(Q37851076)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

review article

1 reference

title

MR evaluation of response to targeted treatment in cancer cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Egidio Iorio

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

author name string

Franca Podo

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Silvana Canevari

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Maria Elena Pisanu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Alessandro Ricci

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

publication date

8 March 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

volume

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

page(s)

648-672

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

cites work

The Hallmarks of Cancer

1 reference

Molecular predictors of response and outcome in ovarian cancer.

21 January 2018

1 reference

Gene expression in fixed tissues and outcome in hepatocellular carcinoma.

21 January 2018

1 reference

Molecular classification of solid tumours: towards pathway-driven therapeutics

21 January 2018

1 reference

Metabolic profiles of cancer cells

21 January 2018

1 reference

Clinical applications of metabolomics in oncology: a review

21 January 2018

1 reference

Metabolic oxidation regulates embryonic stem cell differentiation

21 January 2018

1 reference

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

21 January 2018

1 reference

Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors.

21 January 2018

1 reference

Studies of human tumors by MRS: a review

21 January 2018

1 reference

Tumour phospholipid metabolism

21 January 2018

1 reference

Proton MRS can determine the pathology of human cancers with a high level of accuracy.

21 January 2018

1 reference

In vivo magnetic resonance spectroscopy in cancer.

21 January 2018

1 reference

Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions.

21 January 2018

1 reference

Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism

21 January 2018

1 reference

Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer

21 January 2018

1 reference

Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy

21 January 2018

1 reference

Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer

21 January 2018

1 reference

Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR

21 January 2018

1 reference

Glycolysis in cancer: a potential target for therapy.

21 January 2018

1 reference

Glucose metabolism and cancer

21 January 2018

1 reference

Mitochondria and cancer: Warburg addressed

21 January 2018

1 reference

1H NMR visible lipids in the life and death of cells

21 January 2018

1 reference

Many roads lead to the lipid droplet

21 January 2018

1 reference

Triacsin C inhibits the formation of 1H NMR-visible mobile lipids and lipid bodies in HuT 78 apoptotic cells

21 January 2018

1 reference

Phenylbutyrate induces apoptosis and lipid accumulations via a peroxisome proliferator-activated receptor gamma-dependent pathway

21 January 2018

1 reference

In vivo 31P MRS of experimental tumours

21 January 2018

1 reference

Phospholipid biosynthesis in mammalian cells

21 January 2018

1 reference

Expression of human choline kinase in NIH 3T3 fibroblasts increases the mitogenic potential of insulin and insulin-like growth factor I.

21 January 2018

1 reference

Structure and function of choline kinase isoforms in mammalian cells

21 January 2018

1 reference

Choline Kinase: An Important Target for Cancer

21 January 2018

1 reference

Phosphatidylcholine-specific phospholipase C in mitogen-stimulated fibroblasts

21 January 2018

1 reference

Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells

21 January 2018

1 reference

Activation of phosphatidylcholine cycle enzymes in human epithelial ovarian cancer cells

21 January 2018

1 reference

Choline phospholipid metabolism: a target in cancer cells?

21 January 2018

1 reference

Phosphomonoester concentrations differ between chronic lymphocytic leukemia cells and normal human lymphocytes

21 January 2018

1 reference

Loss of p53 function in colon cancer cells results in increased phosphocholine and total choline

21 January 2018

1 reference

Alterations of choline phospholipid metabolism in ovarian tumor progression

21 January 2018

1 reference

Phosphocholine as a biomarker of breast cancer: molecular and biochemical studies

21 January 2018

1 reference

Phosphatidylcholine and choline homeostasis.

21 January 2018

1 reference

The absorption and transport of lipids by the small intestine

21 January 2018

1 reference

Characterization of breast cancers and therapy response by MRS and quantitative gene expression profiling in the choline pathway

21 January 2018

1 reference

Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers

21 January 2018

1 reference

Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression

21 January 2018

1 reference

Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.

21 January 2018

1 reference

Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K

21 January 2018

1 reference

Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells

21 January 2018

1 reference

Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation.

21 January 2018

1 reference

Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy

21 January 2018

1 reference

Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study.

21 January 2018

1 reference

A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomas

21 January 2018

1 reference

Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway

21 January 2018

1 reference

Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer

21 January 2018

1 reference

Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha

21 January 2018

1 reference

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

21 January 2018

1 reference

Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin

21 January 2018

1 reference

Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling

21 January 2018

1 reference

Molecular causes of the aberrant choline phospholipid metabolism in breast cancer

21 January 2018

1 reference

Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C.

21 January 2018

1 reference

Phosphatidylcholine breakdown and signal transduction

21 January 2018

1 reference

Phosphatidylcholine-specific phospholipase inhibitor D609 differentially affects MAP kinases and immediate-early genes in PC12 cells

21 January 2018

1 reference

Involvement of phosphatidylcholine-selective phospholipase C in activation of mitogen-activated protein kinase pathways in imidazoline receptor antisera-selected protein

21 January 2018

1 reference

Cellular localization and functional role of phosphatidylcholine-specific phospholipase C in NK cells

21 January 2018

1 reference

Adaptive functional differentiation of dendritic cells: integrating the network of extra- and intracellular signals

21 January 2018

1 reference

Contrasting effects of phosphatidylinositol- and phosphatidylcholine-specific phospholipase C on apoptosis in cultured endothelial cells.

