(Q37856373)

24 August 2017

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title

The tuberous sclerosis complex: balancing proliferation and survival (English)

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24 August 2017

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Romana Tomasoni

1

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Anna Mondino

object named as

Anna Mondino

series ordinal

2

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publication date

1 April 2011

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Biochemical Society Transactions

24 August 2017

published in

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24 August 2017

volume

39

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24 August 2017

issue

2

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24 August 2017

page(s)

466-471

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The tuberous sclerosis complex

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Rheb binds and regulates the mTOR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

The tuberin-hamartin complex negatively regulates beta-catenin signaling activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Retention of membrane-localized beta-catenin in cells lacking functional polycystin-1 and tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Convergence of Wnt, beta-catenin, and cadherin pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Neuropathology of tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Tuberous Sclerosis Complex 1 Regulates dE2F1 Expression during Development and Cooperates with RBF1 to Control Proliferation and Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Aberrant beta-catenin signaling in tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

E2F - at the crossroads of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

FOXO-regulated transcription restricts overgrowth of Tsc mutant organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390466

21 January 2018

Identifiers

DOI

10.1042/BST0390466

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24 August 2017

1 reference