(Q37855818)

24 August 2017

1 reference

title

Leveraging therapeutic potential of multi-targeted siRNA inhibitors (English)

1 reference

24 August 2017

Qing Ge

1

1 reference

24 August 2017

John J Xu

2

1 reference

24 August 2017

David M Evans

3

1 reference

24 August 2017

A James Mixson

4

1 reference

24 August 2017

Harry Y Yang

5

1 reference

24 August 2017

Patrick Y Lu

6

1 reference

24 August 2017

publication date

1 December 2009

1 reference

Future Medicinal Chemistry

24 August 2017

published in

1 reference

24 August 2017

volume

1

1 reference

24 August 2017

issue

9

1 reference

24 August 2017

page(s)

1671-1681

1 reference

Early initiation of antiretroviral therapy results in decreased morbidity and mortality among patients with TB and HIV.

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Stringent testing identifies highly potent and escape-proof anti-HIV short hairpin RNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Dual targeting of EphA2 and FAK in ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

RNAi: the nuts and bolts of the RISC machine

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

A three-dimensional view of the molecular machinery of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

RNA interference is mediated by 21- and 22-nucleotide RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

The RNA-induced silencing complex is a Mg2+-dependent endonuclease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Functional siRNAs and miRNAs Exhibit Strand Bias

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

On the road to reading the RNA-interference code

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

ATP requirements and small interfering RNA structure in the RNA interference pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Argonaute2, a link between genetic and biochemical analyses of RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Utilizing RNA interference to enhance cancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Rational siRNA design for RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Overcoming the innate immune response to small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Comparative assessment of siRNA and shRNA off target effects: what is slowing clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

RNAi in human cells: basic structural and functional features of small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Genetic therapies against HIV.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

RNAi for treating hepatitis B viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Nucleotide sequence and mutation rate of the H strain of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Mutation rates among RNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Genetic diversity of the hepatitis C virus: impact and issues in the antiviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Short interfering RNA confers intracellular antiviral immunity in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Hepatitis C Virus Replicons Escape RNA Interference Induced by a Short Interfering RNA Directed against the NS5b Coding Region

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

siRNA-resistance in treated HCV replicon cells is correlated with the development of specific HCV mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Human immunodeficiency virus type 1 escape from RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Silencing of HIV-1 with RNA interference: a multiple shRNA approach

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Sequence homology required by human immunodeficiency virus type 1 to escape from short interfering RNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Novel Pol II fusion promoter directs human immunodeficiency virus type 1-inducible coexpression of a short hairpin RNA and protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

HIV evades RNA interference directed at TAR by an indirect compensatory mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

RNA interference of HIV replication

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

RNAi-mediated knockdown of target genes: a promising strategy for pancreatic cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

RNA interference and cancer: endogenous pathways and therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Harnessing the RNA interference pathway to advance treatment and prevention of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Modulation of angiogenesis with siRNA inhibitors for novel therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Inhibitors of vascular endothelial growth factor in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Antiangiogenic therapy in brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Integrin-mediated regulation of neurovascular development, physiology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

siRNA vs. shRNA: similarities and differences

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

RNAi-mediated downregulation of urokinase plasminogen activator receptor and matrix metalloprotease-9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Specific interference of urokinase-type plasminogen activator receptor and matrix metalloproteinase-9 gene expression induced by double-stranded RNA results in decreased invasion, tumor growth, and angiogenesis in gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Dual knockdown of N-ras and epiregulin synergistically suppressed the growth of human hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.131

21 January 2018

Identifiers

DOI

10.4155/FMC.09.131

1 reference

24 August 2017

1 reference