(Q37840104)

24 August 2017

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title

Novel IkB kinase inhibitors for treatment of nuclear factor-kB-related diseases (English)

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24 August 2017

Jun-ichi Suzuki

1

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24 August 2017

Masahito Ogawa

2

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24 August 2017

Susumu Muto

3

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24 August 2017

Akiko Itai

4

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24 August 2017

Mitsuaki Isobe

5

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24 August 2017

Yasunobu Hirata

6

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24 August 2017

Ryozo Nagai

7

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24 August 2017

language of work or name

English

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publication date

1 March 2011

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Expert Opinion on Investigational Drugs

24 August 2017

published in

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24 August 2017

volume

20

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24 August 2017

issue

3

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24 August 2017

page(s)

395-405

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New regulators of NF-kappaB in inflammation

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

NF-kappaB: linking inflammation and immunity to cancer development and progression

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.559162

IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.559162

The NF-kappaB family of transcription factors and its regulation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Missing pieces in the NF-kappaB puzzle

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.559162

NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Inhibition of NF-{kappa}B improves left ventricular remodeling and cardiac dysfunction after myocardial infarction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Novel IKK inhibitors: beta-carbolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-alpha in Jurkat leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kappaB essential modulator binding domain peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

A highly selective inhibitor of IkappaB kinase, BMS-345541, augments graft survival mediated by suboptimal immunosuppression in a murine model of cardiac graft rejection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Selective inhibition of inhibitory kappa B kinase-beta abrogates induction of nitric oxide synthase in lipopolysaccharide-stimulated rat aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Tea catechins attenuate ventricular remodeling and graft arterial diseases in murine cardiac allografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Dietary consumption of green tea catechins attenuate hyperlipidaemia-induced atherosclerosis and systemic organ damage in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Nuclear factor-kappaB decoy oligodeoxynucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Selective blockade of NF-kappa B activity in airway immune cells inhibits the effector phase of experimental asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Antiallergic and anti-inflammatory effects of a novel I kappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Inhibition of tumor necrosis factor-alpha-inducible inflammatory genes by interferon-gamma is associated with altered nuclear factor-kappaB transactivation and enhanced histone deacetylase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

IL-13 induces translocation of NF-kappaB in cultured human bronchial smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Prevention and regression of atopic dermatitis by ointment containing NF-kB decoy oligodeoxynucleotides in NC/Nga atopic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

A new IkappaB kinase beta inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Selective Inhibition of I B Kinase Sensitizes Mantle Cell Lymphoma B Cells to TRAIL by Decreasing Cellular FLIP Level

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Sensitization of neuroblastoma cells for TRAIL-induced apoptosis by NF-kappaB inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

NF-kappa B as a therapeutic target in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Selective efficacy of depsipeptide in a xenograft model of Epstein-Barr virus-positive lymphoproliferative disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Prostate stem cell antigen is overexpressed in prostate cancer metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Interleukin 6, a nuclear factor-kappaB target, predicts resistance to docetaxel in hormone-independent prostate cancer and nuclear factor-kappaB inhibition by PS-1145 enhances docetaxel antitumor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Nuclear factor-kappaB activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

NF-kappaB inhibition triggers death of imatinib-sensitive and imatinib-resistant chronic myeloid leukemia cells including T315I Bcr-Abl mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Active roles for inhibitory kappaB kinases alpha and beta in nuclear factor-kappaB-mediated chemoresistance to doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Nuclear factor kappa B decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Antineuroinflammatory effect of NF-kappaB essential modifier-binding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Inherited disorders of NF-kappaB-mediated immunity in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Validation of the Anti-Inflammatory Properties of Small-Molecule I B Kinase (IKK)-2 Inhibitors by Comparison with Adenoviral-Mediated Delivery of Dominant-Negative IKK1 and IKK2 in Human Airways Smooth Muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

Repression of Inflammatory Gene Expression in Human Pulmonary Epithelial Cells by Small-Molecule I B Kinase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.559162

10.1517/13543784.2011.559162

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference