer cells

21 January 2018

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Stromal growth and epithelial cell proliferation in ventral prostates of liver X receptor knockout mice

21 January 2018

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The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands

21 January 2018

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[Nuclear liver X receptors are involved in the biology of reproduction].

21 January 2018

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Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.547853