(Q37844444)

24 August 2017

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title

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity (English)

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24 August 2017

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Paul M van Midwoud

1

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24 August 2017

Elisabeth Verpoorte

series ordinal

2

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24 August 2017

Geny M M Groothuis

series ordinal

3

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24 August 2017

publication date

17 February 2011

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24 August 2017

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24 August 2017

volume

3

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24 August 2017

issue

5

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24 August 2017

page(s)

509-521

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Can the pharmaceutical industry reduce attrition rates?

24 August 2017

cites work

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Key factors in the rising cost of new drug discovery and development

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An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

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Strategies for using in vitro screens in drug metabolism

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Toxicity testing: the search for an in vitro alternative to animal testing

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Pharmacokinetics in drug discovery

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A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction

21 January 2018

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Membrane-based PDMS microbioreactor for perfused 3D primary rat hepatocyte cultures.

21 January 2018

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A practical guide to microfluidic perfusion culture of adherent mammalian cells.

21 January 2018

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Cell culture models in microfluidic systems

21 January 2018

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Lab-on-a-chip: microfluidics in drug discovery

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0IB00119H

In vitro microscale systems for systematic drug toxicity study

21 January 2018

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Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity

21 January 2018

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Liver tissue engineering in the evaluation of drug safety

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0IB00119H

Microengineering of cellular interactions

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0IB00119H

Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0IB00119H

Generation of complex concentration profiles by partial diffusive mixing in multi-stream laminar flow.

21 January 2018

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A microfluidic gradient maker for toxicity testing of bupivacaine and lidocaine

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0IB00119H

Cell-based high content screening using an integrated microfluidic device

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0IB00119H

Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with special reference to non-hepatic tissues

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0IB00119H

In vitro mimicry of metabolic oxidation reactions by electrochemistry/mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

A microfluidic chip for electrochemical conversions in drug metabolism studies.

21 January 2018

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Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0IB00119H

Chip-based P450 drug metabolism coupled to electrospray ionization-mass spectrometry detection

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0IB00119H

Microreactor microfluidic systems with human microsomes and hepatocytes for use in metabolite studies.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0IB00119H

On-line drug-metabolism system using microsomes encapsulated in a capillary by the sol-gel method and integrated into capillary electrophoresis

21 January 2018

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Hayflick, his limit, and cellular ageing.

21 January 2018

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Identity tests: determination of cell line cross-contamination

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Identification of HepG2 variant cell lines by short tandem repeat (STR) analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Development of a microscale cell culture analog to probe naphthalene toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

In vitro analysis of a hepatic device with intrinsic microvascular-based channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Microfluidic environment for high density hepatocyte culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0IB00119H

A microfluidic platform for 3-dimensional cell culture and cell-based assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Materials science. Hydrogel cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

PDMS absorption of small molecules and consequences in microfluidic applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Progress in human hepatocytes: isolation, culture & cryopreservation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes, cultured in the absence or presence of dexamethasone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture

21 January 2018

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https://api.crossref.org/works/10.1039%2FC0IB00119H

The controlled presentation of TGF-beta1 to hepatocytes in a 3D-microfluidic cell culture system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Perfused multiwell plate for 3D liver tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

A microfluidic 3D hepatocyte chip for drug toxicity testing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

A novel 3D mammalian cell perfusion-culture system in microfluidic channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

TGF-beta1 gene silencing for treating liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

TGFbeta1 in liver fibrosis: time to change paradigms?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Capturing complex 3D tissue physiology in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Evaluation of diffusion in gel entrapment cell culture within hollow fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Interaction between hepatocytes and collagen gel in hollow fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Long-term maintenance of hepatocyte functional activity in co-culture: requirements for sinusoidal endothelial cells and dexamethasone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Stimulation of growth of primary cultured adult rat hepatocytes without growth factors by coculture with nonparenchymal liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Layered patterning of hepatocytes in co-culture systems using microfabricated stencils

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Microscale culture of human liver cells for drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Perfusion culture of fetal human hepatocytes in microfluidic environments

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Perfusion cell seeding and cultivation induce the assembly of thick and functional hepatocellular tissue-like construct

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Cryopreservation of isolated human hepatocytes for transplantation: State of the art.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Use of precision-cut rat liver slices for studies of xenobiotic metabolism and toxicity: comparison of the Krumdieck and Brendel tissue slicers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Patch-clamp studies in the CNS illustrate a simple new method for obtaining viable neurons in rat brain slices: glycerol replacement of NaCl protects CNS neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Induction of cytochrome P450 2B6 and 3A4 expression by phenobarbital and cyclophosphamide in cultured human liver slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Precision-cut tissue slices as a tool to predict metabolism of novel drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Effect of oxygen pressure on glycogen synthesis by rat-liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Muscular tissue engineering: capillary-incorporated hybrid muscular tissues in vivo tissue culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Assessment of regional cytochrome P450 activities in rat liver slices using resorufin substrates and fluorescence confocal laser cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Novel intra-tissue perfusion system for culturing thick liver tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

On-line HPLC analysis system for metabolism and inhibition studies in precision-cut liver slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Coincubation of tissue slices, a new way to study metabolic cooperation between organs: hepatorenal cooperation in the biotransformation of CGP 47 969 A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Bile acids: regulation of synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Characterization of ANIT-induced toxicity using precision-cut rat and dog liver slices cultured in a dynamic organ roller system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Integration and detection of biochemical assays in digital microfluidic LOC devices

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

Microchip-based high-throughput screening analysis of combinatorial libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

21 January 2018

A review of micropumps

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

An update on metabolism studies using human hepatocytes in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0IB00119H

21 January 2018

Identifiers

DOI

10.1039/C0IB00119H

1 reference

24 August 2017

1 reference