(Q37855933)

24 August 2017

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title

The AMPA receptor as a therapeutic target: current perspectives and emerging possibilities (English)

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24 August 2017

Ian R Mellor

1

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PubMed ID

21426207

24 August 2017

language of work or name

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1 May 2010

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Future Medicinal Chemistry

24 August 2017

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24 August 2017

2

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24 August 2017

5

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24 August 2017

877-891

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Presynaptic glutamate receptors: physiological functions and mechanisms of action.

24 August 2017

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A nomenclature for ligand-gated ion channels

21 January 2018

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The structure and function of glutamate receptor ion channels

21 January 2018

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Glutamate receptor ion channels

21 January 2018

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The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

21 January 2018

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Structural aspects of AMPA receptor activation, desensitization and deactivation

21 January 2018

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X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

21 January 2018

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A molecular determinant for submillisecond desensitization in glutamate receptors

21 January 2018

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Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

21 January 2018

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Selective upregulation of the flip-flop splice variants of AMPA receptor subunits in the rat spinal cord after hindpaw inflammation

21 January 2018

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The cell biology of synaptic plasticity: AMPA receptor trafficking

21 January 2018

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AMPA receptor trafficking and synaptic plasticity

21 January 2018

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Control of kinetic properties of AMPA receptor channels by nuclear RNA editing

21 January 2018

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RNA editing (R/G site) and flip-flop splicing of the AMPA receptor subunit GluR2 in nervous tissue of epilepsy patients

21 January 2018

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Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death

21 January 2018

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Modeling of the pore domain of the GLUR1 channel: homology with K+ channel and binding of channel blockers.

21 January 2018

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Intracellular polyamines mediate inward rectification of Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

21 January 2018

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Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block

21 January 2018

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Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors

21 January 2018

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Competitive AMPA receptor antagonists

21 January 2018

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Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat.

21 January 2018

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The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study

21 January 2018

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2,3-benzodiazepine-type AMPA receptor antagonists and their neuroprotective effects.

21 January 2018

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Molecular mechanism of AMPA receptor noncompetitive antagonism

21 January 2018

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Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

21 January 2018

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Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655.

21 January 2018

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Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466

21 January 2018

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Combined strategies for the discovery of ionotropic glutamate receptor antagonists

21 January 2018

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Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist

21 January 2018

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CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo

21 January 2018

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Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors

21 January 2018

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AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins

21 January 2018

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Polyamine toxins: development of selective ligands for ionotropic receptors.

21 January 2018

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Natural products as tools for studies of ligand-gated ion channels

21 January 2018

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Common binding site for externally and internally applied AMPA receptor channel blockers

21 January 2018

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Targeting ionotropic receptors with polyamine-containing toxins

21 January 2018

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Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives

21 January 2018

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Design, synthesis, and pharmacological characterization of polyamine toxin derivatives: potent ligands for the pore-forming region of AMPA receptors.

21 January 2018

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Pathologically activated therapeutics for neuroprotection

21 January 2018

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Design of antagonists for NMDA and AMPA receptors

21 January 2018

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Selective blockade of Ca2+ permeable AMPA receptors in CA1 area of rat hippocampus.

21 January 2018

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Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives.

21 January 2018

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The open channel blocking drug, IEM-1460, reveals functionally distinct alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors in rat brain neurons

21 January 2018

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Studies of the roles of NMDA and AMPA glutamate receptors in the mechanism of corasole convulsions in mice.

21 January 2018

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Comparison of the anticonvulsive activities of organic mono- and dications with their abilities to inhibit NMDA and AMPA glutamate receptors.

21 January 2018

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Mechanism of positive allosteric modulators acting on AMPA receptors

21 January 2018

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Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro

21 January 2018

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Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats.

21 January 2018

1 reference

Role of the glutamatergic system in nicotine dependence : implications for the discovery and development of new pharmacological smoking cessation therapies

21 January 2018

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Edited GluR2, a gatekeeper for motor neurone survival?

21 January 2018

1 reference

Excitotoxicity and ALS: what is unique about the AMPA receptors expressed on spinal motor neurons?

21 January 2018

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Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMA.

21 January 2018

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Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis

21 January 2018

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Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

21 January 2018

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The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.

21 January 2018

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Modulation of AMPA receptors in spinal motor neurons by the neuroprotective agent riluzole.

21 January 2018

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AMPA receptor subunit GluR2 gates injurious signals in ischemic stroke

21 January 2018

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Perinatal ischemic stroke

21 January 2018

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Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)

21 January 2018

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21 January 2018

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Diagnosis and treatment of Parkinson disease: molecules to medicine

21 January 2018

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AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys

21 January 2018

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Effects of 2,3-benzodiazepine AMPA receptor antagonists on dopamine turnover in the striatum of rats with experimental parkinsonism.

21 January 2018

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Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis

21 January 2018

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Excitatory amino acids and multiple sclerosis: evidence from cerebrospinal fluid

21 January 2018

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Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.

21 January 2018

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Increased expression and function of glutamate transporters in multiple sclerosis

21 January 2018

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GluR2-free alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors intensify demyelination in experimental autoimmune encephalomyelitis

21 January 2018

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Concentrations of glutamate released following spinal cord injury kill oligodendrocytes in the spinal cord

21 January 2018

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Amelioration of functional deficits from spinal cord trauma with systemically administered NBQX, an antagonist of non-N-methyl-D-aspartate receptors

21 January 2018

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Glutamate receptor subunit expression after spinal cord injury in young rats

21 January 2018

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Ventral root avulsion leads to downregulation of GluR2 subunit in spinal motoneurons in adult rats

21 January 2018

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Cell death after spinal cord injury is exacerbated by rapid TNF alpha-induced trafficking of GluR2-lacking AMPARs to the plasma membrane

21 January 2018

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Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors.

21 January 2018

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Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush

21 January 2018

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Moving towards therapies for juvenile Batten disease?

21 January 2018

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High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease

21 January 2018

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An autoantibody inhibitory to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease

21 January 2018

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Selectively increased sensitivity of cerebellar granule cells to AMPA receptor-mediated excitotoxicity in a mouse model of Batten disease

21 January 2018

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Attenuation of AMPA receptor activity improves motor skills in a mouse model of juvenile Batten disease

21 January 2018

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Prolonged effect of an anesthetic dose of ketamine on behavioral despair

21 January 2018

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A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

21 January 2018

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Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors.

21 January 2018

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Emerging role of glutamate in the pathophysiology of major depressive disorder.

21 January 2018

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AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression.

21 January 2018

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A role for AMPA receptors in mood disorders

21 January 2018

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Novel drugs and therapeutic targets for severe mood disorders

21 January 2018

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AMPA receptor potentiators: application for depression and Parkinson's disease

21 January 2018

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Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

21 January 2018

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Antidepressant-like actions of an AMPA receptor potentiator (LY392098).

21 January 2018

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21 January 2018

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Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice

21 January 2018

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Testing the glutamate hypothesis of schizophrenia

21 January 2018

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Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviors

21 January 2018

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Microglial activation in schizophrenia and minocycline treatment.

21 January 2018

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Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline

21 January 2018

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Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations.

21 January 2018

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Glutamate receptors and pain

21 January 2018

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Protein kinases regulate the phosphorylation of the GluR1 subunit of AMPA receptors of spinal cord in rats following noxious stimulation

21 January 2018

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The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain

21 January 2018

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Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

21 January 2018

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Intracellular spermine confers rectification on rat calcium-permeable AMPA and kainate receptors

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.10.27

1 reference

24 August 2017

1 reference

PubMed ID

21426207