21 January 2018

1 reference

Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells

21 January 2018

1 reference

Modulations of glycerophosphorylcholine and phosphorylcholine in Friend erythroleukemia cells upon in vitro-induced erythroid differentiation: a 31P NMR study.

21 January 2018

1 reference

Metabolic changes in undifferentiated and differentiated human colon adenocarcinoma cells studied by multinuclear magnetic resonance spectroscopy.

21 January 2018

1 reference

Increases in NMR-visible lipid and glycerophosphocholine during phenylbutyrate-induced apoptosis in human prostate cancer cells.

21 January 2018

1 reference

Inhibitors of histone deacetylase as new anticancer agents

21 January 2018

1 reference

Lovastatin enhances phenylbutyrate-induced MR-visible glycerophosphocholine but not apoptosis in DU145 prostate cells

21 January 2018

1 reference

Pluripotent stem cell lines

21 January 2018

1 reference

Stem cell profiling by nuclear magnetic resonance spectroscopy.

21 January 2018

1 reference

Nuclear magnetic resonance detects phosphoinositide 3-kinase/Akt-independent traits common to pluripotent murine embryonic stem cells and their malignant counterparts

21 January 2018

1 reference

Therapeutic potential of phosphoinositide 3-kinase inhibitors.

21 January 2018

1 reference

Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling.

21 January 2018

1 reference

Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells

21 January 2018

1 reference

Suppressing phosphatidylcholine-specific phospholipase C and elevating ROS level, NADPH oxidase activity and Rb level induced neuronal differentiation in mesenchymal stem cells.

21 January 2018

1 reference

Effect of oncogene transformation of rat embryo cells on cellular oxygen consumption and glycolysis.

21 January 2018

1 reference

Early estrogen-induced metabolic changes and their inhibition by actinomycin D and cycloheximide in human breast cancer cells: 31P and 13C NMR studies

21 January 2018

1 reference

Real-time measurements of cellular oxygen consumption, pH, and energy metabolism using nuclear magnetic resonance spectroscopy

21 January 2018

1 reference

Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).

21 January 2018

1 reference

Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model

21 January 2018

1 reference

Dynamics of prostate cancer cell invasion studied in vitro by NMR microscopy

21 January 2018

1 reference

Imaging prostate cancer invasion with multi-nuclear magnetic resonance methods: the Metabolic Boyden Chamber

21 January 2018

1 reference

Prostaglandins, their inhibitors and cancer

21 January 2018

1 reference

Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells

21 January 2018

1 reference

The effect of surgical wounding on tumour development

21 January 2018

1 reference

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

21 January 2018

1 reference

Phospholipid profiles of invasive human breast cancer cells are altered towards a less invasive phospholipid profile by the anti-inflammatory agent indomethacin

21 January 2018

1 reference

Exposure of human breast cancer cells to the anti-inflammatory agent indomethacin alters choline phospholipid metabolites and Nm23 expression

21 January 2018

1 reference

Real-time changes in 1H and 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin.

21 January 2018

1 reference

Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells

21 January 2018

1 reference

Choline phospholipid metabolites of human vascular endothelial cells altered by cyclooxygenase inhibition, growth factor depletion, and paracrine factors secreted by cancer cells

21 January 2018

1 reference

Predictors of response to interferon therapy

21 January 2018

1 reference

TNF-induced modulations of phospholipid metabolism in human breast cancer cells

21 January 2018

1 reference

Hypoxia in cancer cell metabolism and pH regulation

21 January 2018

1 reference

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

21 January 2018

1 reference

Proton pump inhibitors may reduce tumour resistance

21 January 2018

1 reference

Targeting vacuolar H+-ATPases as a new strategy against cancer

21 January 2018

1 reference

Drug resistance and the solid tumor microenvironment

21 January 2018

1 reference

Causes and consequences of increased glucose metabolism of cancers

21 January 2018

1 reference

The role of acidity in solid tumour growth and invasion

21 January 2018

1 reference

Enhancement of chemotherapy by manipulation of tumour pH.

21 January 2018

1 reference

Increased tumour extracellular pH induced by Bafilomycin A1 inhibits tumour growth and mitosis in vivo and alters 5-fluorouracil pharmacokinetics

21 January 2018

1 reference

Influence of pH on the uptake of 5-fluorouracil into isolated tumour cells

21 January 2018

1 reference

Causes and consequences of tumour acidity and implications for treatment

21 January 2018

1 reference

Role of pH in tumor-trapping of the anticancer drug 5-fluorouracil

21 January 2018

1 reference

Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours

21 January 2018

1 reference

V-ATPase inhibitors and implication in cancer treatment.

21 January 2018

1 reference

Bicarbonate increases tumor pH and inhibits spontaneous metastases

21 January 2018

1 reference

Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs

21 January 2018

1 reference

Biofunctionalized, phosphonate-grafted, ultrasmall iron oxide nanoparticles for combined targeted cancer therapy and multimodal imaging

21 January 2018

1 reference

Pharmacodynamic biomarkers for molecular cancer therapeutics

21 January 2018

1 reference

Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies

21 January 2018

1 reference

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

21 January 2018

1 reference

Pathological roles of MAPK signaling pathways in human diseases

21 January 2018

1 reference

Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells

21 January 2018

1 reference

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

Use of radiolabelled choline as a pharmacodynamic marker for the signal transduction inhibitor geldanamycin

21 January 2018

1 reference

c-Ha-ras oncogene expression increases choline uptake, CTP: phosphocholine cytidylyltransferase activity and phosphatidylcholine biosynthesis in the immortalized human keratinocyte cell line HaCaT.

21 January 2018

1 reference

Oncogenic Ha-Ras transformation modulates the transcription of the CTP:phosphocholine cytidylyltransferase alpha gene via p42/44MAPK and transcription factor Sp3.

21 January 2018

1 reference

Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction

21 January 2018

1 reference

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

Drug discovery approaches targeting the PI3K/Akt pathway in cancer

21 January 2018

1 reference

Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells

21 January 2018

1 reference

Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy

21 January 2018

1 reference

Phospholipase C-gamma1 in tumor progression.

21 January 2018

1 reference

Changes in choline metabolism as potential biomarkers of phospholipase C{gamma}1 inhibition in human prostate cancer cells.

21 January 2018

1 reference

Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion

21 January 2018

1 reference

Fatty acid synthase, a proficient multifunctional enzyme

21 January 2018

1 reference

Fatty acid synthase and cancer: new application of an old pathway

21 January 2018

1 reference

Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?

21 January 2018

1 reference

Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

21 January 2018

1 reference

Fatty acid synthase inhibition results in a magnetic resonance-detectable drop in phosphocholine

21 January 2018

1 reference

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

21 January 2018

1 reference

Heat shock protein 90: the cancer chaperone

21 January 2018

1 reference

Heat shock protein 90 as a drug target: some like it hot.

21 January 2018

1 reference

HSP90 inhibitors: multi-targeted antitumor effects and novel combinatorial therapeutic approaches in cancer therapy

21 January 2018

1 reference

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

1 reference

Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models

21 January 2018

1 reference

Histone acetylation and transcriptional regulatory mechanisms

21 January 2018

1 reference

Histone acetyltransferases

21 January 2018

1 reference

Histone deacetylases and cancer: causes and therapies

21 January 2018

1 reference

Histone deacetylase inhibitors in cancer therapy

21 January 2018

1 reference

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts

21 January 2018

1 reference

Important therapeutic targets in chronic myelogenous leukemia

21 January 2018

1 reference

Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells

21 January 2018

1 reference

Detection of resistance to imatinib by metabolic profiling: clinical and drug development implications

21 January 2018

1 reference

Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells.

21 January 2018

1 reference

Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading

21 January 2018

1 reference

RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation

21 January 2018

1 reference

Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells

21 January 2018

1 reference

Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft

21 January 2018

1 reference

Choline kinase alpha depletion selectively kills tumoral cells.

21 January 2018

1 reference

Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells.

21 January 2018

1 reference

Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action.

21 January 2018

1 reference

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models

21 January 2018

1 reference

Modulation of choline kinase activity in human cancer cells observed by dynamic 31P NMR.

21 January 2018

1 reference

The many faces of H89: a review

21 January 2018

1 reference

Positron emission tomography as an imaging biomarker

21 January 2018

1 reference

PET/CT for the staging and follow-up of patients with malignancies

21 January 2018

1 reference

Radionuclide molecular imaging using Affibody molecules

21 January 2018

1 reference

A robust coregistration method for in vivo studies using a first generation simultaneous PET/MR scanner

21 January 2018

1 reference

Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI.

21 January 2018

1 reference

Intrinsic susceptibility MR imaging of chemically induced rat mammary tumors: relationship to histologic assessment of hypoxia and fibrosis

21 January 2018

1 reference

A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy

21 January 2018

1 reference

Molecular imaging of hypoxia with radiolabelled agents

21 January 2018

1 reference

Radionuclide imaging of perfusion and hypoxia

21 January 2018

1 reference

Applications of magnetic resonance in model systems: tumor biology and physiology

21 January 2018

1 reference

pH imaging. A review of pH measurement methods and applications in cancers.

21 January 2018

1 reference

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

21 January 2018

1 reference

In vivo measurement of brain tumor pH using [11C]DMO and positron emission tomography

21 January 2018

1 reference

Activation of P-glycoprotein (Pgp)-mediated drug efflux by extracellular acidosis: in vivo imaging with 68Ga-labelled PET tracer

21 January 2018

1 reference

Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

21 January 2018

1 reference

A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment

21 January 2018

1 reference

Abnormal Choline Phospholipid Metabolism in Breast and Ovary Cancer:Molecular Bases for Noninvasive Imaging Approaches

21 January 2018

1 reference

Contribution of the PI3K/Akt/PKB signal pathway to maintenance of self-renewal in human embryonic stem cells

21 January 2018

1 reference

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/NBM.1658

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21387442%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference